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Molecular imaging: design mechanism and bioapplications

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Abstract

Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level, and plays an increasing role in deep understanding of biological processes, early and accurate diagnosis of diseases, and evaluation of treatment. Nowadays, numerous novel molecular imaging probes have been developed, involving every biomedical imaging modality, such as optical imaging, photoacoustic imaging, magnetic resonance imaging, single-photon-emission computed tomography, and positron emission tomography. In this review, we summarize the development of current state-of-the-art molecular imaging probes. We introduce the design strategies of molecular probes and detailed imaging modalities, and highlight the properties of probes and biomedical imaging applications in cells and in vivo, including disease diagnosis, drug tracking, and imaging-guided surgery. Then we discuss the perspectives and challenges in this emerging field. We expect this review could inspire more effective molecular imaging probes to be developed, achieving the goal towards clinical practices.

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Acknowledgements

This work was supported by the National Key R&D Program of China (2020YFA0210800, 2020YFA0909000), the National Natural Science Foundation of China (22176035, U21A20377, 21874024, 21890744, 22107027, 22074036), and Shenzhen Science and Technology Program (RCBS20200714114821377).

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemomet-rics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, 410082, China

    Yifan Lyu, Fengming Chen, Yihao Liu, Wei Li, Yutong Zhang, Qiuling Huang, Zhiqiang Wang, Tiantian Xie, Qiang Zhang, Yingyu Sima, Tianbing Ren, Mengyi Xiong, Lin Yuan, Xiao-Bing Zhang & Weihong Tan

  2. Key Laboratory for Analytical Science of Food Safety and Biology (Ministry of Education), College of Chemistry, Fuzhou University, Fuzhou, 350108, China

    Lanlan Chen, Xuan Zhang, Liting Zheng, Qingqing Li & Huanghao Yang

  3. College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, China

    Ying Wu & Jibin Song

  4. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China

    Weihong Tan

  5. Institute of Molecular Medicine (IMM), State Key Laboratory of Oncogenes and Related Genes Renji Hospital, Shanghai Jiao Tong University School of Medicine, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China

    Ding Ding

  6. College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China

    Ke Li

  7. School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China

    Shuai Xu

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  1. Lanlan Chen
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Corresponding authors

Correspondence to Jibin Song, Lin Yuan, Huanghao Yang, Xiao-Bing Zhang or Weihong Tan.

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The authors declare no conflict of interest.

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Chen, L., Lyu, Y., Zhang, X. et al. Molecular imaging: design mechanism and bioapplications. Sci. China Chem. 66, 1336–1383 (2023). https://doi.org/10.1007/s11426-022-1461-3

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  • DOI: https://doi.org/10.1007/s11426-022-1461-3

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