Abstract
Bioaccessibility (BA) is a crucial factor for evaluating the absorption of pollutants in the human digestion system, which is of vital importance for risk assessment of pollutants via food intake. Multi-pesticides were detected in Dendrobium officinale Kimura et Migo (D. officinale), a popular dual-use plant with both botanical medicine and food applications. Nevertheless, the BA of pesticides in D. officinale remains unknown, restricting its market size. Herein, the BA of 19 pesticides with varying properties was evaluated by using an in vitro digestion model, showing BA values between 27.4 and 96.8%. The BA was controlled by the hydrophobicity and water solubility of pesticides, since the significant correlation between these two factors and BA values was observed. Moreover, co-ingested food ingredients could influence the BA, wherein the effect was significant for pesticides of logKow values no less than 3. Lipids enhanced the BA by 9–66%, whereas proteins or carbohydrates decreased BA values by 6–28%. In particular, considering the BA, the risk quotient values were reduced by 3–73%. Clearly, this work suggested that traditional risk assessment without considering the BA would seriously overestimate the actual risk of pesticides in food.
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Acknowledgements
We thank the National Natural Science Foundation of China (21806143) and Zhejiang Province Public Welfare Technology Application Research Project (LGN19C140010). The authors also thank the anonymous reviewers for their valuable comments and suggestions on this work.
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Jianzhong Yu: Methodology, writing—original draft preparation. Zhenlan Xu: conceptualization and writing—review and editing. Ji Sun: investigation. Xiaoyan Xu: investigation. Yuyong Wu: investigation. Fengting Sun: visualization. Ningning Sang: method validation. Xinwang Lv: software. Changpeng Zhang: language. Xueping Zhao: project administration. Tao Tang: supervision.
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Yu, ., Xu, Z., Sun, J. et al. In vitro assessment of the pesticide bioaccessibility in Dendrobium officinale Kimura et Migo. Environ Sci Pollut Res 30, 91945–91955 (2023). https://doi.org/10.1007/s11356-023-28813-1
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DOI: https://doi.org/10.1007/s11356-023-28813-1