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Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose

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Abstract

Conventional glassy carbon electrodes (GCE) cannot meet the requirements of future electrodes for wider use due to low conductivity, high cost, non-portability, and lack of flexibility. Therefore, cost-effective and wearable electrode enabling rapid and versatile molecule detection is becoming important, especially with the ever-increasing demand for health monitoring and point-of-care diagnosis. Graphene is considered as an ideal electrode due to its excellent physicochemical properties. Here, we prepare graphene film with ultra-high conductivity and customize the 3-electrode system via a facile and highly controllable laser engraving approach. Benefiting from the ultra-high conductivity (5.65 × 105 Sm−1), the 3-electrode system can be used as multifunctional electrode for direct detection of dopamine (DA) and enzyme-based detection of glucose without further metal deposition. The dynamic ranges from 1–200 µM to 0.5–8.0 mM were observed for DA and glucose, respectively, with a limit of detection (LOD) of 0.6 µM and 0.41 mM. Overall, the excellent target detection capability caused by the ultra-high conductivity and ease modification of graphene films, together with their superb mechanical properties and ease of mass-produced, provides clear potential not only for replacing GCE for various electrochemical studies but also for the development of portable and highperformance electrochemical wearable medical devices.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51672204 and 22102128), the Fundamental Research Funds for the Central Universities (WUT: 2021IVA66, WUT: 2022IVA172, and WUT: 2020IB005), and the Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City (No. 520LH054).

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Authors and Affiliations

  1. State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan, 430070, China

    Xiaodong Ji, Zixin Zhang, Yunfa Si, Huaqiang Fu, Zibo Chen & Daping He

  2. Hubei Engineering Research Center of RF-Microwave Technology and Application, Wuhan University of Technology, Wuhan, 430070, China

    Xin Zhao, Wei Qian & Daping He

  3. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China

    Zhe Wang

  4. School of Information Engineering, Wuhan University of Technology, Wuhan, 430070, China

    Huihui Jin

  5. School of Water, Energy and Environment, Cranfield University, Milton Keynes, MK43 0AL, UK

    Zhugen Yang

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  1. Xiaodong Ji
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  2. Xin Zhao
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  3. Zixin Zhang
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  4. Yunfa Si
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  8. Zhe Wang
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  10. Zhugen Yang
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  11. Daping He
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Correspondence to Xin Zhao, Huihui Jin or Daping He.

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Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose

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Ji, X., Zhao, X., Zhang, Z. et al. Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose. Nano Res. 16, 6361–6368 (2023). https://doi.org/10.1007/s12274-023-5459-7

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  • DOI: https://doi.org/10.1007/s12274-023-5459-7

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