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Metformin capped Cu2(OH)3Cl nanosheets for chemodynamic wound disinfection

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Abstract

Recently, the development of chemodynamic therapy (CDT) offers a potential approach for fighting bacteria and treating infectious diseases, in which those CDT nanoagents can catalyze the generation of hydroxyl radicals (•OH) to destroy bacteria. In this work, to improve the efficiency of CDT, we have designed a new kind of metformin (Met)-capped two-dimensional Cu2(OH)3Cl nanosheets (CuOHCl-Met NSs) with good monodispersity, highly positive charge, and good biocompatibility for improving antibacterial effect and accelerating wound healing. With the capped Met, CuOHCl-Met NSs can effectively kill bacteria under a low concentration (6 µg·mL−1) and a short treatment time (in 15 min), showing great advantages over the counterpart without Met. In vivo results demonstrated that CuOHCl-Met NSs accelerated the tissue regeneration of staphylococcus aureus-infected dermal wounds. This study provides a new pathway for improving efficiency of CDT nanoagent through using old drug.

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Acknowledgements

The work was supported by the National Natural Science Foundation of China (Nos. 82072065 and 81471784), and the National Youth Talent Support Program.

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  1. Xueyu Wang and Shaobo Wang contributed equally to this work.

Authors and Affiliations

  1. 306th Clinical College of PLA, The Fifth Clinical College, Anhui Medical University, Beijing, 100101, China

    Xueyu Wang, Teng Xu & Shu Yan

  2. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China

    Xueyu Wang, Shaobo Wang, Shuncheng Yao, Yunchao Zhao, Zeyu Zhang, Tian Huang & Linlin Li

  3. Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning, 530004, China

    Shaobo Wang, Yunchao Zhao, Zeyu Zhang, Tian Huang & Linlin Li

  4. PLA Strategic Support Force Characteristic Medical Center, Beijing, 100101, China

    Xueyu Wang, Jiao Gao, Teng Xu & Shu Yan

  5. School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China

    Shuncheng Yao & Linlin Li

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  1. Xueyu Wang
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  2. Shaobo Wang
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Wang, X., Wang, S., Gao, J. et al. Metformin capped Cu2(OH)3Cl nanosheets for chemodynamic wound disinfection. Nano Res. 16, 3991–3997 (2023). https://doi.org/10.1007/s12274-022-4457-5

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