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Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy

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Abstract

Photothermal therapy (PTT) may lead to healthy tissue damage, tumor metastasis, and recurrence, which makes mild photothermal therapy (mild PTT) stand out. However, overcoming heat resistance, insufficient therapeutic effect, and poor photothermal conversion efficiency has become new challenge. Herein, we report a dynamic supramolecular nanocarrier formed from amide-sericin and aldehyde-polyhydroxy glucan (denoted as SDA), the loose cavity of which can be filled by using the pharmaceutical combination of lonidamine (LND) and NIR-II photothermal agent of IR-1061, producing SDLI with a tighter inner hole, smaller and uniform particle size and excellent stability due to multiple pulling forces. Moreover, the intricate internal network structure prevents the hydrophobic IR-1061 from forming aggregates in the small cavity, and the photothermal conversion efficiency (PCE) can reach 48.9%. At the acidic tumor microenvironment of pH 6.5, the controlled release of LND can solve the problem of heat resistance of NIR-II mild PTT and significantly improve the therapeutic effect of NIR-II mild PTT. Meanwhile, SDLI also shows a reasonable tumor inhibition rate, so the synergistic strategy of inhibiting tumor energy metabolism and NIR-II mild PTT to magnify mitochondrial oxidative stress, continuous cell stress state-induced immunogenic cell death to promote the induction of tumor apoptosis is proposed to achieve more effective cancer treatment.

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 22375168), Chongqing Talents of Exceptional Young Talents Project, China (Nos. CQYC202005029 and cstc2021ycjh-bgzxm0061), Shuangcheng cooperative agreement research grant of Yibin, China (No. XNDX2022020013) and the Innovation Platform for Academicians of Hainan Province.

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  1. Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, School of Materials and Energy & Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing, 400715, China

    Hongmei Liu, Jiming Xu, Mengjie Ye, Hengbo Zhang, Linlin Han, Jingting Wang, Peng Xue, Yuejun Kang & Zhigang Xu

  2. Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, China

    Zhigang Xu

  3. Yibin Academy of Southwest University, Yibin, 644000, China

    Peng Xue, Yuejun Kang & Zhigang Xu

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  1. Hongmei Liu
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Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy

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Liu, H., Xu, J., Ye, M. et al. Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy. Nano Res. 17, 4314–4328 (2024). https://doi.org/10.1007/s12274-023-6296-4

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