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Manganese-doped mesoporous polydopamine nanoagent for T1–T2 magnetic resonance imaging and tumor therapy

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Abstract

Theranostic nanodrugs combining magnetic resonance imaging (MRI) and cancer therapy have attracted extensive interest in cancer diagnosis and treatment. Herein, a manganese (Mn)-doped mesoporous polydopamine (Mn-MPDA) nanodrug incorporating the nitric oxide (NO) prodrug BNN6 and immune agonist R848 was developed. The nanodrug responded to the H+ and glutathione being enriched in tumor microenvironment to release R848 and Mn2+. The abundant Mn2+ produced through a Fenton-like reaction enabled a highly sensitive T1–T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug, based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy. Meanwhile, R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype. Consequently, a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer, which manifested the great promise of this multifunctional nanoplatform in cancer treatment.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 51933011 and 31971296), the Key Areas Research and Development Program of Guangzhou (No. 202007020006), Guangdong Basic and Applied Basic Research Foundation (No. 2020A1515010523), Guangzhou Science and Technology Bureau (No. 202102010181), and Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument (Sun Yat-sen University, No. 2020B1212060077).

The animal study protocol was approved by the Institutional Animal Care and Use Committee at Sun Yat-sen University (SYSU-IACUC-2021-000225).

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Author notes

  1. Xiuqi Hou, Xi Yang, and Yanwen Xu contributed equally to this work.

Authors and Affiliations

  1. School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, 510006, China

    Xiuqi Hou, Xi Yang, Jiayin Lin, Sitong Liu, Jie Liu & Zhong Cao

  2. Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China

    Fang Zhang, Xiaohui Duan & Jun Shen

  3. Translational Medicine Institute, Shenzhen Second People’s Hospital, the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China

    Yanwen Xu

  4. Nanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China

    Xintao Shuai

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  1. Xiuqi Hou
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Correspondence to Xintao Shuai or Zhong Cao.

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Hou, X., Yang, X., Xu, Y. et al. Manganese-doped mesoporous polydopamine nanoagent for T1–T2 magnetic resonance imaging and tumor therapy. Nano Res. 16, 2991–3003 (2023). https://doi.org/10.1007/s12274-022-4877-4

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  • DOI: https://doi.org/10.1007/s12274-022-4877-4

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