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A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene

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Abstract

Biomedical patches play fundamental roles in various applications such as wound closure and tissue regeneration. The hybrid patches integrating versatile properties will prominently improve the therapeutic effects in clinical applications. Herein, an epoxy network loading curcumin and Ti3C2Tx MXenes were developed as a hybrid biomedical patch. The hybrid patch was basically prepared through an epoxy/thiol curing chemistry, and its topological structure can be destructed and rearranged as a vitrimer does due to the active transesterification at high temperature. The resulted hybrid patch exhibits shape-morphing capability, multi-substrate adhesion, self-healing ability, and photothermal effects under 980 nm near infrared (NIR). Additionally, the as-prepared hybrid patch possesses strong UV-shielding, excellent oxidation resistance (ROS scavenging efficiency was 89.3% in 3 min), highly effective antibacterial vitality (more than 99%) against S. aureus and E. coli, and good cytocompatibility. As a proof of concept, the present multifunctional hybrid patch broadens the potential applications in the biomedical field.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China

    Yang Zou, Xin Jin, XiaoPing Zhang, XiaoLing Kong, Qian Zhang, XianHua Xie, ChangJun Liu, WenGuang Liu & Wei Wang

  2. Institutes for Food and Drug Control, Beijing, 100050, China

    LinNan Ke

Authors
  1. Yang Zou
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  2. Xin Jin
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  3. XiaoPing Zhang
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  4. XiaoLing Kong
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  5. Qian Zhang
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  6. XianHua Xie
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  7. ChangJun Liu
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  8. LinNan Ke
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  9. WenGuang Liu
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  10. Wei Wang
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Corresponding authors

Correspondence to WenGuang Liu or Wei Wang.

Additional information

This work was supported by the National Key Research and Development Program (Grant Nos. 2021YFE0105400 and 2016YFC1101202), the Excellent Young Scientists Fund by the National Natural Science Foundation of China (Grant No. 31822020), and the National Natural Science Foundation of China (Grant No. 31870965).

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A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene

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Zou, Y., Jin, X., Zhang, X. et al. A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene. Sci. China Technol. Sci. 64, 2744–2754 (2021). https://doi.org/10.1007/s11431-021-1843-3

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  • DOI: https://doi.org/10.1007/s11431-021-1843-3

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