Abstract
A simple electrochemically mediated method for the conversion of nitroarenes to aryl boronic esters is presented. Electrochemical borylation of a diverse range of nitroarenes, including the late-stage borylation of bioactive molecules, is furnished at room temperature under simple conditions, thereby demonstrating the broad utility and functional-group tolerance of this protocol. This transformation provides a convenient and practical access to aryl boronic esters from widely available nitroarenes, which would significantly streamline the synthetic process of diverse functionalized arenes.
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This work was supported by the National Natural Science Foundation of China (21602096).
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Supporting information The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.
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Du, L., Zhang, B., Ji, S. et al. Electrochemical borylation of nitroarenes. Sci. China Chem. 66, 534–539 (2023). https://doi.org/10.1007/s11426-022-1470-8
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DOI: https://doi.org/10.1007/s11426-022-1470-8