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Regulation of Glial Function by Noncoding RNA in Central Nervous System Disease

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Abstract

Non-coding RNAs (ncRNAs) are a class of functional RNAs that play critical roles in different diseases. NcRNAs include microRNAs, long ncRNAs, and circular RNAs. They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes of central nervous system (CNS) diseases. Mounting evidence indicates that ncRNAs play key roles in CNS diseases. Further elucidating the mechanisms of ncRNA underlying the process of regulating glial function that may lead to the identification of novel therapeutic targets for CNS diseases.

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Acknowledgements

This review was supported by grants from the Science and Technology innovation 2030–Major Project of the Ministry of Science and Technology of China (2021ZD0202904/2021ZD0202900), the National Science Fund Distinguished Young Scholars (82025033), the National Natural Science Foundation of China (82230115, 82273914, 81903591), ZhiShan Scholar Program of Southeast University (2242022R40059) and the Jiangsu Provincial Key Laboratory of Critical Care Medicine (JSKLCCM–2022–02–008).

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  1. Department of Pharmacology, Jiangsu Provincial Key Laboratory, School of Medicine, Southeast University, Nanjing, 210009, China

    Ying Bai, Hui Ren, Liang Bian, You Zhou, Xinping Wang, Zhongli Xiong, Ziqi Liu, Bing Han & Honghong Yao

  2. Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China

    Honghong Yao

  3. Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210009, China

    Honghong Yao

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  1. Ying Bai
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Bai, Y., Ren, H., Bian, L. et al. Regulation of Glial Function by Noncoding RNA in Central Nervous System Disease. Neurosci. Bull. 39, 440–452 (2023). https://doi.org/10.1007/s12264-022-00950-6

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