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Evaluation of Clinical Profile and Various Treatment Modalities in Oral Sub Mucous Fibrosis in North India: Our Experience

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Abstract

Oral submucous fibrosis is a chronic disease affecting oral cavity and sometimes the pharynx. Etiology seems to be local irritants such as capsaicin, tobacco, areca nut and spicy foods. The main concern in this is the management of trismus and burning sensation of the oral mucosa. The aim of this study was to compare various medical treatment protocol of OSMF. 210 patients were divided randomly in 3 groups. In Group A, patients were given biweekly intralesional Hyaluronidase/Dexamethasone for 6 weeks. Group B patients were given tablet Pentoxifylline 400 mg TDS.Group C patients were given Eprisone hydrochloride. All three groups were given Lycopene 10,000 mcg for period of 6 weeks. All patients were given topical Triamcelone for local application. The examinations for mouth opening were repeated at weekly intervals for a period of 6 weeks.The most common complaint was burning sensation in 75.98% cases, difficulty in mouth opening in77.45% and difficulty in swallowing food in 61.76% cases. Group A showed improvement in 41.17% cases presenting with burning sensation followed by decreased mouth opening 39.70%. Group B showed improvement in 45.58% burning sensation, 17.64% with decreased mouth opening. Group C showed improvement in 48.52% patients having pain with spicy food, 32.35% with decreased mouth opening and 17.64% with difficulty in swallowing. We conclude that patients which received intralesional dexamethasone and hyaluronidase along with oral Lycopene showed better clinical and symptomatic improvement, and at present appears to be best non-surgical treatment.

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References

  1. J Schwartz 1952 Atrophia Idiopathica (tropica) mucosae oris. Demonstrated at the Eleventh International Dental Congress, London, 1952 (cited by Sirsat & Khanolkar) Ind J Med Sci 16 189 197

    Google Scholar 

  2. SG Joshi 1953 Submucous fibrosis of the palate and pillars Ind J Otolaryngol Head Neck Surg 4 1 4

    Google Scholar 

  3. Anuradha CD, Devi CS (1993) Serum protein, ascorbic acid & iron & tissue collagen in oral submucous fibrosis –a preliminary study. Indian J Med Res 98:147–51

    CAS  Google Scholar 

  4. R Rajendran 1994 Oral submucous fibrosis: etiology, pathogenesis, and future research WHO Bull OMS 72 6 985 996

    CAS  Google Scholar 

  5. Hammer JE, Mehta FS, Pindborg JJ, Daftary DK (2016) Altered staining reaction of connective tissues in 53 submucous fibrosis patients. J Dent Res 50(2):388–392. https://doi.org/10.1177/00220345710500024601

    Article  Google Scholar 

  6. LK Sharma AK Gupta RD Mukhija P Nigam 1987 Clinical experience with the use of peripheral vasodilator in oral disorders Int J Oral Maxillo Fac Surg 16 6 695 699

    Article  CAS  Google Scholar 

  7. SS Nichlani MV Jagade A Ganeshan 2011 Benefits of using muscle relaxants in the routine treatment protocol of oral submucosal fibrosis: a pilot study Indian J Otolaryngol Head Neck Surg 63 4 317 320

    Article  Google Scholar 

  8. R Mehrotra HP Singh SC Gupta M Singh S Jain 2011 Pentoxifylline therapy in the management of oral submucous fibrosis Asian Pac J Cancer Prev 12 4 971 974

    Google Scholar 

  9. SR Aziz 2009 Lack of reliable evidence for oral submucous fibrosis treatments Evid Based Dent 10 1 8 9

    Article  Google Scholar 

  10. Gowda BBK, Yathish TR, Sinhasan PS, Naik HK, Somayaji P, Anand D (2011) The response of oral submucous fibrosis to lycopene – a carotenoid antioxidant: a clinicopathological study. J Clin Diag Res 5(4):882–888

    Google Scholar 

  11. RM Borle SR Borle 1991 Management of oral; submucous fibrosis: a conservative approach J Oral Maxillofac Surg 49 8 788 791

    Article  CAS  Google Scholar 

  12. N Elizabeth S Gurumani GA Bala George Tukalan 2014 A comparative study between management of oral submucous fibrosis J Evolut Med Dental Sci 3 47 11344 48

    Article  Google Scholar 

  13. S Goel J Ahmed MP Singh P Nahar 2010 Oral submucous fibrosis: a clinico-histopthological comparative study in population of Southern Rajasthan J Carcinogenesis Mutagenesis 1 108

    Article  Google Scholar 

  14. JJ Pindborg FS Mehta PC Gupta DK Daftary 1968 Prevalance of oral submucous fibrosis among 50,915 Indian villagers Br J Cancer 22 4 646 654

    Article  CAS  Google Scholar 

  15. PA Hayes 1985 Oral submucous fibrosis in a 4-year-old girl Oral Surg Oral Med Oral Pathol 59 5 475 478

    Article  CAS  Google Scholar 

  16. PN Sinor PC Gupta PR Murti RB Bhonsle DK Daftary FS Mehta 1990 A case control study of oral submucous fibrosis with special reference to the aetiologic role of areca nut J Oral Pathol Med 19 2 94 98

    Article  CAS  Google Scholar 

  17. PV Vanaja Reddy NR Wanjari PR Banda 2011 Oral submucous fibrosis: correlation of clinical grading to various habit factors Int J Dent Clin 3 21 24

    Google Scholar 

  18. RB Bhonsle PR Murti DK Daftary PC Gupta FS Mehta PN Sinor 1987 Regional variations in oral submucous fibrosis in India Commun Dent Oral Epidemiol 15 4 225 229

    Article  CAS  Google Scholar 

  19. Gaur SK, Sinha ON, Madan J (2013) A study and evaluation of various modalities of non-surgical treatment in oral submucous fibrosis. Int J Institut Pharm Life Sci 3(5):1–4

    Google Scholar 

  20. A Auluck MP Rosin L Zhang KN Sumanth 2008 Oral submucous fibrosis, a clinically benign but potentially malignant disease: report of 3 cases and review of the literature J Can Dent Assoc 74 8 735 740

    Google Scholar 

  21. JC Paymaster 1956 Cancer of the buccal mucosa. A clinical study in 650 cases in Indian patients Cancer 9 3 431 5

    Article  CAS  Google Scholar 

  22. PN Wahi VL Kapur UK Luthra MC Srivastava 1966 Submucous fibrosis of the oral cavity: histomorphological studies Br J Cancer 20 676 687

    Article  CAS  Google Scholar 

  23. JJ Pindborg FS Mehta PC Gupta DK Daftary 1968 Prevalance of oral submucous fibrosis among 50,915 Indian villagers Br J Cancer 22 4 646 654

    Article  CAS  Google Scholar 

  24. NP Selvam AA Dayanand 2013 Lycopene in the management of oral submucous fibrosis Asian J Pharm Clin Res 6 3 58 61

    Google Scholar 

  25. PK Kakar RK Puri VP Venkatachalam 1985 Oral submucous fibrosis-treatment with hylase J Laryngolotol 99 1 57 59

    Article  CAS  Google Scholar 

  26. L James A Shetty D Rishi M Abraham 2015 Management of oral submucous fibrosis with injection of hyaluronidase and dexamethasone in grade III oral submucous fibrosis: a retrospective study J Int Oral Health 7 8 1 4

    Google Scholar 

  27. Gupta J, Srinivasan SV, Jonathan Daniel M (2012) Efficacy of betamethasone, placental extract and hyaluronidase in the treatment of osmf: a comparative study. e-J. Dent 2(1):132–135

    Google Scholar 

  28. D Singh MC Shashikanth N Misra S Agrawal 2014 Lycopene and intralesional betamethasone injections in the management of oral submucous fibrosis J Indian Acad Oral Med Radiol 26 264 268

    Article  Google Scholar 

  29. R Rajendran V Rani S Shaikh 2006 Pentoxifylline therapy : a new adjunct in the treatment of oral submucous fibrosis Indian J Dent Res 17 190 198

    Article  CAS  Google Scholar 

  30. BJ Chetan UR Hemant K Shah H Valimaa 2013 Vasodilator isoxsuprine alleviates symptoms of oral submucous fibrosis Clin Oral Investig 17 5 1375 1382

    Article  Google Scholar 

  31. S Patil MG Sghaireen S Maheshwari SR Kunsi R Sahu 2015 Comparative study of the efficacy of Lycopene and Aloe Vera in the treatment of oral submucous fibrosis Int J Health Allied Sci 4 13 17

    Article  CAS  Google Scholar 

  32. M Singh HS Niranjan R Mehrotra D Shrama SC Gupta 2010 Efficacy of hydrocortisone acetate/hyluronidase vs trimcinoloneacetonide/hyaluronidase in the treatment of oral submucous fibrosis Indian J Med Res 131 665

    CAS  Google Scholar 

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Funding

No funding was received by the authors for this study.

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Authors and Affiliations

  1. Department of ENT, Integral Institute of Medical Sciences & Research, Lucknow, Uttar Pradesh, India

    Pankaj Kumar Verma

  2. Department of Otolaryngology and Head Neck Surgery, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India

    Amit Kumar Rana

  3. Department of Pedodontics, Career Post Graduate Institute of Dental Sciences and Hospital, Lucknow, Uttar Pradesh, India

    Swati Tripathi

  4. Department of ENT, Career Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

    Shivesh Kumar

  5. Department of Community Medicine, Rohilkhand Medical College & Hospital, Bareilly, Uttar Pradesh, India

    Deepak Upadhyay

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  1. Pankaj Kumar Verma
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  2. Amit Kumar Rana
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  3. Swati Tripathi
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  4. Shivesh Kumar
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  5. Deepak Upadhyay
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Correspondence to Amit Kumar Rana.

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Ethical clearance was given by the institutional ethics committee for this study in accordance with the 1964 Helsinki Declaration.

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A written informed consent was taken by all study participants taking permission for participation and publication of their data.

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Verma, P.K., Rana, A.K., Tripathi, S. et al. Evaluation of Clinical Profile and Various Treatment Modalities in Oral Sub Mucous Fibrosis in North India: Our Experience. Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 6313–6320 (2022). https://doi.org/10.1007/s12070-021-03049-y

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  • DOI: https://doi.org/10.1007/s12070-021-03049-y

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