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Effect of polysaccharides from Dictyophora indusiata on regulating gut microbiota and short-chain fatty acids in mice

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Abstract

The gut microbiota, as a special organ, plays a vital role in the health of host and has many functions. Prebiotics are an important group of substances that can promote gut health by regulating the gut microbiota. Polysaccharides are widely distributed in nature with a wide range of biological activities and mushroom-derived polysaccharides have powerful prebiotic potential. Dictyophora indusiata, a saprophytic fungus of the Phallaceae, is known as the “queen of mushrooms” for its attractive appearance and high nutritional value. Modern pharmacology has shown that D. indusiata polysaccharides have various pharmacological activities such as anti-inflammatory, anti-tumor, anti-oxidant and immunomodulatory activities. In our study, we extracted water-soluble and water-insoluble polysaccharides from D. indusiata to act on the mice gut microbiota, and analyzed the data using 16SrRNA high-throughput sequencing and short-chain fatty acids (SCFAs)-based targeted metabolomics. The results showed that both water-soluble and water-insoluble polysaccharides increased intestinal microbial diversity, as well water-insoluble polysaccharides significantly increased the relative abundance of the Lactobacillus and the concentration of SCFAs. In conclusion, D. indusiata polysaccharides have the function of regulating gut microbiota, promoting the generation of SCFAs, and provided us a new insight for the future development of traditional edible mushroom polysaccharides as prebiotic products.

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All data were uploaded to the National Center for Biotechnology Information database (Accession Number: PRJNA839512).

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Acknowledgements

This work supported by Scientific Research Foundation for Talent Introduction of Southwest Medical University (0903-00040031), the Applied Basic Research Cooperation Project of Luzhou Government-Southwest Medical University (2020LZXNYDJ28).

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Authors and Affiliations

  1. School of Pharmacy, Southwest Medical University, 646000, Luzhou, Sichuan, China

    Yong Lai, Qi Fang, Xiurong Guo, Hui Lei, Quan Zhou, Nannan Wu & Can Song

  2. School of Pharmacy, Southwest Medical University, No. 319 Section 3, Zhongshan Road, 646000, Luzhou City, Sichuan Province, China

    Can Song

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  1. Yong Lai
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Lai, Y., Fang, Q., Guo, X. et al. Effect of polysaccharides from Dictyophora indusiata on regulating gut microbiota and short-chain fatty acids in mice. Food Measure 17, 1–11 (2023). https://doi.org/10.1007/s11694-022-01596-8

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