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Comparative Study of Injection Triamcinolone and Hyaluronidase Combination with Injection Platelet Rich Plasma (PRP) in Management of Oral Submucous Fibrosis (OSMF)

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Abstract

This study aimed to compare the results of injection triamcinolone and hyaluronidase combination with injection Platelet Rich Plasma (PRP) in management of Oral Submucous Fibrosis (OSMF). Present study was carried out in randomly divided two groups of 30 patients each of OSMF who all are presented with chief complain of reduced mouth opening. Group A patients were given 1 ml of injection triamcinolone and hyaluronidase combination. Group B patients received 1 ml of injection Platelet Rich Plasma. Both injections were given intralesionally once a week for 6 weeks. Results of ANOVA shows significant better results in improving mouth opening in group B patients receiving injection Platelet Rich Plasma as a treatment. In Group A, patients shows improvement in Maximum interincisal distance (MIID) of mean 6.51 ± 1.02 mm as compared to the patients in group B shows improvement in MIID of mean 9.53 ± 1.06 mm (p value < 0.05). Treatment of OSMF with injection Platelet Rich Plasma is a novel method and found to be more efficient than treatment with injection triamcinolone and hyaluronidase combination.

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Authors and Affiliations

  1. Netaji Subhash Chandra Bose Medical College, Jabalpur, MP, Plot No 97, Ayyappa Nagar, Kohka, Bhilai, Durg, CG, 490023, India

    Deepankar Chandrakapure, Kajal Agarwal & Amrita Shukla

  2. Department of ENT, Netaji Subhash Chandra Bose Medical College, Jabalpur, India

    Kavita Sachdeva

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  1. Deepankar Chandrakapure
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  2. Kavita Sachdeva
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Correspondence to Deepankar Chandrakapure.

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Chandrakapure, D., Sachdeva, K., Agarwal, K. et al. Comparative Study of Injection Triamcinolone and Hyaluronidase Combination with Injection Platelet Rich Plasma (PRP) in Management of Oral Submucous Fibrosis (OSMF). Indian J Otolaryngol Head Neck Surg 75, 3725–3732 (2023). https://doi.org/10.1007/s12070-023-03912-0

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