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Ferric iron coordinated cisplatin prodrug reprograms the immune-cold tumor microenvironment through tumor hypoxia relief for enhanced cancer photodynamic-immunotherapy

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Abstract

The microenvironment of hypoxia and immune-cold limits the therapeutic outcomes of immune checkpoint blockade (ICB) therapy in solid tumors. It is important and imperative to search new strategies to relieve tumor hypoxia and reverse immunosuppression of cold tumors. In this study, the oxygen (O2) self-replenishing nano-enabled coordination platform can be used to induce potent antitumor immune response in cold tumors. The nanoplatform can produce O2 by catalyzing hydrogen peroxide (H2O2) in tumor site effectively, showing excellent photodynamic therapy (PDT) performance. Meanwhile, it can further trigger immunogenic cell death (ICD), enhance T cell infiltration, reverse immunosuppression, and reprogram the immune-cold tumor microenvironment. In vitro and in vivo results demonstrate that the nanoplatform has potential for eradicating tumors and long-term immunological memory effect. The nanoplatform opens up a strategy for reprograming the immunosuppressive microenvironment in cold tumors.

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Acknowledgements

This work is supported by the National Natural Science Foundation of China (Nos. 52103164, and 52173142), Guangdong Basic and Applied Basic Research Foundation (Nos. 2021A1515220033 and 2020A1515111059), and the Fundamental Research Funds for the Central Universities (No. JUSRP123079).

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  1. Yinchu Ma and Yingli Luo contributed equally to this work.

Authors and Affiliations

  1. Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China

    Yinchu Ma & Yingli Luo

  2. Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China

    Yinchu Ma

  3. School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China

    Xinfeng Tang & Wei Jiang

  4. Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China

    Hongjun Li

  5. Joint Centre of Translational Medicine, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China

    Jilong Wang

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  1. Yinchu Ma
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Correspondence to Yinchu Ma, Hongjun Li or Jilong Wang.

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Ferric iron coordinated cisplatin prodrug reprograms the immune-cold tumor microenvironment through tumor hypoxia relief for enhanced cancer photodynamic-immunotherapy

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Ma, Y., Luo, Y., Tang, X. et al. Ferric iron coordinated cisplatin prodrug reprograms the immune-cold tumor microenvironment through tumor hypoxia relief for enhanced cancer photodynamic-immunotherapy. Nano Res. 16, 9930–9939 (2023). https://doi.org/10.1007/s12274-023-5919-0

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