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Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging

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Abstract

Optical imaging possesses important implications for early disease diagnosis, timely disease treatment, and basic medical as well as biological research. Compared with the traditionary near-infrared (NIR-I) window (650–950 nm) optical imaging, the emerging second near-infrared (NIR-II) window optical imaging technology owns the great superiorities of non-invasiveness, nonionizing radiation, and real-time dynamic imaging with the low biological interference, can significantly improve the tissue penetration depth and detection sensitivity, thus expecting to achieve accurate and precise diagnosis of major diseases. Inspired by the conspicuous superiorities, an increasing number of versatile NIR-II fluorophores have been legitimately designed and engineered for precisely deep-tissue mapping-mediated theranostics of life-threatening diseases. Organic semiconducting nanomaterials (OSNs) are derived from organic conjugated molecules with π-electron delocalized skeletons, which show greatly preponderant prospects in the biomedicine field due to the excellent photoelectric property, tunable energy bands, and fine biocompatibility. In this review, the superiorities of NIR-II fluorescence imaging using OSNs for brilliant visualization various of diseases, including tongue cancer, ovarian cancer, osteosarcoma, bacteria or pathogens infection, kidney dysfunction, rheumatoid arthritis, liver injury, and cerebrovascular function, are emphatically summarized. Finally, the reasonable prospects and persistent efforts for repurposing OSNs to facilitate the clinical translation of NIR-II fluorescence phototheranostics are outlined.

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Acknowledgements

This work was supported by the Natural Science Foundation of Jiangxi Province (Nos. 20212BAB214005 and 20212ACB214002) and the Research startup fund of East China Jiaotong University (No. 465).

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  1. Strait Laboratory of Flexible Electronics (SLoFE), Strait Institute of Flexible Electronics (SIFE, Future Technologies), Fujian Normal University, Fuzhou, 350117, China

    Xiaoming Hu, Fengwei Sun, Zhen Yang & Wei Huang

  2. Jiangxi Key Laboratory of Nanobiomaterials, School of Materials Science and Engineering, East China Jiaotong University, Nanchang, 330013, China

    Xiaoming Hu & Caijun Zhu

  3. Frontiers Science Center for Flexible Electronics (FSCFE), MIIT Key Laboratory of Flexible Electronics (KLoFE), Northwestern Polytechnical University, Xi’an, 710072, China

    Wei Huang

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  2. Fengwei Sun
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  4. Zhen Yang
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Correspondence to Zhen Yang or Wei Huang.

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Hu, X., Sun, F., Zhu, C. et al. Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging. Nano Res. 16, 5140–5154 (2023). https://doi.org/10.1007/s12274-022-5145-1

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