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The emerging role of breast cancer derived extracellular vesicles-mediated intercellular communication in ovarian cancer progression and metastasis

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Abstract

Breast cancer is one of the most occurring cancer types in women worldwide and metastasizes to several organs such as bone, lungs, liver, brain, and ovaries. Extracellular vesicles (EVs) mediate intercellular signaling which has a profound effect on tumor development and metastasis. Recent developments in the field of EVs provide an opportunity to investigate the roles of EVs released from tumor cells in metastasis. In this study, we compared the effects of metastatic breast cancer-derived EVs on both nonluteinized granulosa HGrC1 and ovarian cancer OVCAR-3 cells in terms of proliferation, invasion, apoptosis, and gene expression levels. EVs were isolated from the culture medium of metastatic breast cancer cell line MDA-MB-231 by ultracentrifugation. Cell proliferation, apoptosis, cell cycle, invasion, and cellular uptake analysis were performed to clarify the roles of tumor-derived EVs in both cells. 6.85 × 108 nanoparticles of BCD-EVs were markedly increased cell proliferation as well as invasion capacity. Exposing the cells with BCD-EVs for 24 h, resulted in an accumulation of both cells in G2/M phase as determined by flow cytometry. The apoptosis assay results were consistent with cell proliferation and cell cycle results. The uptake of the BCD-EVs was efficiently internalized by both cells. In addition, marked variations in fatty acid composition between cells were observed. BCD-EVs appeared new fatty acids in HGrC1. Besides, BCD-EVs upregulated epithelial-mesenchymal transition (EMT) and proliferation-related genes. In conclusion, an environment of tumor-derived EVs changes the cellular phenotype of cancer and noncancerous cells and may lead to tumor progression and metastasis.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

We thank Dilek Öztürkoğlu (staff in the Yeditepe University) for their support in the process of lipidomic analysis.

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This study was supported by Yeditepe University.

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Authors and Affiliations

  1. Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 34755, Istanbul, Turkey

    Melis Rahime Yıldırım, Oğuz Kaan Kırbaş & Fikrettin Şahin

  2. Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, İstanbul Sabahattin Zaim University, 34303, Istanbul, Turkey

    Hüseyin Abdik

  3. Department of Genomics, Faculty of Aquatic Sciences, Istanbul University, 34134, Istanbul, Turkey

    Ezgi Avşar Abdik

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Contributions

MRY, HA and EAA designed the study. MRY and OKK performed the experiments. OKK, HA, and EAA analyzed the data. OKK and EAA generated the figures. EAA supervised all experiments. MRY, OKK and EAA wrote the manuscript. MRY, OKK, HA, FŞ, EAA reviewed the manuscript. All authors have read and approved the final manuscript.

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Correspondence to Ezgi Avşar Abdik.

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Yıldırım, M.R., Kırbaş, O.K., Abdik, H. et al. The emerging role of breast cancer derived extracellular vesicles-mediated intercellular communication in ovarian cancer progression and metastasis. Med Oncol 41, 30 (2024). https://doi.org/10.1007/s12032-023-02285-2

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