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An implantable antibacterial drug-carrier: Mesoporous silica coatings with size-tunable vertical mesochannels

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Abstract

Implant-associated bacterial infection remains one of the most common and serious complications. Therefore, a surface boasting long-term antibacterial ability for implants is highly desirable. Herein, mesoporous silica coatings (MSCs) with vertical and size-tunable mesochannels are fabricated on a variety of metal substrates via a nano-interfacial oriented assembly approach. Such facile and versatile approach relies on the vertically oriented fusion of composite micelles on the nanoscale flatness surface of substrates. Such orientation assembly process endows the MSCs with vertical mesochannels, tunable mesopore size (ca. 5.5–13.5 nm), and switchable substrates even with complex and diversified surfaces. Importantly, the MSCs on titanium substrates (Ti@MSCs) exhibit excellent performances for drug adsorption and sustained release. The saturation adsorption capacity can reach 0.544 µg·cm−2 towards minocycline hydrochloride (MC-HCl) antibiotic molecules, which is 6.5 times as the bare titanium (Ti) substrate. In addition, the drug release time can be controlled from 84 to 216 h by simply adjusting the mesopore size. As a proof of concept, the Ti@MSCs can realize a higher antibacterial rate (95.9%), compared with the bare Ti (70.3%). The results highlight the high potential of MSCs as implant coating for long-term preventing and eliminating peri-implantitis.

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Acknowledgements

This work is supported by the National Key R&D Program of China (Nos. 2018YFE0201701 and 2018YFA0209401), and the National Natural Science Foundation of China (Nos. 22088101, 21733003, and 21975050), Science and Technology Commission of Shanghai Municipality (Nos. 18ZR1406300 and 19JC1410700).

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  1. Mengli Liu and Fang Huang contributed equally to this work.

Authors and Affiliations

  1. Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China

    Mengli Liu, Chin-Te Hung, Liwei Wang, Yupu Liu & Wei Li

  2. Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, 361015, China

    Fang Huang

  3. Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Wei Bi

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  1. Mengli Liu
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Correspondence to Wei Bi or Wei Li.

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Liu, M., Huang, F., Hung, CT. et al. An implantable antibacterial drug-carrier: Mesoporous silica coatings with size-tunable vertical mesochannels. Nano Res. 15, 4243–4250 (2022). https://doi.org/10.1007/s12274-021-4055-y

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