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NIR-II fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis

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Abstract

Ovarian cancer is a global problem, and is typically diagnosed in the middle or late stages, with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic methods. Dual-modal near-infrared II (NIR-II, 1,000–1,700 nm) fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep penetration. Herein, we report a novel organic NIR-II dye (H10) with excellent aggregation-induced-emission (AIE) characteristics (I/I0 > 1.6) utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole (ST)-based building block. Then, water-soluble and biocompatible H10@follicle-stimulating hormone (H10@FSH) dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were synthesized. Finally, for the first time, in vivo dual-mode NIR-II fluorescent/photoacoustic (PA) imaging and image-guided surgery of patient-derived tumor xenograft (PDTX) and micro-metastatic abdominal ovarian cancer lesions were investigated. This novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients.

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Acknowledgements

The work was supported by the National Key Research and development Program of China (Nos. 2020YFA0908800 and 2015DFA30440), the National Natural Science Foundation of China (Nos. 82111530209, 81773674, 81573383, 91959103, and 61971447), Hubei Province Scientific and Technical Innovation Key Project (No. 2020BAB058), Beijing Natural Science Foundation (No. JQ18023), Shenzhen Science and Technology Research Grant (No. JCYJ20190808152019182), the Local Development Funds of Science and Technology Department of Tibet (Nos. XZ202102YD0033C and XZ202202YD0021C), and the Fundamental Research Funds for the Central Universities. We would like to thank Prof. Dr. Xiaoquan Yang and Miss Ximiao Yu (Huazhong University of Science and Technology) for their generous help in providing a home-made PA microscope setup in this research.

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  1. Siyu Lu, Liru Xue, and Meng Yang contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Virology, Department Gynecology, Cancer Biology Research Center, Tongji Hospital; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Siyu Lu, Liru Xue, Xuechuan Hong & Mingfu Wu

  2. Department of Cardiology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China

    Siyu Lu, Jingjing Wang, Yang Li, Xuechuan Hong & Yuling Xiao

  3. Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China

    Meng Yang & Yuxin Jiang

  4. College of Science, Research Center for Ecology, Laboratory of Extreme Environmental Biological Resources and Adaptive Evolution, Tibet University, Lhasa, 850000, China

    Xuechuan Hong

  5. Shenzhen Institute of Wuhan University, Shenzhen, 518057, China

    Yuling Xiao

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  1. Siyu Lu
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Correspondence to Mingfu Wu or Yuling Xiao.

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Lu, S., Xue, L., Yang, M. et al. NIR-II fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis. Nano Res. 15, 9183–9191 (2022). https://doi.org/10.1007/s12274-022-4592-z

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