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A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity

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Abstract

As a revolutionary cancer treatment strategy, immunotherapy has attracted great attention. However, the effect of immunotherapy such as immune checkpoint blockade (ICB) is usually limited by insufficient immune response in the body. Herein, a polycation-based magnetic nanocluster platform was developed to load therapeutic nucleic acids, which could achieve gene therapy-mediated ICB and efficient magnetic hyperthermia therapy (MHT). The silencing of immune checkpoints together with MHT-induced immunogenic cell death (ICD) effectively alleviated the immune escape of cancer cells and significantly enhanced the visibility of cancer cells to the immune system. This combined treatment strategy activated a strong adaptive anticancer immune response in vivo, greatly inhibiting tumor growth, metastasis and recurrence.

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Acknowledgements

The authors are thankful to National Natural Science Foundation of China (Nos. 51925305, 51873208, 51833010, and 52203183), the National Key Research and Development Program of China (No. 2021YFB3800900), and the talent cultivation project Funds for the Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (No. HRTP-[2022]52).

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Authors and Affiliations

  1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Zhiyu Yang, Xiaoya Guo, Meng Meng, Tong Li, Zhaohui Tang, Huayu Tian & Xuesi Chen

  2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China

    Zhiyu Yang, Xiaoya Guo, Meng Meng, Tong Li, Zhaohui Tang, Huayu Tian & Xuesi Chen

  3. State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China

    Huapan Fang & Huayu Tian

  4. Jilin Biomedical Polymers Engineering Laboratory, Changchun, 130022, China

    Zhiyu Yang, Xiaoya Guo, Meng Meng, Tong Li, Zhaohui Tang, Huayu Tian & Xuesi Chen

  5. Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), Xiamen, 361005, China

    Huapan Fang & Huayu Tian

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  1. Zhiyu Yang
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  2. Xiaoya Guo
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  3. Meng Meng
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  4. Tong Li
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  5. Huapan Fang
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  6. Zhaohui Tang
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  7. Huayu Tian
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  8. Xuesi Chen
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Correspondence to Huapan Fang or Huayu Tian.

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A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity

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Yang, Z., Guo, X., Meng, M. et al. A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity. Nano Res. 16, 11206–11215 (2023). https://doi.org/10.1007/s12274-023-5839-z

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  • DOI: https://doi.org/10.1007/s12274-023-5839-z

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