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Volumetric analysis of intravoxel incoherent motion diffusion-weighted imaging in preoperative assessment of non-small cell lung cancer

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the potential of intravoxel incoherent motion (IVIM) and apparent diffusion coefficient (ADC) in the prediction of tumor grade, lymph node metastasis and pleural invasion of non-small cell lung cancer (NSCLC) before surgery.

Materials and Methods

65 patients diagnosed with NSCLC by surgery were enrolled. IVIM-DWI (10 b-values, 0–1000 s/mm2) was performed before surgery. The mean and minimum ADC (ADCmean, ADCmin) and IVIM parameters D, D* and f were independently measured and calculated by 2 radiologists by drawing regions of interest (ROIs) including the solid component of the whole tumor. Intraclass correlation coefficients (ICCs) were analysed. Spearman analysis was used to determine the correlation between IVIM parameters and tumor differentiation. Independent sample t-tests (normal distribution) or Mann–Whitney U tests (non-normal distribution) were used to compare the differences between the parameters in moderately-well and poorly differentiated groups, with and without lymph node metastasis and pleural invasion groups. Receiver operating characteristic (ROC) curves were generated.

Results

The ADCmean, ADCmin, D and f values were negatively correlated with the pathological grades of tumor (P < 0.05). The ADCmean and D values of patients with poor differentiation and lymph node metastasis were significantly lower than that of patients with moderately-well differentiation and without lymph node metastasis (P < 0.001–0.012). The D value was significantly lower and f value was significantly higher among patients with pleural invasion than those without (P =   0.033 and < 0.001). ROC analysis showed that the area under the ROC curve (AUC) was larger for D in predicting the degree of differentiation (0.832) and lymph node metastasis (0.806), and higher for f in predicting pleural invasion (0.832).

Conclusions

IVIM is useful for predicting the tumor differentiation, lymph node metastasis and pleural invasion in NSCLC patients before surgery.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Author notes

  1. Jianqin Jiang and Yigang Fu contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, The Fourth Affiliated Hospital of Nantong University and The First People’s Hospital of Yancheng, No.166 Yulong West Road, Yancheng, 224001, Jiangsu, China

    Jianqin Jiang, Yigang Fu, Lili Zhang & Gaofeng Xu

  2. Department of Radiology, Affiliated Hospital 2 of Nantong University, No. 6 Hai’er Road, Nantong, 226001, Jiangsu, China

    Jia Liu & Lei Cui

  3. Department of Radiology, Suzhou Municipal Hospital, Suzhou, Jiangsu, China

    Xiaowen Gu

  4. Department of Pathology, The Fourth Affiliated Hospital of Nantong University and The First People’s Hospital of Yancheng, Yancheng, Jiangsu, China

    Weiwei Shao

Authors
  1. Jianqin Jiang
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  2. Yigang Fu
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  3. Lili Zhang
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  4. Jia Liu
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  5. Xiaowen Gu
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  8. Gaofeng Xu
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Contributions

All authors contributed to the study conception and design. Conceptualization, methodology were performed by GX and LC. Material preparation, data collection and analysis were performed by JJ, YF, JL, XG, WS. The first draft of the manuscript was written by JJ and YF. The data was verified and proofread by LZ. The manuscript was revised by JJ, YF and LZ. Supervision was performed by GX and LC. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Lei Cui or Gaofeng Xu.

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Jiang, J., Fu, Y., Zhang, L. et al. Volumetric analysis of intravoxel incoherent motion diffusion-weighted imaging in preoperative assessment of non-small cell lung cancer. Jpn J Radiol 40, 903–913 (2022). https://doi.org/10.1007/s11604-022-01279-w

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  • DOI: https://doi.org/10.1007/s11604-022-01279-w

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