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The Prognosis of Type III Biliary Atresia with Hilar Cyst

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Abstract

Objective

To compare the outcome of biliary atresia (BA) patients with and without hilar cyst on preoperative ultrasound.

Methods

A single center retrospective review of patients of BA with (n = 27) and without hilar cyst (n = 27) over a 5 y period was done. The patients were analyzed using propensity score matching to reduce selection bias. All patients were diagnosed as type III BA by histologic examination and cholangiograms. Clinicopathological characteristics and survival outcomes were compared between the two groups.

Results

There were no significant intergroup differences between baseline characteristics and outcomes after Kasai portoenterostomy surgery in two groups. BA with hilar cyst group showed comparable survival outcomes to the BA without cyst group (cumulative 1-y, 2-y and 5-y overall survival rates with native liver 61.4% vs. 65.8%, P = 0.041; 45.0% vs. 49.0%, P = 0.57; 45.0% vs. 49.0%, P = 0.57). And the Kaplan–Meier survival curves showed no significant difference in cumulative survival with native liver between the two groups (P = 0.58).

Conclusions

Type III BA with hilar cyst had no better prognosis compared with Type III BA without cyst.

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Funding

This study was funded by National Natural Science Foundation of China (NO: 81501480 & NO: 81530055) and Natural Science Foundation of Guangdong province (NO: 2015A030313060).

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Authors and Affiliations

  1. Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou, 510080, China

    Quan-yuan Shan, Bao-xian Liu, Xiao-yan Xie, Wen-ying Zhou & Lu-yao Zhou

  2. Department of Pediatric Surgery, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou, 510080, China

    Zhi-hai Zhong, Hua-dong Chen & Hong Jiang

  3. Department of General Surgery, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou, 510080, China

    Yu Guo

Authors
  1. Quan-yuan Shan
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  2. Bao-xian Liu
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  3. Zhi-hai Zhong
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  4. Hua-dong Chen
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  5. Yu Guo
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  6. Xiao-yan Xie
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  7. Wen-ying Zhou
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  8. Hong Jiang
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  9. Lu-yao Zhou
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Corresponding authors

Correspondence to Hong Jiang or Lu-yao Zhou.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Shan, Qy., Liu, Bx., Zhong, Zh. et al. The Prognosis of Type III Biliary Atresia with Hilar Cyst. Indian J Pediatr 88, 650–655 (2021). https://doi.org/10.1007/s12098-020-03561-z

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  • DOI: https://doi.org/10.1007/s12098-020-03561-z

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