Abstract
The label-free, non-destructive information provided by Raman spectroscopy regarding chemical composition, molecular structure, and molecular interaction makes it a potent analytical tool. Raman scattering’s low intensity, however, prevents it from being widely used in a variety of sectors. Plasmonic nanoparticles (NPs) on the surface may considerably improve the Raman process, resulting in surface-enhanced Raman scattering (SERS). Due to the capacity to co-assembling many particles in complicated shapes with fine control of stoichiometry, orientation, and gaps between the particles, the creation of plasmonic nanostructures utilizing a bottom-up method using DNA origami has generated considerable scientific interest. We evaluate current developments in the use of DNA origami structures for the creation of SERS-based sensors in this review paper. We go through SERS fundamentals, plasmonic enhancement processes, and several plasmonic nanostructure fabrication techniques. Additionally, we discuss the benefits of DNA origami in the construction of plasmonic NPs and the creation of SERS hotspots for analytical and medicinal uses. We also discuss potential paths for future research and difficulties facing DNA origami-based SERS sensors. This study attempts to provide a thorough grasp of DNA origami’s potential in the creation of SERS-based sensors and its possibilities for the future.
Similar content being viewed by others
Data Availability
The data used in the present study are available from the corresponding author on reasonable request.
References
Zhang X et al (2012) Label-free live-cell imaging of nucleic acids using stimulated Raman scattering microscopy. Chemphyschem 13(4):1054–1059
Zong C et al (2018) Surface-enhanced Raman spectroscopy for bioanalysis: reliability and challenges. Chem Rev 118(10):4946–4980
Ember KJ et al (2017) Raman spectroscopy and regenerative medicine: a review. NPJ Regen Med 2(1):12
Spiro TG, Gaber BP (1977) Laser Raman scattering as a probe of protein structure. Annu Rev Biochem 46(1):553–570
Taguchi I et al (1987) A Raman scattering study of phonons in RuS2 and RuSe2 single crystals. J Phys C: Solid State Phys 20(26):4241
Fleischmann M, Hendra PJ, McQuillan AJ (1974) Raman spectra of pyridine adsorbed at a silver electrode. Chem Phys Lett 26(2):163–166
Zohar N, Chuntonov L, Haran G (2014) The simplest plasmonic molecules: metal nanoparticle dimers and trimers. J Photochem Photobiol, C 21:26–39
He Q-F et al (2023) Surface-enhanced Raman spectroscopy: principles, methods, and applications in energy systems†. Chin J Chem 41(3):355–369
Karooby E, Granpayeh N (2019) Potential applications of nanoshell bow-tie antennas for biological imaging and hyperthermia therapy. Opt Eng 58(6):065102–065102
Zhu W et al (2016) Quantum mechanical effects in plasmonic structures with subnanometre gaps. Nat Commun 7(1):1–14
Esteban R et al (2015) A classical treatment of optical tunneling in plasmonic gaps: extending the quantum corrected model to practical situations. Faraday Discuss 178:151–183
Salehi K, Kordlu A, Rezapour-Nasrabad R (2020) Prevalence of type 2 diabetes in population over 30 years old (2017–2018). Ethno Med 14(1–2):24–29
Eskandari V, Hadi A (2020) Review of the application and mechanism of surface enhanced Raman spectroscopy (SERS) as biosensor for the study of biological and chemical analyzes. J Comput Appl Mech 51(2):501–509
Rezapour-Nasrabad R (2021) Feasibility of providing Namaste managed care to the elderly with Alzheimer’s disease. Arch Venez de Farmacol y Ter 40(4):455–463
Eskandari V, Hadi A, Sahbafar H (2022) Coating gold nanoparticles to a glass substrate by spin-coat method as a surface-enhanced Raman spectroscopy (SERS) plasmonic sensor to detect molecular vibrations of bisphenol-a (BPA). Adv Nano Res 13(5):417–426
Ganesh S et al (2023) Label-free saliva test for rapid detection of coronavirus using nanosensor-enabled SERS. Bioengineering 10(3):391
Luo Y et al (2023) Active enrichment of nanoparticles for ultra-trace point-of-care COVID-19 detection. Anal Chem 95(12):5316–5322
Eskandari V et al (2022) A review of paper-based substrates as surface-enhanced Raman spectroscopy (SERS) biosensors and microfluidic paper-based SERS platforms. J Comput Appl Mech 53(1):142–156
Vedelago C et al (2023) A multiplexed SERS microassay for accurate detection of SARS-CoV-2 and variants of concern. ACS Sens 8(4):1648–1657
Eskandari V et al (2023) A surface-enhanced Raman scattering (SERS) biosensor fabricated using the electrodeposition method for ultrasensitive detection of amino acid histidine. J Mol Struct 1274
Dang H et al (2023) Nanoplasmonic assay platforms for reproducible SERS detection of Alzheimer’s disease biomarker. Bull Korean Chem Soc 44(5):441. https://doi.org/10.1002/bkcs.12679
Zhou Y et al (2023) Simple plasma test based on a MoSe2 SERS platform for the specific diagnosis of Alzheimer’s disease. Chem Biomed Imaging 1(2):186–191. https://doi.org/10.1021/cbmi.3c00041
Wang J et al (2023) SERS-based detection of early type 1 diabetes mellitus biomarkers: glutamate decarboxylase antibody and insulin autoantibody. Sens Actuators B Chem 381:133456
Cheng Y et al (2023) A SERS/fluorescence dual-mode immuno-nanoprobe for investigating two anti-diabetic drugs on EGFR expressions. Microchim Acta 190(4):124
Mi F et al (2023) A SERS biosensor based on aptamer-based Fe3O4@ SiO2@ Ag magnetic recognition and embedded SERS probes for ultrasensitive simultaneous detection of Staphylococcus aureus and Escherichia coli. Microchem J 190
Eskandari V et al (2023) Liposomes/nanoliposomes and surfaced-enhanced Raman scattering (SERS): a review. Vibrational Spectroscopy p 103536
Zhang Z et al (2023) Engineering rational SERS nanotags for parallel detection of multiple cancer circulating biomarkers. Chemosensors 11(2):110
Cheng Z et al (2023) Application of serum SERS technology based on thermally annealed silver nanoparticle composite substrate in breast cancer. Photodiagnosis Photodyn Ther 41
Eskandari V, Sadeghi M, Hadi A (2021) Physical and chemical properties of nano-liposome, application in nano medicine. J Comput Appl Mech 52(4):751–767
Zhao J et al (2023) SERS-based biosensor for detection of f-PSA%: implications for the diagnosis of prostate cancer. Talanta, p 124654
Ngo L et al (2023) Improving SERS biosensor for the analysis of ovarian cancer-derived small extracellular vesicles. Analyst 148:3074–3086
Liu C et al (2023) Toward SERS-based therapeutic drug monitoring in clinical settings: recent developments and trends. TrAC Trends Anal Chem 117094
Eskandari V et al (2023) Surface-enhanced Raman scattering (SERS) filter paper substrates decorated with silver nanoparticles for the detection of molecular vibrations of acyclovir drug. Spectrochim Acta Part A Mol Biomol Spectrosc 298:122762. https://doi.org/10.1016/j.saa.2023.122762. Epub 2023 Apr 21. PMID: 37130482
Guo Z et al (2023) Detection of heavy metals in food and agricultural products by surface-enhanced Raman spectroscopy. Food Rev Intl 39(3):1440–1461
Eskandari V, Sahbafar H, Hadi A (2022) A review of surface-enhanced Raman biosensors for studying different biological analytes and chemicals. J Lasers Med Sci 18(4):57–57
Esmati M, Hajari N, Eskandari V (2023) Flexible plasmonic paper substrates as surface-enhanced Raman scattering (SERS) biosensors enable sensitive detection of sunitinib malate drug. Plasmonics. https://doi.org/10.1007/s11468-023-01975-x
Karooby E et al (2023) Identification of low concentrations of flucytosine drug using a surface-enhanced Raman scattering (SERS)-active filter paper substrate. Plasmonics. https://doi.org/10.1007/s11468-023-02042-1
Mehmandoust S et al (2023) Experimental and numerical evaluations of flexible filter paper substrates for sensitive and rapid identification of methyl parathion pesticide via surface-enhanced Raman scattering (SERS). Vib Spectrosc 129
Shi Q et al (2023) Soft plasmene helical nanostructures. Adv Mater Technol, pp 2201866
Vieu C et al (2000) Electron beam lithography: resolution limits and applications. Appl Surf Sci 164(1):111–117
Joshi-Imre A, Bauerdick S (2014) Direct-write ion beam lithography. J Nanotechnol 2014:26, Article ID 170415. https://doi.org/10.1155/2014/170415
Sadeghi P et al (2017) Fabrication and characterization of Au dimer antennas on glass pillars with enhanced plasmonic response. Nanophotonics 7(2):497–505
Petti L et al (2016) A plasmonic nanostructure fabricated by electron beam lithography as a sensitive and highly homogeneous SERS substrate for bio-sensing applications. Vib Spectrosc 82:22–30
Near R et al (2012) Pronounced effects of anisotropy on plasmonic properties of nanorings fabricated by electron beam lithography. Nano Lett 12(4):2158–2164
Kinkhabwala A et al (2009) Large single-molecule fluorescence enhancements produced by a bowtie nanoantenna. Nat Photonics 3(11):654–657
Thiruvengadathan R et al (2013) Nanomaterial processing using self-assembly-bottom-up chemical and biological approaches. Rep Prog Phys 76(6)
Tiano AL et al (2010) Solution-based synthetic strategies for one-dimensional metal-containing nanostructures. Chem Commun 46(43):8093–8130
Yang G et al (2017) Self-assembly of large gold nanoparticles for surface-enhanced Raman spectroscopy. ACS Appl Mater Interfaces 9(15):13457–13470
Wang Y-W et al (2016) Large-scale uniform two-dimensional hexagonal arrays of gold nanoparticles templated from mesoporous silica film for surface-enhanced Raman spectroscopy. J Phys Chem C 120(42):24382–24388
Acuna G et al (2012) Fluorescence enhancement at docking sites of DNA-directed self-assembled nanoantennas. Science 338(6106):506–510
Rothemund PW (2006) Folding DNA to create nanoscale shapes and patterns. Nature 440(7082):297–302
Tian Y et al (2015) Prescribed nanoparticle cluster architectures and low-dimensional arrays built using octahedral DNA origami frames. Nat Nanotechnol 10(7):637–644
Seeman NC (1982) Nucleic acid junctions and lattices. J Theor Biol 99(2):237–247
Lang RJ (2007) The science of origami. Phys World 20(2):30
Prinz J et al (2013) DNA origami substrates for highly sensitive surface-enhanced Raman scattering. J Phys Chem Lett 4(23):4140–4145
Chao J et al (2015) DNA-based plasmonic nanostructures. Mater Today 18(6):326–335
Tan SJ et al (2011) Building plasmonic nanostructures with DNA. Nat Nanotechnol 6(5):268–276
Lan X, Wang Q (2014) DNA-programmed self-assembly of photonic nanoarchitectures. NPG Asia Mater 6(4):e97–e97
Sharma J et al (2008) Toward reliable gold nanoparticle patterning on self-assembled DNA nanoscaffold. J Am Chem Soc 130(25):7820–7821
Ding B et al (2010) Gold nanoparticle self-similar chain structure organized by DNA origami. J Am Chem Soc 132(10):3248–3249
Dass M et al (2021) DNA origami-enabled plasmonic sensing. J Phys Chem C 125(11):5969–5981
Kühler P et al (2014) Plasmonic DNA-origami nanoantennas for surface-enhanced Raman spectroscopy. Nano Lett 14(5):2914–2919
Prinz J et al (2016) DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity. Nanoscale 8(10):5612–5620
Simoncelli S et al (2016) Quantitative single-molecule surface-enhanced Raman scattering by optothermal tuning of DNA origami-assembled plasmonic nanoantennas. ACS Nano 10(11):9809–9815
Heck C et al (2017) Gold nanolenses self-assembled by DNA origami. ACS Photonics 4(5):1123–1130
Tanwar S, Haldar KK, Sen T (2017) DNA origami directed Au nanostar dimers for single-molecule surface-enhanced Raman scattering. J Am Chem Soc 139(48):17639–17648
Moeinian A et al (2019) Highly localized SERS measurements using single silicon nanowires decorated with DNA origami-based SERS probe. Nano Lett 19(2):1061–1066
Fang w et al (2019) Quantizing single-molecule surface-enhanced Raman scattering with DNA origami metamolecules. Sci Adv 5(9):eaau4506
Yamashita N et al (2020) Surface-enhanced Raman spectroscopy with gold nanoparticle dimers created by sacrificial DNA origami technique. Micro Nano Lett 15(6):384–389
Chikkaraddy R et al (2021) Dynamics of deterministically positioned single-bond surface-enhanced Raman scattering from DNA origami assembled in plasmonic nanogaps. J Raman Spectrosc 52(2):348–354
Tapio K et al (2021) A versatile DNA origami-based plasmonic nanoantenna for label-free single-molecule surface-enhanced Raman spectroscopy. ACS Nano 15(4):7065–7077
Tanwar S et al (2021) Broadband SERS enhancement by DNA origami assembled bimetallic nanoantennas with label-free single protein sensing. J Phys Chem Lett 12(33):8141–8150
Kogikoski S et al (2021) Raman enhancement of nanoparticle dimers self-assembled using DNA origami nanotriangles. Molecules 26(6):1684
Kaur V, Sharma M, Sen T (2021) DNA origami-templated bimetallic nanostar assemblies for ultra-sensitive detection of dopamine. Front Chem 9
Kabusure KM et al (2022) Optical characterization of DNA origami-shaped silver nanoparticles created through biotemplated lithography. Nanoscale 14(27):9648–9654
Huo B et al (2022) ATP-responsive strand displacement coupling with DNA origami/AuNPs strategy for the determination of microcystin-LR using surface-enhanced Raman spectroscopy. Anal Chem 94(34):11889–11897
Dutta A et al (2022) Molecular states and spin crossover of hemin studied by DNA origami enabled single-molecule surface-enhanced Raman scattering. Nanoscale 14(44):16467–16478
Niu R et al (2021) DNA origami-based nanoprinting for the assembly of plasmonic nanostructures with single-molecule surface-enhanced Raman scattering. Angew Chem 133(21):11801–11807
Chacha M (2021) Surface enhanced Raman scattering of DNA origami-based bowtie shaped silver nanoparticles. Itä-Suomen yliopisto
Hann J et al (2021) DNA origami for biosensor applications, 2021 Smart Systems Integration (SSI), Grenoble, France, pp 1–4. https://doi.org/10.1109/SSI52265.2021.9467014
Zhou C et al (2020) Programming surface-enhanced Raman scattering of DNA origami-templated metamolecules. Nano Lett 20(5):3155–3159
Kaur V et al (2021) DNA-origami-based assembly of Au@ Ag nanostar dimer nanoantennas for label-free sensing of pyocyanin. Chemphyschem 22(2):160–167
Heck C et al (2019) Amorphous carbon generation as a photocatalytic reaction on DNA-assembled gold and silver nanostructures. Molecules 24(12):2324
Zhao M-Z et al (2018) DNA origami-templated assembly of plasmonic nanostructures with enhanced Raman scattering. Nucl Sci Tech 29(1):6
Zhan P et al (2018) DNA origami directed assembly of gold bowtie nanoantennas for single-molecule surface-enhanced Raman scattering. Angew Chem Int Ed 57(11):2846–2850
Heck C et al (2018) Single proteins placed within the SERS hot spots of self-assembled silver nanolenses. Angew Chem Int Ed 57:7444. https://doi.org/10.1002/anie.201801748
Yamashita N et al (2017) Formation of gold nanoparticle dimers on silicon by sacrificial DNA origami technique. Micro Nano Lett 12(11):854–859
Liu B et al (2017) A gold-nanoparticle-based SERS reporter that rolls on DNA origami templates. ChemNanoMat 3(10):760–763
Prinz J et al (2016) Hybrid structures for surface-enhanced Raman scattering: DNA origami/gold nanoparticle dimer/graphene. Small 12(39):5458–5467
Thacker VV et al (2014) DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering. Nat Commun 5(1):3448
Pilo-Pais M et al (2014) Surface-enhanced Raman scattering plasmonic enhancement using DNA origami-based complex metallic nanostructures. Nano Lett 14(4):2099–2104
Wang S et al (2020) DNA origami-enabled biosensors. Sensors (Basel) 20(23):6899. https://doi.org/10.3390/s20236899. PMID: 33287133; PMCID: PMC7731452
Noroozi R et al (2023) 3D and 4D bioprinting technologies: a game changer for the biomedical sector? Ann Biomed Eng 51(8):1683–1712
Farasati Far B et al (2023) Combinational system of lipid-based nanocarriers and biodegradable polymers for wound healing: an updated review. J Funct Biomater 14(2):115
Farasati Far B et al (2022) A review on biomedical application of polysaccharide-based hydrogels with a focus on drug delivery systems. Polymers 14(24):5432
Herrmann A, Haag R, Schedler U (2021) Hydrogels and their role in biosensing applications. Adv Healthcare Mater 10(11):2100062
Farasati Far B et al (2023) An updated review on advances in hydrogel-based nanoparticles for liver cancer treatment. Livers 3(2):161–189
Funding
The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.
Author information
Authors and Affiliations
Contributions
Saeideh Mehmandoust and Vahid Eskandari contributed to the study conception and design. Data collection and analysis of literature were performed by Saeideh Mehmandoust and Vahid Eskandari. The first draft of the manuscript was written by Saeideh Mehmandoust. Elaheh Karooby revised, evaluated, and edited the final version of the manuscript. Moreover, the whole investigation was supervised by Vahid Eskandari. Finally, all authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Ethics Approval
Not applicable.
Competing Interests
The authors declare that there is no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Mehmandoust, S., Eskandari, V. & Karooby, E. A Review of Fabrication of DNA Origami Plasmonic Structures for the Development of Surface-Enhanced Raman Scattering (SERS) Platforms. Plasmonics 19, 1131–1143 (2024). https://doi.org/10.1007/s11468-023-02064-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11468-023-02064-9