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Essential role of aerobic glycolysis in epithelial-to-mesenchymal transition during carcinogenesis

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Abstract

Epithelial-to-mesenchymal transition (EMT) confers the most lethal characteristics to cancer cells i.e., metastasis and resistance to chemo-and-radio-therapy, and therefore exhibit an appealing target in the field of oncology. Research in the past decade has demonstrated the crucial role of aerobic glycolysis in EMT, which is generally credited as the glucose metabolism for the creation of biomass such as fatty acids, amino acids, and nucleotides thereby providing building blocks for limitless proliferation. In the present review, apart from discussing EMT’s evident role in the metastatic process and cancer stemness, we also talked about the vital role of glycolytic enzymes viz. GLUTs, HKs, PGI, PFK-1, aldolase, enolase, PK, LDHA, etc. in the induction of the EMT process in cancerous cells.

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Fig. 1
Fig. 2
Fig. 3

available at https://string-db.org/) webpage, map was created by further grown to obtain 702 interactions (No. of Nodes: 66; No. of Edges: 702; PPI enrichment p-value: < 1.0e–16; and Avg. local clustering co-efficient: 0.738). The network was further refined using Cytoscape version 3.7.2

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Abbreviations

CSCs:

Cancer stem cells

CTCs:

Circulating tumor cells

EMP:

Epithelial mesenchymal plasticity

EMT:

Epithelial-to-mesenchymal transition

EMT-TFs:

EMT-transcription factors

MMPs:

Matrix metalloproteinases

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  1. Department of Medical Oncology (Laboratory), Dr. BRA IRCH, All India Institute of Medical Sciences, 110029, New Delhi, India

    Chandra Prakash Prasad

  2. Department of Medical Oncology, Dr. BRA IRCH, All India Institute of Medical Sciences, 110029, New Delhi, India

    Ajay Gogia & Atul Batra

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Conceptualization: CPP Original draft: CPP Review and editing: AG, AB, and CCP.

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Prasad, C.P., Gogia, A. & Batra, A. Essential role of aerobic glycolysis in epithelial-to-mesenchymal transition during carcinogenesis. Clin Transl Oncol 24, 1844–1855 (2022). https://doi.org/10.1007/s12094-022-02851-6

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