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Anaplastic Large Cell Lymphoma with Oral Manifestation: A Series of Four Cases and Literature Review

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Abstract

The aim of this study was to describe the clinicopathological and immunohistochemical features of four cases of anaplastic large cell lymphoma (ALCL) diagnosed through oral manifestations. Clinical data were collected from charts of a single oral pathology laboratory over a 5-year period (2014–2019) and all cases were evaluated by conventional hematoxylin and eosin staining and an extended immunohistochemical panel comprising CD45, CD20, CD3, CD4, CD7, CD30, CD99, CD138, cytokeratin AE1/AE3, EMA, ALK, MUM-1 and Ki-67. The study included 3 male (75%) and 1 female (25%) patients, with a median age of 44 years. The most common intraoral affected site was the alveolar ridge (50%). Clinically, all cases were characterized as an ulcerated bleeding mass. Microscopically, proliferation of anaplastic large lymphoid cells with medium to large-sized, abundant amphophilic to eosinophilic cytoplasm and eccentric nuclei were observed. All cases were positive for CD30, while two cases strongly express ALK. Two patients died of the disease. Careful correlation of clinical, morphological and immunohistochemical data are necessary to establish the diagnosis of oral manifestation of ALCL since its microscopical features may mimic other malignant tumors. Clinicians and pathologists should consider ALCL in the differential diagnosis when evaluating oral ulcerated swellings exhibiting large lymphoid cells in patients with lymphadenopathy.

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Authors and Affiliations

  1. Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho 373, Prédio Do CCS, Bloco K, 2° andar, Sala 56, Ilha da Cidade Universitária, Rio de Janeiro, RJ, 21.941-902, Brazil

    Bruno Augusto Benevenuto de Andrade, Maria Danielle Fontes, Michelle Agostini & Mário José Romañach

  2. Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas (FOP-UNICAMP), Piracicaba, Brazil

    Ana Luiza Oliveira Corrêa Roza & Pablo Agustin Vargas

  3. Department of Pathology, School of Medicine, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Nathalie Henriques Silva Canedo, Denize D’Azambuja Ramos, José Carlos Morais & Cristiane Bedran Milito

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  1. Bruno Augusto Benevenuto de Andrade
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  2. Maria Danielle Fontes
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  3. Ana Luiza Oliveira Corrêa Roza
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  4. Pablo Agustin Vargas
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  5. Michelle Agostini
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  6. Nathalie Henriques Silva Canedo
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  7. Denize D’Azambuja Ramos
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  8. José Carlos Morais
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  9. Cristiane Bedran Milito
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  10. Mário José Romañach
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Correspondence to Bruno Augusto Benevenuto de Andrade.

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All of authors have indicated they have no potential conflicts of interest and no financial relationships relevant to this article to disclose.

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This study was carried out following the Helsinki Declaration for study involving human subjects.

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de Andrade, B.A.B., Fontes, M.D., Roza, A.L.O.C. et al. Anaplastic Large Cell Lymphoma with Oral Manifestation: A Series of Four Cases and Literature Review. Head and Neck Pathol 14, 991–1000 (2020). https://doi.org/10.1007/s12105-020-01176-6

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  • DOI: https://doi.org/10.1007/s12105-020-01176-6

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