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Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine

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Abstract

Nanomedicine has become an important development direction of modern medicine, and provides a new way for cancer theranostics. To extend the superior physicochemical property of nanomedicine and enhance their role in cancer theranostics, various strategies have been proposed. Among them, the introduction of oxygen vacancies can enhance the separation of electron-hole pairs and improve the nanomaterials’ catalytic activity, which is beneficial for cancer diagnosis and treatment. This review briefly summarized the formation mechanism and preparation methods of various oxygen vacancy nanomaterials. Then, the effect and application of various oxygen vacancy nanomaterials, such as iron, manganese, titanium, zinc, bismuth, tungsten, cerium, and molybdenum-based nanomaterials in enhancing cancer theranostics were highlighted. At last, the prospect and challenges of oxygen vacancy nanomaterials were discussed. This review provided an overview of the relevant information on oxygen vacancy in cancer theranostics, and further promoted the development of cancer nanomedicine.

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References

  1. Wang Z, Lin R, Huo Y, Li H, Wang L. Adv Funct Mater, 2022, 32: 2109503

    Article  CAS  Google Scholar 

  2. Zu D, Wang H, Lin S, Ou G, Wei H, Sun S, Wu H. Nano Res, 2019, 12: 2150–2163

    Article  CAS  Google Scholar 

  3. Tompkins FC. Nature, 1960, 186: 3–6

    Article  Google Scholar 

  4. Wang M, Shen M, Jin X, Tian J, Li M, Zhou Y, Zhang L, Li Y, Shi J. ACS Catal, 2019, 9: 4573–4581

    Article  CAS  Google Scholar 

  5. Liu S, Gao S, Wang Z, Fei T, Zhang T. Sens Actuat B-Chem, 2019, 290: 493–502

    Article  CAS  Google Scholar 

  6. Kim BS, Bae J, Jeong H, Choe C, Lee H. ACS Catal, 2021, 11: 7154–7159

    Article  CAS  Google Scholar 

  7. Li G, He K, Zhang F, Jiang G, Zhao Z, Zhang Z, Cheng J, Hao Z. Appl Catal B-Environ, 2022, 309: 121231

    Article  CAS  Google Scholar 

  8. Yu H, Li J, Zhang Y, Yang S, Han K, Dong F, Ma T, Huang H. Angew Chem Int Ed, 2019, 58: 3880–3884

    Article  CAS  Google Scholar 

  9. Chen X, Liu L, Yu PY, Mao SS. Science, 2011, 331: 746–750

    Article  CAS  PubMed  Google Scholar 

  10. Zhu C, Li C, Zheng M, Delaunay JJ. ACS Appl Mater Interfaces, 2015, 7: 22355–22363

    Article  CAS  PubMed  Google Scholar 

  11. Li Y’, Gan L, Si R. J Rare Earths, 2021, 39: 43–50

    Article  CAS  Google Scholar 

  12. Hou L, Zhang M, Guan Z, Li Q, Yang J. Appl Surf Sci, 2018, 428: 640–647

    Article  CAS  Google Scholar 

  13. Tong Y, Chen P, Zhang M, Zhou T, Zhang L, Chu W, Wu C, Xie Y. ACS Catal, 2018, 8: 1–7

    Article  Google Scholar 

  14. Chen CF, King G, Dickerson RM, Papin PA, Gupta S, Kellogg WR, Wu G. Nano Energy, 2015, 13: 423–432

    Article  CAS  Google Scholar 

  15. Zhu K, Wu T, Li M, Lu R, Zhu X, Yang W. J Mater Chem A, 2017, 5: 19836–19845

    Article  CAS  Google Scholar 

  16. Mao C, Cheng H, Tian H, Li H, Xiao WJ, Xu H, Zhao J, Zhang L. Appl Catal B-Environ, 2018, 228: 87–96

    Article  CAS  Google Scholar 

  17. Kaczmarczyk J, Zasada F, Janas J, Indyka P, Piskorz W, Kotarba A, Sojka Z. ACS Catal, 2016, 6: 1235–1246

    Article  CAS  Google Scholar 

  18. Zhang Y, Liu Y, Zhang T, Gong X, Wang Z, Liu Y, Wang P, Cheng H, Dai Y, Huang B, Zheng Z. Nano Lett, 2023, 23: 1244–1251

    Article  CAS  PubMed  Google Scholar 

  19. Li J, Wu X, Pan W, Zhang G, Chen H. Angew Chem Int Ed, 2018, 57: 491–495

    Article  Google Scholar 

  20. Li Q, Zhou J, Li D, Ao Z. J Mater Chem A, 2022, 10: 9025–9036

    Article  Google Scholar 

  21. Jeong HY, Jin Y, Yun SJ, Zhao J, Baik J, Keum DH, Lee HS, Lee YH. Adv Mater, 2017, 29: 1605043

    Article  Google Scholar 

  22. Mo S, Zhang Q, Li J, Sun Y, Ren Q, Zou S, Zhang Q, Lu J, Fu M, Mo D, Wu J, Huang H, Ye D. Appl Catal B-Environ, 2020, 264: 118464

    Article  CAS  Google Scholar 

  23. Liu X, Mi J, Shi L, Liu H, Liu J, Ding Y, Shi J, He M, Wang Z, Xiong S, Zhang Q, Liu Y, Wu Z, Chen J, Li J. Angew Chem Int Ed, 2021, 60: 26747–26754

    Article  CAS  Google Scholar 

  24. Xie C, Yan D, Li H, Du S, Chen W, Wang Y, Zou Y, Chen R, Wang S. ACS Catal, 2020, 10: 11082–11098

    Article  CAS  Google Scholar 

  25. Yang W, Su Z’, Xu Z, Yang W, Peng Y, Li J. Appl Catal B-Environ, 2020, 260: 118150

    Article  CAS  Google Scholar 

  26. Li H, Li J, Ai Z, Jia F, Zhang L. Angew Chem Int Ed, 2018, 57: 122–138

    Article  CAS  Google Scholar 

  27. Wei R, Lu Y, Xu Y. Sci China Chem, 2021, 64: 1826–1853

    Article  CAS  Google Scholar 

  28. Liu B, Liu J, Ma S, Zhao Z, Chen Y, Gong XQ, Song W, Duan A, Jiang G. J Phys Chem C, 2016, 120: 2271–2283

    Article  CAS  Google Scholar 

  29. Ma XL, Yang Y, Xu LM, Xiao H, Yao WZ, Li J. J Mater Chem A, 2022, 10: 6146–6152

    Article  CAS  Google Scholar 

  30. Sun C, Kong Y, Shao L, Sun K, Zhang N. J Power Sources, 2020, 459: 228017

    Article  CAS  Google Scholar 

  31. Ai M, Zhang J, Wu Y, Pan L, Shi C, Zou J. Chem Asian J, 2020, 15: 3599–3619

    Article  CAS  PubMed  Google Scholar 

  32. Hao L, Huang H, Zhang Y, Ma T. Adv Funct Mater, 2021, 31: 2100919

    Article  CAS  Google Scholar 

  33. Zhang T, Wu MY, Yan DY, Mao J, Liu H, Hu WB, Du XW, Ling T, Qiao SZ. Nano Energy, 2018, 43: 103–109

    Article  Google Scholar 

  34. Li M, Pan X, Jiang M, Zhang Y, Tang Y, Fu G. Chem Eng J, 2020, 395: 125160

    Article  CAS  Google Scholar 

  35. Gao S, Lin Y, Jiao X, Sun Y, Luo Q, Zhang W, Li D, Yang J, Xie Y. Nature, 2016, 529: 68–71

    Article  CAS  PubMed  Google Scholar 

  36. Cong Q, Chen L, Wang X, Ma H, Zhao J, Li S, Hou Y, Li W. Chem Eng J, 2020, 379: 122302

    Article  CAS  Google Scholar 

  37. Liu H, Fu H, Liu Y, Chen X, Yu K, Wang L. Chemosphere, 2021, 272: 129534

    Article  CAS  PubMed  Google Scholar 

  38. Wang G, Yang Y, Han D, Li Y. Nano Today, 2017, 13: 23–39

    Article  CAS  Google Scholar 

  39. Wang Y, Zhou T, Jiang K, Da P, Peng Z, Tang J, Kong B, Cai WB, Yang Z, Zheng G. Adv Energy Mater, 2014, 4: 1400696

    Article  Google Scholar 

  40. Chen S, Li L, Hu W, Huang X, Li Q, Xu Y, Zuo Y, Li G. ACS Appl Mater Interfaces, 2015, 7: 22999–23007

    Article  CAS  PubMed  Google Scholar 

  41. Yang W, Yang X, Jia J, Hou C, Gao H, Mao Y, Wang C, Lin J, Luo X. Appl Catal B-Environ, 2019, 244: 1096–1102

    Article  CAS  Google Scholar 

  42. Chen S, Huang D, Liu D, Sun H, Yan W, Wang J, Dong M, Tong X, Fan W. Appl Catal B-Environ, 2021, 291: 120065

    Article  CAS  Google Scholar 

  43. Li J, You S, Liu M, Zhang P, Dai Y, Yu Y, Ren N, Zou J. Appl Catal B-Environ, 2020, 265: 118574

    Article  CAS  Google Scholar 

  44. Chen J, Zhu Y, Wu C, Shi J. Chem Soc Rev, 2020, 49: 9057–9094

    Article  CAS  PubMed  Google Scholar 

  45. Zhang X, Xu X, Liu H, Ni N, Liu S, Gong Y, Ma G, Song L, Meng Q, Fan Q, Sun X. Acta Biomater, 2023, 166: 604–614

    Article  CAS  PubMed  Google Scholar 

  46. Ni N, Zhang X, Ma Y, Yuan J, Wang D, Ma G, Dong J, Sun X. Coord Chem Rev, 2022, 458: 214415

    Article  CAS  Google Scholar 

  47. Ni N, Su Y, Wei Y, Ma Y, Zhao L, Sun X. Adv Therap, 2021, 4: 2000218

    Article  CAS  Google Scholar 

  48. Xu S, Pang X, Zhang X, Lv Q, Zhang M, Wang J, Ni N, Sun X. Nano Res, 2023, 16: 7053–7074

    Article  CAS  Google Scholar 

  49. Liu J, Chen Q, Feng L, Liu Z. Nano Today, 2018, 21: 55–73

    Article  Google Scholar 

  50. Zhang X, Ge H, Ma Y, Song L, Ma Y, Tian G, Wang L, Meng Q, Sun X. Chem Eng J, 2023, 455: 140688

    Article  CAS  Google Scholar 

  51. Liu J, Huang M, Zhang X, Hua Z, Feng Z, Dong Y, Sun T, Sun X, Chen C. Coord Chem Rev, 2022, 472: 214785

    Article  CAS  Google Scholar 

  52. Xu R, Xu Z, Si Y, Xing X, Li Q, Xiao J, Wang B, Tian G, Zhu L, Wu Z, Zhang G. ACS Appl Mater Interfaces, 2020, 12: 36917–36927

    Article  CAS  PubMed  Google Scholar 

  53. Zhang R, Liu C, Zhao R, Du Y, Yang D, Ding H, Yang G, Gai S, He F, Yang P. J Colloid Interface Sci, 2022, 623: 155–167

    Article  CAS  PubMed  Google Scholar 

  54. Yuan X, Wang L, Hu M, Zhang L, Chen H, Zhang D, Wang Z, Li T, Zhong M, Xu L, Wang D, Liu Y, Tan W. Angew Chem Int Ed, 2021, 60: 20943–20951

    Article  CAS  Google Scholar 

  55. Wang S, Zhao J, Zhang L, Zhang C, Qiu Z, Zhao S, Huang Y, Liang H. Adv Healthc Mater, 2022, 11: 2102073

    Article  CAS  Google Scholar 

  56. Yu B, Wang W, Sun W, Jiang C, Lu L. J Am Chem Soc, 2021, 143: 8855–8865

    Article  CAS  PubMed  Google Scholar 

  57. Guan S, Wang L, Xu SM, Yang D, Waterhouse GIN, Qu X, Zhou S. Chem Sci, 2018, 10: 2336–2341

    Article  PubMed  PubMed Central  Google Scholar 

  58. Gao C, Guo W, Guo X, Ding Z, Ding Y, Shen XC. Acta Biomater, 2021, 129: 220–234

    Article  CAS  PubMed  Google Scholar 

  59. Karthikeyan C, Sisubalan N, Sridevi M, Varaprasad K, Ghouse Basha MH, Shucai W, Sadiku R. J Hazard Mater, 2021, 411: 124884

    Article  CAS  PubMed  Google Scholar 

  60. Liang S, Deng X, Xu G, Xiao X, Wang M, Guo X, Ma P, Cheng Z, Zhang D, Lin J. Adv Funct Mater, 2020, 30: 1908598

    Article  CAS  Google Scholar 

  61. Zhang DY, Liu H, Younis MR, Lei S, Chen Y, Huang P, Lin J. J Nanobiotechnol, 2022, 20: 53

    Article  CAS  Google Scholar 

  62. Qiao X, Xue L, Huang H, Dai X, Chen Y, Ding H. J. Nanobiotechnol., 2022, 20: 1–17

    Article  Google Scholar 

  63. Liu Y, Wang Y, Zhen W, Wang Y, Zhang S, Zhao Y, Song S, Wu Z, Zhang H. Biomaterials, 2020, 251: 120075

    Article  CAS  PubMed  Google Scholar 

  64. Yang Z, Yuan M, Liu B, Zhang W, Maleki A, Guo B, Ma P, Cheng Z, Lin J. Angew Chem Int Ed, 2022, 61: e202209484

    Article  CAS  Google Scholar 

  65. Wang X, Ma B, Xue J, Wu JF, Chang J, Wu C. Nano Lett, 2019, 19: 2138–2147

    Article  CAS  PubMed  Google Scholar 

  66. Li J, Peng HL, Wen C, Xu P, Shen XC, Gao C. Langmuir, 2022, 38: 5502–5514

    Article  CAS  PubMed  Google Scholar 

  67. Guo X, Wen C, Xu Q, Ruan C, Shen XC, Liang H. J Mater Chem B, 2021, 9: 2042–2053

    Article  CAS  PubMed  Google Scholar 

  68. Zhu C, Ding Z, Guo Z, Guo X, Yang A, Li Z, Jiang BP, Shen XC. Biomater Sci, 2020, 8: 6515–6525

    Article  CAS  PubMed  Google Scholar 

  69. Peng C, Liu J, Guo L, Bai J, Zhou M. Chem Commun, 2020, 56: 11259–11262

    Article  CAS  Google Scholar 

  70. Liu X, Jin Y, Liu T, Yang S, Zhou M, Wang W, Yu H. ACS Biomater Sci Eng, 2020, 6: 4834–4845

    Article  CAS  PubMed  Google Scholar 

  71. Liu X, Liang T, Zhang R, Ding Q, Wu S, Li C, Lin Y, Ye Y, Zhong Z, Zhou M. ACS Appl Mater Interfaces, 2021, 13: 9643–9655

    Article  CAS  PubMed  Google Scholar 

  72. Zhang Z, Niu N, Gao X, Han F, Chen Z, Li S, Li J. Colloids Surfs B-Biointerfaces, 2019, 173: 335–345

    Article  CAS  Google Scholar 

  73. Fu J, Li T, Zhu Y, Hao Y. Adv Funct Mater, 2019, 29: 1906195

    Article  CAS  Google Scholar 

  74. Guo C, Liu X, Gao L, Ma X, Zhao M, Zhou J, Kuang X, Deng W, Sun X, Wei Q. J Mater Chem A, 2019, 7: 21704–21710

    Article  CAS  Google Scholar 

  75. Dostalova S, Cerna T, Hynek D, Koudelkova Z, Vaculovic T, Kopel P, Hrabeta J, Heger Z, Vaculovicova M, Eckschlager T, Stiborova M, Adam V. ACS Appl Mater Interfaces, 2016, 8: 14430–14441

    Article  CAS  PubMed  Google Scholar 

  76. Du Y, Xue J, Sun X, Wu D, Liu X, Ju H, Yang L, Wei Q. Anal Chem, 2020, 92: 8472–8479

    Article  CAS  PubMed  Google Scholar 

  77. Cheng L, Wang X, Gong F, Liu T, Liu Z. Adv Mater, 2020, 32: 1902333

    Article  CAS  Google Scholar 

  78. Giorgio M, Trinei M, Migliaccio E, Pelicci PG. Nat Rev Mol Cell Biol, 2007, 8: 722–728

    Article  CAS  PubMed  Google Scholar 

  79. Gong F, Yang N, Wang Y, Zhuo M, Zhao Q, Wang S, Li Y, Liu Z, Chen Q, Cheng L. Small, 2020, 16: 2003496

    Article  CAS  Google Scholar 

  80. Gong F, Luo L, Yao Y, Dai D, Lu W, Chen W. Chem Eng J, 2016, 304: 440–447

    Article  CAS  Google Scholar 

  81. Kim JK, Park S, Yoo RJ, Jeong HJ, Oh J, Lee YJ, Park S, Kim DW. Chem Eur J, 2018, 24: 3506–3511

    Article  CAS  PubMed  Google Scholar 

  82. Jin X, Yang W, Xu Y, Bian K, Zhang B. View, 2021, 2: 20200141

    Article  Google Scholar 

  83. Ma Z, Jia X, Bai J, Ruan Y, Wang C, Li J, Zhang M, Jiang X. Adv Funct Mater, 2017, 27: 1604258

    Article  Google Scholar 

  84. Yang G, Xu L, Chao Y, Xu J, Sun X, Wu Y, Peng R, Liu Z. Nat Commun, 2017, 8: 902

    Article  PubMed  PubMed Central  Google Scholar 

  85. Pan YX, Sun ZQ, Cong HP, Men YL, Xin S, Song J, Yu SH. Nano Res, 2016, 9: 1689–1700

    Article  CAS  Google Scholar 

  86. Wang L, Guan S, Weng Y, Xu SM, Lu H, Meng X, Zhou S. ACS Appl Mater Interfaces, 2019, 11: 6267–6275

    Article  CAS  PubMed  Google Scholar 

  87. Feng W, Han X, Wang R, Gao X, Hu P, Yue W, Chen Y, Shi J. Adv Mater, 2018, 1805919

  88. Zhang H, Wang T, Qiu W, Han Y, Sun Q, Zeng J, Yan F, Zheng H, Li Z, Gao M. Nano Lett, 2018, 18: 4985–4992

    Article  CAS  PubMed  Google Scholar 

  89. Kim KT, Eo MY, Nguyen TTH, Kim SM. Int J Implant Dent, 2019, 5: 10

    Article  PubMed  PubMed Central  Google Scholar 

  90. Cao Y, Wu T, Dai W, Dong H, Zhang X. Chem Mater, 2019, 31: 9105–9114

    Article  CAS  Google Scholar 

  91. Wang X, Zhong X, Bai L, Xu J, Gong F, Dong Z, Yang Z, Zeng Z, Liu Z, Cheng L. J Am Chem Soc, 2020, 142: 6527–6537

    Article  CAS  PubMed  Google Scholar 

  92. Zhang X, Huang B, Shen Y, Yang C, Huang Z, Huang Y, Xu X, Jiang Y, Sun X, Li X, Yan M, Zhao C. J Mater Chem B, 2018, 6: 2347–2357

    Article  CAS  PubMed  Google Scholar 

  93. Pan X, Yang MQ, Fu X, Zhang N, Xu YJ. Nanoscale, 2013, 5: 3601–3614

    Article  CAS  PubMed  Google Scholar 

  94. Anjum S, Hashim M, Malik SA, Khan M, Lorenzo JM, Abbasi BH, Hano C. Cancers, 2021, 13: 4570

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Boutra B, Güy N, Özacar M, Trari M. J Magn Magn Mater, 2020, 497: 165994

    Article  CAS  Google Scholar 

  96. Peter IJ, Praveen E, Vignesh G, Nithiananthi P. Mater Res Express, 2017, 4: 124003

    Article  Google Scholar 

  97. Fatima H, Jin ZY, Shao Z, Chen XJ. J Colloid Interface Sci, 2022, 621: 440–463

    Article  CAS  PubMed  Google Scholar 

  98. Gupta J, Bahadur D. ACS Omega, 2018, 3: 2956–2965

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Griffith DM, Li H, Werrett MV, Andrews PC, Sun H. Chem Soc Rev, 2021, 50: 12037–12069

    Article  CAS  PubMed  Google Scholar 

  100. Fallone CA, Moss SF, Malfertheiner P. Gastroenterology, 2019, 157: 44–53

    Article  PubMed  Google Scholar 

  101. Zhang C, Ren J, Hua J, Xia L, He J, Huo D, Hu Y. ACS Appl Mater Interfaces, 2018, 10: 1132–1146

    Article  CAS  PubMed  Google Scholar 

  102. Kwong GA, Ghosh S, Gamboa L, Patriotis C, Srivastava S, Bhatia SN. Nat Rev Cancer, 2021, 21: 655–668

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Li Y, Dai X, He L, Bu Y, Ao JP. J Mater Chem B, 2022, 10: 870–879

    Article  PubMed  Google Scholar 

  104. Li H, Shang J, Yang Z, Shen W, Ai Z, Zhang L. Environ Sci Technol, 2017, 51: 5685–5694

    Article  CAS  PubMed  Google Scholar 

  105. Franchina DG, Dostert C, Brenner D. Trends Immunol, 2018, 39: 489–502

    Article  CAS  PubMed  Google Scholar 

  106. Tang Z, Liu Y, He M, Bu W. Angew Chem Int Ed, 2019, 58: 946–956

    Article  CAS  Google Scholar 

  107. Wang S, Wang H, Song C, Li Z, Wang Z, Xu H, Yu W, Peng C, Li M, Chen Z. Nanoscale, 2019, 11: 15326–15338

    Article  CAS  PubMed  Google Scholar 

  108. Fang Q, Xu Y, Luo L, Liu C, Li Z, Lin J, Chen T, Wu A. Regenerat Biomater, 2022, 9: rbac036

    Article  CAS  Google Scholar 

  109. Dai C, Hu R, Wang C, Liu Z, Zhang S, Yu L, Chen Y, Zhang B. Nanoscale Horiz, 2020, 5: 857–868

    Article  CAS  PubMed  Google Scholar 

  110. Valenti G, Scarabino S, Goudeau B, Lesch A, Jović M, Villani E, Sentic M, Rapino S, Arbault S, Paolucci F, Sojic N. J Am Chem Soc, 2017, 139: 16830–16837

    Article  CAS  PubMed  Google Scholar 

  111. Liu S, Yuan H, Bai H, Zhang P, Lv F, Liu L, Dai Z, Bao J, Wang S. J Am Chem Soc, 2018, 140: 2284–2291

    Article  CAS  PubMed  Google Scholar 

  112. Ning Z, Zheng Y, Pan D, Zhang Y, Shen Y. Biosens Bioelectron, 2020, 150: 111945

    Article  CAS  PubMed  Google Scholar 

  113. Pan D, Fang Z, Yang E, Ning Z, Zhou Q, Chen K, Zheng Y, Zhang Y, Shen Y. Angew Chem Int Ed, 2020, 59: 16747–16754

    Article  CAS  Google Scholar 

  114. Dong K, Liu Z, Li Z, Ren J, Qu X. Adv Mater, 2013, 25: 4452–4458

    Article  CAS  PubMed  Google Scholar 

  115. Cong S, Yuan Y, Chen Z, Hou J, Yang M, Su Y, Zhang Y, Li L, Li Q, Geng F, Zhao Z. Nat Commun, 2015, 6: 7800

    Article  CAS  PubMed  Google Scholar 

  116. Li B, Zhang Y, Zou R, Wang Q, Zhang B, An L, Yin F, Hua Y, Hu J. Dalton Trans, 2014, 43: 6244–6250

    Article  CAS  PubMed  Google Scholar 

  117. Wen M, Wang S, Jiang R, Wang Y, Wang Z, Yu W, Geng P, Xia J, Li M, Chen Z. Biomater Sci, 2019, 7: 4651–4660

    Article  CAS  PubMed  Google Scholar 

  118. Jie S, Guo X, Ouyang Z. Int J Nanomed, 2019, Volume 14: 7353–7362

    Article  CAS  Google Scholar 

  119. Ni D, Zhang J, Wang J, Hu P, Jin Y, Tang Z, Yao Z, Bu W, Shi J. ACS Nano, 2017, 11: 4256–4264

    Article  CAS  PubMed  Google Scholar 

  120. Wen L, Chen L, Zheng S, Zeng J, Duan G, Wang Y, Wang G, Chai Z, Li Z, Gao M. Adv Mater, 2016, 28: 5072–5079

    Article  CAS  PubMed  Google Scholar 

  121. Li Z, Li J, Zheng Z, Jiang K, Zheng T, Wang D, Wei H, Shi Z, Li X, Chu H. Sci China Chem, 2022, 65: 877–884

    Article  CAS  Google Scholar 

  122. Vilé G, Colussi S, Krumeich F, Trovarelli A, Pérez-Ramírez J. Angew Chem Int Ed, 2014, 53: 12069–12072

    Article  Google Scholar 

  123. Xu Q, Lei W, Li X, Qi X, Yu J, Liu G, Wang J, Zhang P. Environ Sci Technol, 2014, 48: 9702–9708

    Article  CAS  PubMed  Google Scholar 

  124. Miran HA, Jaf ZN, Altarawneh M, Jiang ZT. Molecules, 2021, 26: 6485

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Montini T, Melchionna M, Monai M, Fornasiero P. Chem Rev, 2016, 116: 5987–6041

    Article  CAS  PubMed  Google Scholar 

  126. Jia H, Ren B, Li M, Liu X, Wu J, Tan X. Solid State Commun, 2018, 277: 45–49

    Article  CAS  Google Scholar 

  127. D’Angelo AM, Webster NAS, Chaffee AL. Inorg Chem, 2016, 55: 12595–12602

    Article  PubMed  Google Scholar 

  128. Di Costanzo A, Scarabino T, Trojsi F, Giannatempo GM, Popolizio T, Catapano D, Bonavita S, Maggialetti N, Tosetti M, Salvolini U, d’Angelo VA, Tedeschi G. Neuroradiology, 2006, 48: 622–631

    Article  PubMed  Google Scholar 

  129. Toy R, Hayden E, Camann A, Berman Z, Vicente P, Tran E, Meyers J, Pansky J, Peiris PM, Wu H, Exner A, Wilson D, Ghaghada KB, Karathanasis E. ACS Nano, 2013, 7: 3118–3129

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. Shao C, Shen A, Zhang M, Meng X, Song C, Liu Y, Gao X, Wang P, Bu W. ACS Nano, 2018, 12: 12629–12637

    Article  CAS  PubMed  Google Scholar 

  131. Zou S, Zhu X, Zhang L, Guo F, Zhang M, Tan Y, Gong A, Fang Z, Ju H, Wu C, Du F. Nanoscale Res Lett, 2018, 13: 76

    Article  PubMed  PubMed Central  Google Scholar 

  132. Moskvin M, Marková I, Malínská H, Miklánková D, Hüttl M, Oliyarnyk O, Pop-Georgievski O, Zhigunov A, Petrovský E, Horák D. Front Chem, 2020, 8: 682

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Atif M, Iqbal S, Fakhar-e-Alam M, Mansoor Q, Alimgeer KS, Fatehmulla A, Hanif A, Yaqub N, Farooq WA, Ahmad S, Ahmad H, Chu Y. Saudi J Biol Sci, 2021, 28: 1233–1238

    Article  CAS  PubMed  Google Scholar 

  134. Pešić M, Podolski-Renić A, Stojković S, Matović B, Zmejkoski D, Kojić V, Bogdanović G, Pavićević A, Mojović M, Savić A, Milenković I, Kalauzi A, Radotić K. Chemico-Biol Interact, 2015, 232: 85–93

    Article  Google Scholar 

  135. de Castro IA, Datta RS, Ou JZ, Castellanos-Gomez A, Sriram S, Daeneke T, Kalantar-zadeh K. Adv Mater, 2017, 29: 1701619

    Article  Google Scholar 

  136. Han C, Yao Y, Cheng X, Luo J, Luo P, Wang Q, Yang F, Wei Q, Zhang Z. Biomacromolecules, 2017, 18: 3776–3787

    Article  CAS  PubMed  Google Scholar 

  137. Liu G, Zhu J, Guo H, Sun A, Chen P, Xi L, Huang W, Song X, Dong X. Angew Chem Int Ed, 2019, 58: 18641–18646

    Article  CAS  Google Scholar 

  138. Wang S, Chen Y, Li X, Gao W, Zhang L, Liu J, Zheng Y, Chen H, Shi J. Adv Mater, 2015, 27: 7117–7122

    Article  CAS  PubMed  Google Scholar 

  139. Pandey S, Sharma KH, Sharma AK, Nerthigan Y, Hang D, Wu H. Chem Eur J, 2018, 24: 7417–7427

    Article  CAS  PubMed  Google Scholar 

  140. Niu W, Chen M, Guo Y, Wang M, Luo M, Cheng W, Wang Y, Lei B. ACS Nano, 2021, 15: 14323–14337

    Article  CAS  PubMed  Google Scholar 

  141. Wang H, Wan K, Shi X. Adv Mater, 2019, 31: 1805368

    Article  CAS  Google Scholar 

  142. Xiong J, Yan J, Li C, Wang X, Wang L, Pan D, Xu Y, Wang F, Li X, Wu Q, Liu J, Liu Y, Liu Q, Zhou Y, Yang M. Chem Eng J, 2021, 416: 129092

    Article  CAS  Google Scholar 

  143. Chen M, Wang M, Niu W, Cheng W, Guo Y, Wang Y, Luo M, Xie C, Leng T, Zhang X, Lin C, Lei B. ACS Appl Mater Interfaces, 2021, 13: 14985–14994

    Article  CAS  PubMed  Google Scholar 

  144. Jiang S, Ji N, Diao X, Li H, Rong Y, Lei Y, Yu Z. ChemSusChem, 2021, 14: 4377–4396

    Article  CAS  PubMed  Google Scholar 

  145. Zheng Y, Fu K, Yu Z, Su Y, Han R, Liu Q. J Mater Chem A, 2022, 10: 14171–14186

    Article  CAS  Google Scholar 

  146. Xie W, Gan Y, Zhang Y’, Wang P, Zhang J, Qian J, Zhang G, Wu Z. J Mater Chem B, 2022, 10: 9613–9621

    Article  CAS  PubMed  Google Scholar 

  147. Xu X, Xu S, Wan J, Wang D, Pang X, Gao Y, Ni N, Chen D, Sun X. Bioactive Mater, 2023, 29: 50–71

    Article  CAS  Google Scholar 

  148. Wheeler KE, Chetwynd AJ, Fahy KM, Hong BS, Tochihuitl JA, Foster LA, Lynch I. Nat Nanotechnol, 2021, 16: 617–629

    Article  CAS  PubMed  Google Scholar 

  149. Idriss H. Chem Catal, 2022, 2: 1549–1560

    Article  CAS  Google Scholar 

  150. Sun X, Cai C, Liu T, Zhang G, Cai D, Xiong S, Wu Z. Anal Methods, 2016, 8: 303–310

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (22104073), the Natural Science Foundation of Shandong (ZR2021QB119, 2022HWYQ-079), and the Youth Innovation Science and Technology Program of Shandong Provincial Universities (2021KJ100).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250000, China

    Yuan Gao, Shuangqing Liu, Hui Liu, Haiyan Ge, Meng Zhang, Chunyu Zhao, Yufang Gong, Xinyu Zhang, Chao Wang & Xiao Sun

  2. Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China

    Zhengyan Wu

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  1. Yuan Gao
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  2. Shuangqing Liu
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  5. Meng Zhang
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  10. Xiao Sun
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  11. Zhengyan Wu
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Correspondence to Chao Wang, Xiao Sun or Zhengyan Wu.

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Gao, Y., Liu, S., Liu, H. et al. Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine. Sci. China Chem. 66, 2492–2512 (2023). https://doi.org/10.1007/s11426-023-1693-8

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  • DOI: https://doi.org/10.1007/s11426-023-1693-8

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