Abstract
Introduction
Hepatocellular carcinoma (HCC) is a highly complex and deadly cancer. There is an urgent need for new and effective treatment modalities. Since the primary goal in the management of cancer is to cure and improve survival, personalized therapy can increase survival, reduce mortality rates, and improve quality of life. Biobanks hold potential in leading to breakthroughs in biomedical research and precision medicine (PM). They serve as a biorepository, collecting, processing, storing, and supplying specimens and relevant data for basic, translational, and clinical research.
Objective
We aimed to highlight the fundamental role of biobanks, harboring high quality, sustainable collections of patient samples in adequate size and variability, for developing diagnostic, prognostic, and predictive biomarkers to develop and PM approaches in the management of HCC.
Method
We obtained information from previously published articles and BBMRI directory.
Results and Conclusion
Biobanking of high-quality biospecimens along with patient clinical information provides a fundamental scientific infrastructure for basic, translational, and clinical research. Biobanks that control and eliminate pre-analytical variability of biospecimens, provide a platform to identify reliable biomarkers for the application of PM. We believe, establishing HCC biobanks will empower to underpin molecular mechanisms of HCC and generate strategies for PM. Thus, first, we will review current therapy approaches in HCC care. Then, we will summarize challenges in HCC management. Lastly, we will focus on the best practices for establishing HCC biobanking to support research, translational medicine in the light of new experimental research conducted with the aim of delivering PM for HCC patients.
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NA conceived and planned the conceptional framework of the manuscript. NA, PK, and STA wrote the manuscript with the contribution from all authors. YY and YOI contributed to the living biobank and bioinformatics parts of the manuscript, respectively. NA and STA prepared the figures and the tables. All authors discussed the theoretical framework of the manuscript and revised it critically.
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Korhan, P., Tercan Avcı, S., Yılmaz, Y. et al. Role of Biobanks for Cancer Research and Precision Medicine in Hepatocellular Carcinoma. J Gastrointest Canc 52, 1232–1247 (2021). https://doi.org/10.1007/s12029-021-00759-y
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DOI: https://doi.org/10.1007/s12029-021-00759-y