Skip to main content

Advertisement

SpringerLink
Log in

Epigenetics and the role of nutraceuticals in health and disease

  • Review Article
  • Published:
Environmental Science and Pollution Research Aims and scope Submit manuscript

Abstract

In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding understanding of epigenetic mechanisms, as well as widespread acceptance of their hypothesized role in disease induction, facilitated the development of a number of novel diagnostic markers and therapeutic concepts. Epigenetic aberrations are reversible in nature, which enables the treatment of serious incurable diseases. Therefore, the interest in epigenetic modulatory effects has increased over the last decade, so about 60,000 publications discussing the expression of epigenetics could be detected in the PubMed database. Out of these, 58,442 were published alone in the last 10 years, including 17,672 reviews (69 historical articles), 314 clinical trials, 202 case reports, 197 meta-analyses, 156 letters to the editor, 108 randomized controlled trials, 87 observation studies, 40 book chapters, 22 published lectures, and 2 clinical trial protocols. The remaining publications are either miscellaneous or a mixture of the previously mentioned items. According to the species and gender, the publications included 44,589 human studies (17,106 females, 14,509 males, and the gender is not mentioned in the remaining papers) and 30,253 animal studies. In the present work, the role of epigenetic modulations in health and disease and the influencing factors in epigenetics are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Data availability

Not applicable.

Materials availability

Not applicable.

Code availability

Not applicable.

References

  • Abdelli LS, Samsam A, Naser SA (2019) Propionic acid induces gliosis and neuro-inflammation through modulation of PTEN/AKT pathway in autism spectrum disorder. Sci Rep 9:8824

    Google Scholar 

  • Abdulamir AS, Hafidh RR, Bakar FA (2010) Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8. Mol Cancer 9:249

    Google Scholar 

  • Aggarwal BB (2010) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr 30:173–199

    CAS  Google Scholar 

  • Ahmed HH, Shousha WG, El-Mezayen HA, El-Toumy SA, Sayed AH, Ramadan AR (2017) Biochemical and molecular evidences for the antitumor potential of ginkgo biloba leaves extract in rodents. Acta Biochim Pol 64:25–33

    CAS  Google Scholar 

  • Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W (2016) Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes. Nat Commun 7:11849

    CAS  Google Scholar 

  • Akter J, Hossain MA, Takara K, Islam MZ, Hou D-X (2019) Antioxidant activity of different species and varieties of turmeric (Curcuma spp): isolation of active compounds. Comp Biochem Physiol C: Toxicol Pharmacol 215:9–17

    CAS  Google Scholar 

  • Alam SE, Singh R, Gupta S, Dherange P, De Meester F, Wilczynska A, Dharwadkar S, Wilson D, Hungin P (2012) Nutritional aspects of epigenetic inheritance. Can J Physiol Pharmacol 90:989–994

    CAS  Google Scholar 

  • Alsanea S, Liu D (2017) BITC and S-carvone restrain high-fat diet-induced obesity and ameliorate hepatic steatosis and insulin resistance. Pharm Res 34:2241–2249

    CAS  Google Scholar 

  • Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23:185

    CAS  Google Scholar 

  • An K, Zhao D, Wang Z, Wu J, Xu Y, Xiao G (2016) Comparison of different drying methods on Chinese ginger (Zingiber officinale Roscoe): changes in volatiles, chemical profile, antioxidant properties, and microstructure. Food Chem 197:1292–1300

    CAS  Google Scholar 

  • Anderson DI, Hubbard EM, Campos JJ, Barbu-Roth MA, Witherington D, Hertenstein MJ (2000) Probabilistic epigenesis, experience, and psychological development in infancy. Infancy 1:245–251

    Google Scholar 

  • Andreescu N, Puiu M, Niculescu M (2018) Effects of dietary nutrients on epigenetic changes in cancer, cancer epigenetics for precision medicine. Springer, pp. 121–139

  • Ashley B, Simner C, Rezwan F, Holloway J, Lillycrop K, Harvey N, Lewis R, Cleal J (2017) Short term vitamin D exposure alters methylation status of term placental villi. Placenta 57:262

    Google Scholar 

  • Aughey GN, Southall TD (2016) Dam it’s good! DamID profiling of protein-DNA interactions. Wiley Interdiscip Rev Dev Biol 5:25–37

    CAS  Google Scholar 

  • Bak SH, Choi HH, Lee J, Kim MH, Lee YH, Kim JS, Cho Y-S (2017) Fecal microbiota transplantation for refractory Crohn’s disease. Intestinal Res 15:244

    Google Scholar 

  • Baskaradoss J, Geevarghese A, Kutty V (2011) Maternal periodontal status and preterm delivery: a hospital based case–control study. J Periodontal Res 46:542–549

    CAS  Google Scholar 

  • Bauer D, Mazzio E, Hilliard A, Oriaku ET, Soliman KF (2020) Effect of apigenin on whole transcriptome profile of TNFα-activated MDA-MB-468 triple negative breast cancer cells. Oncol Lett 19:2123–2132

    CAS  Google Scholar 

  • Behera AK, Swamy MM, Natesh N, Kundu TK (2016) Garcinol and its role in chronic diseases, Anti-inflammatory Nutraceuticals and Chronic Diseases. Springer, pp. 435–452

  • Benjamin JS, Pilarowski GO, Carosso GA, Zhang L, Huso DL, Goff LA, Vernon HJ, Hansen KD, Bjornsson HT (2017) A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome. Proc Natl Acad Sci 114:125–130

    CAS  Google Scholar 

  • Berman AY, Motechin RA, Wiesenfeld MY, Holz MK (2017) The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precision Oncol 1:1–9

    Google Scholar 

  • Bialonska D, Ramnani P, Kasimsetty SG, Muntha KR, Gibson GR, Ferreira D (2010) The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota. Int J Food Microbiol 140:175–182

    CAS  Google Scholar 

  • Bjornsson HT, Benjamin JS, Zhang L, Weissman J, Gerber EE, Chen Y-C, Vaurio RG, Potter MC, Hansen KD, Dietz HC (2014) Histone deacetylase inhibition rescues structural and functional brain deficits in a mouse model of Kabuki syndrome. Sci Transl Med 6:256ra135

    Google Scholar 

  • Boeke CE, Baccarelli A, Kleinman KP, Burris HH, Litonjua AA, Rifas-Shiman SL, Tarantini L, Gillman M (2012) Gestational intake of methyl donors and global LINE-1 DNA methylation in maternal and cord blood: prospective results from a folate-replete population. Epigenetics 7:253–260

    CAS  Google Scholar 

  • Boksa P (2008) Maternal infection during pregnancy and schizophrenia. J Psychiatry Neurosci: JPN 33:183

    Google Scholar 

  • Boleij A, Tjalsma H (2013) The itinerary of Streptococcus gallolyticus infection in patients with colonic malignant disease. Lancet Infect Dis 13:719–724

    Google Scholar 

  • Bollati V, Baccarelli A (2010) Environmental epigenetics. Heredity 105:105–112

    CAS  Google Scholar 

  • Bomfim MM, Andrade GM, del Collado M, Sangalli JR, Fontes PK, Nogueira MF, Meirelles FV, da Silveira JC, Perecin F (2017) Antioxidant responses and deregulation of epigenetic writers and erasers link oxidative stress and DNA methylation in bovine blastocysts. Mol Reprod Dev 84:1296–1305

    CAS  Google Scholar 

  • Borradaile NM, Wilcox LJ, Edwards JY, Murray WH (2002) Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochem J 366:531–539

    CAS  Google Scholar 

  • Brand S, Teich R, Dicke T, Harb H, Yildirim AÖ, Tost J, Schneider-Stock R, Waterland RA, Bauer U-M, von Mutius E (2011) Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. J Allergy Clin Immunol 128:618-625 e7

    CAS  Google Scholar 

  • Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker EK, Calkin AC, Brownlee M, Cooper ME, El-Osta A (2009) Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes 58:1229–1236

    CAS  Google Scholar 

  • Bridgeman SC, Ellison GC, Melton PE, Newsholme P, Mamotte CDS (2018) Epigenetic effects of metformin: from molecular mechanisms to clinical implications. Diabetes Obes Metab 20:1553–1562

    Google Scholar 

  • Burgio E, Piscitelli P, Migliore L (2018) Ionizing radiation and human health: reviewing models of exposure and mechanisms of cellular damage An epigenetic perspective. Int J Environ Res Public Health 15:1971

    Google Scholar 

  • Byrne MM, Murphy RT, Ryan AW (2014) Epigenetic modulation in the treatment of atherosclerotic disease. Front Gen 5

  • Calvani M, Pasha A, Favre C (2020) Nutraceutical boom in cancer: inside the labyrinth of reactive oxygen species. Int J Mol Sci 21:1936

    CAS  Google Scholar 

  • Campos-Nonato I, Hernandez L, Barquera S (2017) Effect of a high-protein diet versus standard-protein diet on weight loss and biomarkers of metabolic syndrome: a randomized clinical trial. Obes Facts 10:238–251

    CAS  Google Scholar 

  • Cao Y-Y, Yu J, Liu T-T, Yang K-X, Yang L-Y, Chen Q, Shi F, Hao J-J, Cai Y, Wang M-R (2018) Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling. Cell Death Dis 9:17

    Google Scholar 

  • Cao-Lei L, Massart R, Suderman MJ, Machnes Z, Elgbeili G, Laplante DP, Szyf M, King S (2014) DNA methylation signatures triggered by prenatal maternal stress exposure to a natural disaster: Project Ice Storm. PLoS ONE 9:e107653

    Google Scholar 

  • Castillo A (2016) Gene editing using CRISPR-Cas9 for the treatment of lung cancer. Colomb Med 47:178–180

    Google Scholar 

  • Catanzaro M, Corsini E, Rosini M, Racchi M, Lanni C (2018a) Immunomodulators inspired by nature: a review on curcumin and echinacea. Molecules 23:2778

  • Catanzaro M, Corsini E, Rosini M, Racchi M, Lanni C (2018b) Immunomodulators inspired by nature: a review on curcumin and echinacea. Molecules (Basel, Switzerland) 23

  • Cervantes M, Sassone-Corsi P (2019) Modification of histone proteins by serotonin in the nucleus. Nature Publishing Group. 464–465

  • Chan Y, Fish JE, D’Abreo C, Lin S, Robb GB, Teichert A-M, Karantzoulis-Fegaras F, Keightley A, Steer BM, Marsden PA (2004) The cell-specific expression of endothelial nitric-oxide synthase a role for DNA methylation. J Biol Chem 279:35087–35100

    CAS  Google Scholar 

  • Chang L, Liu T, Chai Z, Jie S, Li Z, Liu M, Dong W, Wang X, Zhou B (2018) lincRNA-p21 mediates the anti-cancer effect of ginkgo biloba extract EGb 761 by stabilizing E-cadherin protein in colon cancer. Med Sci Monit: Int Med J Exp Clin Res 24:9488

    CAS  Google Scholar 

  • Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R (1998) DNA hypomethylation leads to elevated mutation rates. Nature 395:89

    CAS  Google Scholar 

  • Chen J-R, Caviness PC, Zhao H, Belcher B, Wankhade UD, Shankar K, Blackburn ML, Lazarenko OP (2022) Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice. Epigenetics 17:2209–2222

    Google Scholar 

  • Chhibber-Goel J, Singhal V, Bhowmik D, Vivek R, Parakh N, Bhargava B, Sharma A (2016) Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients. NPJ Biofilms Microbiomes 2:7

    Google Scholar 

  • Chukwujekwu J, Coombes P, Mulholland D, Van Staden J (2006) Emodin, an antibacterial anthraquinone from the roots of Cassia occidentalis. S Afr J Bot 72:295–297

    CAS  Google Scholar 

  • Ciarlone SL, Grieco JC, D’Agostino DP, Weeber EJ (2016) Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model. Neurobiol Dis 96:38–46

    CAS  Google Scholar 

  • Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG (2014) Minireview: gut microbiota: the neglected endocrine organ. Mol Endocrinol (Baltimore, Md.) 28:1221–1238

    Google Scholar 

  • Cloos PA, Christensen J, Agger K, Helin K (2008) Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 22:1115–1140

    CAS  Google Scholar 

  • Cohen JH, Kristal AR, Stanford JL (2000) Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92:61–68

    CAS  Google Scholar 

  • Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325:201–204

    CAS  Google Scholar 

  • Comhaire F, Decleer W (2020) Can the biological mechanisms of ageing be corrected by food supplementation. The concept of health care over sick care. Aging Male 23:1146–1157

  • Cooney CA, Dave AA, Wolff GL (2002) Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 132:2393S-2400S

    CAS  Google Scholar 

  • Coplan J, Chanatry S, Rosenblum L (2017) Persistence of early-life stress on the epigenome: nonhuman primate observations. Ref Mod Neurosci Biobehav Psych 1–9

  • Córdova-Palomera A, Palma-Gudiel H, Fores-Martos J, Tabares-Seisdedos R, Fañanás L (2018) Epigenetic outlier profiles in depression: a genome-wide DNA methylation analysis of monozygotic twins. PLoS ONE 13:e0207754

    Google Scholar 

  • Costa AGV, Garcia-Diaz DF, Jimenez P, Silva PI (2013) Bioactive compounds and health benefits of exotic tropical red–black berries. J Funct Foods 5:539–549

    CAS  Google Scholar 

  • Covington HE, Maze I, LaPlant QC, Vialou VF, Ohnishi YN, Berton O, Fass DM, Renthal W, Rush AJ, Wu EY (2009) Antidepressant actions of histone deacetylase inhibitors. J Neurosci 29:11451–11460

    CAS  Google Scholar 

  • Csoka AB, Szyf M (2009) Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology. Med Hypotheses 73:770–780

    CAS  Google Scholar 

  • Cuevas-Ramos G, Petit CR, Marcq I, Boury M, Oswald E, Nougayrède J-P (2010) Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells. Proc Natl Acad Sci 107:11537–11542

    CAS  Google Scholar 

  • Dahlén EM, Tengblad A, Länne T, Clinchy B, Ernerudh J, Nystrom F, Östgren C (2014) Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes. Diabetes Metab 40:76–81

    Google Scholar 

  • Dalfrà MG, Burlina S, Del Vescovo GG, Lapolla A (2020) Genetics and epigenetics: new insight on gestational diabetes mellitus. Front Endocrinol 11:602477

    Google Scholar 

  • Das L, Vinayak M (2015) Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer. PloS One 10:e0124000

  • David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA (2014) Diet rapidly and reproducibly alters the human gut microbiome. Nature 505:559

    CAS  Google Scholar 

  • Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB (2016) Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Am J Stem Cells 5:11

    CAS  Google Scholar 

  • Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T (2014) Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet 10:e1004160

    Google Scholar 

  • De Rycke M, Liebaers I, Van Steirteghem A (2002) Epigenetic risks related to assisted reproductive technologies: risk analysis and epigenetic inheritance. Hum Reprod 17:2487–2494

    Google Scholar 

  • Deiuliis J, Mihai G, Zhang J, Taslim C, Varghese J, Maiseyeu A, Huang K, Rajagopalan S (2014) Renin-sensitive microRNAs correlate with atherosclerosis plaque progression. J Hum Hypertens 28:251

    CAS  Google Scholar 

  • del Pozo CH, Garreta E, Belmonte JCI, Montserrat N (2018) Modeling epigenetic modifications in renal development and disease with organoids and genome editing. Dis Mod Mech 11:dmm035048

  • Dénes MI, Borz C, Török Á, Kántor T, Nădășan V, Csibi M, Ábrám Z (2016) The role of smoking in the development of colorectal cancer. Acta Medica Marisiensis 62:400–402

    Google Scholar 

  • Devaux CA, Raoult D (2018) The microbiological memory, an epigenetic regulator governing the balance between good health and metabolic disorders. Front Microbiol 9:1379

    Google Scholar 

  • Diaz-Gerevini GT, Repossi G, Dain A, Tarres MC, Das UN, Eynard AR (2016) Beneficial action of resveratrol: how and why? Nutrition 32:174–178

    CAS  Google Scholar 

  • Dippold RP, Vadigepalli R, Gonye GE, Patra B, Hoek JB (2013) Chronic ethanol feeding alters mi RNA expression dynamics during liver regeneration. Alcoholism: Clin Exp Res 37:59–69

    Google Scholar 

  • Djuric Z, Chen G, Doerge DR, Heilbrun LK, Kucuk O (2001) Effect of soy isoflavone supplementation on markers of oxidative stress in men and women. Cancer Lett 172:1–6

    CAS  Google Scholar 

  • Du L, Xie Z, Wu L-c, Chiu M, Lin J, Chan KK, Liu S, Liu Z (2012) Reactivation of RASSF1A in breast cancer cells by curcumin. Nutr Cancer 64:1228–1235

    CAS  Google Scholar 

  • Duncan SH, Belenguer A, Holtrop G, Johnstone AM, Flint HJ, Lobley GE (2007) Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol 73:1073–1078

    CAS  Google Scholar 

  • Dunne JP, Richard G, Keane J (2015) Commercially available, FDA-approved epigenetic modifiers as therapeutic agents in bacterial infection. Clin Anti-Inflamm Anti-Allergy Drugs 2:79–88

    CAS  Google Scholar 

  • Egger G, Liang G, Aparicio A, Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429:457

    CAS  Google Scholar 

  • Elliott HR, Sharp GC, Relton CL, Lawlor DA (2019) Epigenetics and gestational diabetes: a review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction. Diabetologia 62:2171–2178

    Google Scholar 

  • El-Rayes BF, Ali S, Ali IF, Philip PA, Abbruzzese J, Sarkar FH (2006) Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-κB. Can Res 66:10553–10559

    CAS  Google Scholar 

  • Evans LW, Bender A, Burnett L, Godoy L, Shen Y, Staten D, Zhou T, Angermann JE, Ferguson BS (2020) Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy. J Nutr Biochem 108339

  • Evrensel A, Ceylan ME (2016) Fecal microbiota transplantation and its usage in neuropsychiatric disorders. Clin Psychopharmacol Neurosci 14:231

    Google Scholar 

  • Fang MZ, Chen D, Sun Y, Jin Z, Christman JK, Yang CS (2005) Reversal of hypermethylation and reactivation of p16INK4a, RARβ, and MGMT genes by genistein and other isoflavones from soy. Clin Cancer Res 11:7033–7041

    CAS  Google Scholar 

  • Farivar S, Aghamaleki FS (2018) Effects of major epigenetic factors on systemic lupus erythematosus. Iran Biomed J 22:294

    Google Scholar 

  • Ferrucci V, Boffa I, De Masi G, Zollo M (2016) Natural compounds for pediatric cancer treatment. Naunyn Schmiedebergs Arch Pharmacol 389:131–149

    CAS  Google Scholar 

  • Filkowski JN, Ilnytskyy Y, Tamminga J, Koturbash I, Golubov A, Bagnyukova T, Pogribny IP, Kovalchuk O (2010) Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression. Carcinogenesis 31:1110–1115

    CAS  Google Scholar 

  • Fontelles CC, Carney E, Clarke J, Nguyen NM, Yin C, Jin L, Cruz MI, Ong TP, Hilakivi-Clarke L, De Assis S (2016) Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model. Sci Rep 6:28602

    CAS  Google Scholar 

  • Foster JA, Neufeld K-AM (2013) Gut–brain axis: how the microbiome influences anxiety and depression. Trends Neurosci 36:305–312

    CAS  Google Scholar 

  • Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J (2005a) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci 102:10604–10609

    CAS  Google Scholar 

  • Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K (2005b) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 37:391

    CAS  Google Scholar 

  • Frugé AD, Ptacek T, Tsuruta Y, Morrow CD, Azrad M, Desmond RA, Hunter GR, Rais-Bahrami S, Demark-Wahnefried W (2018) Dietary changes impact the gut microbe composition in overweight and obese men with prostate cancer undergoing radical prostatectomy. J Acad Nutr Diet 118:714-723 e1

    Google Scholar 

  • Fu Q, McKnight RA, Yu X, Wang L, Callaway CW, Lane RH (2004) Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver. Physiol Genomics 20:108–116

    CAS  Google Scholar 

  • Fu Q, Yu X, Callaway CW, Lane RH, McKnight RA (2009) Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene. FASEB J 23:2438–2449

    CAS  Google Scholar 

  • Fuentes F, Paredes-Gonzalez X, Kong A-NT (2015) Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-carbinol/3, 3′-diindolylmethane: antioxidative stress/inflammation, Nrf2, epigenetics/epigenomics and in vivo cancer chemopreventive efficacy. Curr Pharmacol Rep 1:179–196

    CAS  Google Scholar 

  • Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA (2015) Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci 112:E6736–E6743

    CAS  Google Scholar 

  • García-Villalba R, Beltrán D, Espín JC, Selma MV, Tomás-Barberán FA (2013) Time course production of urolithins from ellagic acid by human gut microbiota. J Agric Food Chem 61:8797–8806

    Google Scholar 

  • Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH (2007) Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut 56:1522–1528

    CAS  Google Scholar 

  • Georgikou C, Yin L, Gladkich J, Xiao X, Sticht C, de la Torre C, Gretz N, Gross W, Schäfer M, Karakhanova S (2020) Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer. Cancer Lett 469:238–245

    CAS  Google Scholar 

  • Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR (2011) Epigenetic gene promoter methylation at birth is associated with child’s later adiposity. Diabetes 60:1528–1534

    CAS  Google Scholar 

  • Golombos DM, Ayangbesan A, O’Malley P, Lewicki P, Barlow L, Barbieri CE, Chan C, DuLong C, Abu-Ali G, Huttenhower C (2018) The role of gut microbiome in the pathogenesis of prostate cancer: a prospective, pilot study. Urology 111:122–128

    Google Scholar 

  • Gong X, Marisiddaiah R, Zaripheh S, Wiener D, Rubin LP (2016) Mitochondrial β-carotene 9′, 10′ oxygenase modulates prostate cancer growth via NF-κB inhibition: a lycopene-independent function. Mol Cancer Res 14:966–975

    CAS  Google Scholar 

  • Gonzalo S, Blasco MA (2005) Role of Rb family in the epigenetic definition of chromatin. Cell Cycle 4:752–755

    CAS  Google Scholar 

  • Gregory DJ, Kobzik L, Yang Z, McGuire CC, Fedulov AV (2017) Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy. Am J Physiol-Lung Cell Mol Physiol 313:L395–L405

    Google Scholar 

  • Guillaumet-Adkins A, Yañez Y, Peris-Diaz MD, Calabria I, Palanca-Ballester C, Sandoval J (2017) Epigenetics and oxidative stress in aging. Oxidative Med Cell Longev 9175806

  • Gupta SC, Kim JH, Prasad S, Aggarwal BB (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 29:405–434

    CAS  Google Scholar 

  • Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE, Robson CN (2004) Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 59:177–189

    CAS  Google Scholar 

  • Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost F, Brummer RJ (2008) The role of butyrate on colonic function. Aliment Pharmacol Ther 27:104–119

    CAS  Google Scholar 

  • Han G, Xia J, Gao J, Inagaki Y, Tang W, Kokudo N (2015) Anti-tumor effects and cellular mechanisms of resveratrol. Drug Discov Ther 9:1–12

    CAS  Google Scholar 

  • Hanedan Uslu G, Canyilmaz E, Serdar L, Ersöz Ş (2019) Protective effects of genistein and melatonin on mouse liver injury induced by whole-body ionising radiation. Mol Clin Oncol 10:261–266

    Google Scholar 

  • Hanski L, Genina N, Uvell H, Malinovskaja K, Gylfe Å, Laaksonen T, Kolakovic R, Mäkilä E, Salonen J, Hirvonen J (2014) Inhibitory activity of the isoflavone biochanin A on intracellular bacteria of genus chlamydia and initial development of a buccal formulation. PLoS ONE 9:e115115

    Google Scholar 

  • Hassan FI, Zezi AU, Yaro AH, Danmalam UH (2015) Analgesic, anti-inflammatory and antipyretic activities of the methanol leaf extract of Dalbergia saxatilis Hook. F in rats and mice. J Ethnopharmacol 166:74–78

    Google Scholar 

  • Henikoff S, Greally JM (2016) Epigenetics, cellular memory and gene regulation. Curr Biol 26:R644–R648

    CAS  Google Scholar 

  • Hernandez DG, Nalls MA, Gibbs JR, Arepalli S, van der Brug M, Chong S, Moore M, Longo DL, Cookson MR, Traynor BJ (2011) Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet 20:1164–1172

    CAS  Google Scholar 

  • Hollingsworth JW, Maruoka S, Boon K, Garantziotis S, Li Z, Tomfohr J, Bailey N, Potts EN, Whitehead G, Brass DM (2008) In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Investig 118:3462–3469

    CAS  Google Scholar 

  • Homann N, Tillonen J, Meurman JH, Rintamäki H, Lindqvist C, Rautio M, Jousimies-Somer H, Salaspuro M (2000) Increased salivary acetaldehyde levels in heavy drinkers and smokers: a microbiological approach to oral cavity cancer. Carcinogenesis 21:663–668

    CAS  Google Scholar 

  • Hsu C-N, Wu KL, Lee W-C, Leu S, Chan JY, Tain Y-L (2016) Aliskiren administration during early postnatal life sex-specifically alleviates hypertension programmed by maternal high fructose consumption. Front Physiol 7:299

    Google Scholar 

  • Hu S, Dong TS, Dalal SR, Wu F, Bissonnette M, Kwon JH, Chang EB (2011) The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer. PLoS ONE 6:e16221

    CAS  Google Scholar 

  • Huang J, Plass C, Gerhauser C (2011) Cancer chemoprevention by targeting the epigenome. Curr Drug Targets 12:1925–1956

    CAS  Google Scholar 

  • Hughes LA, van den Brandt PA, De Bruïne AP, Wouters KA, Hulsmans S, Spiertz A, Goldbohm RA, de Goeij AF, Herman JG, Weijenberg MP (2009) Early life exposure to famine and colorectal cancer risk: a role for epigenetic mechanisms. PLoS ONE 4:e7951

    Google Scholar 

  • Hullar MA, Fu BC (2014) Diet, the gut microbiome, and epigenetics. Cancer J (Sudbury, Mass.) 20:170

    CAS  Google Scholar 

  • Hwang J-H, Lim S-B (2015) Antioxidant and anticancer activities of broccoli by-products from different cultivars and maturity stages at harvest. Prev Nutr Food Sci 20:8–14

    Google Scholar 

  • Hyun TK (2020) A recent overview on sulforaphane as a dietary epigenetic modulator. Excli J 19:131

    Google Scholar 

  • Ilnytskyy Y, Kovalchuk O (2011) Non-targeted radiation effects—an epigenetic connection. Mutat Res/Fund Mol Mech Mutagen 714:113–125

    CAS  Google Scholar 

  • Ishida N, Ishihara Y, Ishida K, Tada H, Kato Y, Isoda R, Hagiwara M, Michikawa M, Noguchi T, Matsushita K (2013) Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice. Alzheimer’s Dementia: J Alzheimer’s Assoc 9:P851

    Google Scholar 

  • Ishiura Y, Ishimaru H, Watanabe T, Fujimuro M (2019) Sulforaphane exhibits cytotoxic effects against primary effusion lymphoma cells by suppressing p38MAPK and AKT phosphorylation. Biol Pharm Bull 42:2109–2112

    CAS  Google Scholar 

  • Jahreis S, Trump S, Bauer M, Bauer T, Thürmann L, Feltens R, Wang Q, Gu L, Grützmann K, Röder S (2018) Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications. J Allergy Clin Immunol 141:741–753

    CAS  Google Scholar 

  • Jiménez-Chillarón JC, Díaz R, Martínez D, Pentinat T, Ramón-Krauel M, Ribó S, Plösch T (2012) The role of nutrition on epigenetic modifications and their implications on health. Biochimie 94:2242–2263

    Google Scholar 

  • Johnson AJ, Vangay P, Al-Ghalith GA, Hillmann BM, Ward TL, Shields-Cutler RR, Kim AD, Shmagel AK, Syed AN, Students PMC (2019) Daily sampling reveals personalized diet-microbiome associations in humans. Cell Host Microbe 25:789-802 e5

    CAS  Google Scholar 

  • Kaminsky ZA, Tang T, Wang S-C, Ptak C, Oh GH, Wong AH, Feldcamp LA, Virtanen C, Halfvarson J, Tysk C (2009) DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet 41:240

    CAS  Google Scholar 

  • Kan P-Y, Caterino TL, Hayes JJ (2009) The H4 tail domain participates in intra-and internucleosome interactions with protein and DNA during folding and oligomerization of nucleosome arrays. Mol Cell Biol 29:538–546

    CAS  Google Scholar 

  • Kato M, Natarajan R (2019) Epigenetics and epigenomics in diabetic kidney disease and metabolic memory. Nat Rev Nephrol 15:327–345

  • Keller R, Basta R, Salerno L, Elia M (2017) Autism, epilepsy, and synaptopathies: a not rare association. Neurol Sci 38:1353–1361

    Google Scholar 

  • Kelly JR, Minuto C, Cryan JF, Clarke G, Dinan TG (2017) Cross talk: the microbiota and neurodevelopmental disorders. Front Neurosci 11:490

    Google Scholar 

  • Khader M, Eckl PM (2014) Thymoquinone: an emerging natural drug with a wide range of medical applications. Iran J Basic Med Sci 17:950

    Google Scholar 

  • Khan MA, Tania M, Fu J (2019) Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics. Drug Discov Today 24:2315–2322

  • Khot VV, Chavan-Gautam P, Mehendale S, Joshi SR (2017) Variable methylation potential in preterm placenta: implication for epigenetic programming of the offspring. Reprod Sci 24:891–901

    CAS  Google Scholar 

  • Kim J-H, Kim E-J (2016) Effect of anti-oxidant, anti-inflammatory and anti-invasive of PMA-induced matrix metalloproteinase (MMP-2) and MMP-9 activities of water extract and solvent fractions of Saururus chinensis. J Life Sci 26:584–591

    Google Scholar 

  • Kim T, Park JK, Kim H-J, Chung J-H, Kim JW (2010) Association of histone deacetylase genes with schizophrenia in Korean population. Psychiatry Res 178:266–269

    CAS  Google Scholar 

  • Kim S-M, Park J-H, Lee K-N, Kim S-K, You S-H, Kim T, Tark D, Lee H-S, Seo M-G, Kim B (2015) Robust protection against highly virulent foot-and-mouth disease virus in swine by combination treatment with recombinant adenoviruses expressing porcine alpha and gamma interferons and multiple small interfering RNAs. J Virol 89:8267–8279

    CAS  Google Scholar 

  • Kim YJ, Chung SO, Kim JK, Park SU (2017) Recent studies on resveratrol and its biological and pharmacological activity. Excli J 16:602–608

    Google Scholar 

  • Kim ME, Na JY, Park Y-D, Lee JS (2019) Anti-neuroinflammatory effects of vanillin through the regulation of inflammatory factors and NF-κB signaling in LPS-stimulated microglia. Appl Biochem Biotechnol 187:884–893

    CAS  Google Scholar 

  • Ko M-J, Nam H-H, Chung M-S (2019) Conversion of 6-gingerol to 6-shogaol in ginger (Zingiber officinale) pulp and peel during subcritical water extraction. Food Chem 270:149–155

    CAS  Google Scholar 

  • Krakowsky RH, Tollefsbol TO (2015) Impact of nutrition on non-coding RNA epigenetics in breast and gynecological cancer. Front Nutr 2:16

    Google Scholar 

  • Krautkramer KA, Kreznar JH, Romano KA, Vivas EI, Barrett-Wilt GA, Rabaglia ME, Keller MP, Attie AD, Rey FE, Denu JM (2016) Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues. Mol Cell 64:982–992

    CAS  Google Scholar 

  • Kriebel K, Hieke C, Müller-Hilke B, Nakata M, Kreikemeyer B (2018) Oral biofilms from symbiotic to pathogenic interactions and associated disease–connection of periodontitis and rheumatic arthritis by peptidylarginine deiminase. Front Microbiol 9:53

    Google Scholar 

  • Kumar H, Lund R, Laiho A, Lundelin K, Ley RE, Isolauri E, Salminen S (2014) Gut microbiota as an epigenetic regulator: pilot study based on whole-genome methylation analysis. Mbio 5:e02113-e2114

    CAS  Google Scholar 

  • Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S, Gupta SC, Bharti AC, Aggarwal BB (2018) Chronic diseases, inflammation, and spices: how are they linked? J Transl Med 16:14

    CAS  Google Scholar 

  • Kurkivuori J, Salaspuro V, Kaihovaara P, Kari K, Rautemaa R, Grönroos L, Meurman JH, Salaspuro M (2007) Acetaldehyde production from ethanol by oral streptococci. Oral Oncol 43:181–186

    CAS  Google Scholar 

  • Kurutas EB (2015) The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J 15:71

    Google Scholar 

  • Lagiou P, Sandin S, Weiderpass E, Lagiou A, Mucci L, Trichopoulos D, Adami HO (2007) Low carbohydrate–high protein diet and mortality in a cohort of Swedish women. J Intern Med 261:366–374

    CAS  Google Scholar 

  • Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127:1109–1122

    CAS  Google Scholar 

  • Lanza-Jacoby S, Cheng G (2018) 3, 3′-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species. Pharm Biol 56:407–414

    CAS  Google Scholar 

  • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149:274–293

    CAS  Google Scholar 

  • Lee M, Lin W, Yu B, Lee T (2017) Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals—a review. Asian Australas J Anim Sci 30:299

    CAS  Google Scholar 

  • Lee CM, Lee J, Nam MJ, Park S-H (2018a) Indole-3-carbinol induces apoptosis in human osteosarcoma MG-63 and U2OS cells. Biomed Res Int 2018:7970618

    Google Scholar 

  • Lee S, Lee J, Choi IJ, Kim Y-W, Ryu KW, Kim Y-I, Kim J (2018b) Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population. Sci Rep 8:3823

    Google Scholar 

  • Leung Y-K, Govindarajah V, Cheong A, Veevers J, Song D, Gear R, Zhu X, Ying J, Kendler A, Medvedovic M (2017) Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk. Endocr Relat Cancer 24:345

    Google Scholar 

  • Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng C-W, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J (2014) Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab 19:407–417

    CAS  Google Scholar 

  • Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, Lee D, Bittinger K, Bailey A, Friedman ES, Hoffmann C (2015) Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn’s disease. Cell Host Microbe 18:489–500

    CAS  Google Scholar 

  • Li Y (2018) Epigenetic mechanisms link maternal diets and gut microbiome to obesity in the offspring. Front Genet 9:342

    Google Scholar 

  • Li Y, Go VLW, Sarkar FH (2015a) The role of nutraceuticals in pancreatic cancer prevention and therapy: targeting cellular signaling, miRNAs and epigenome. Pancreas 44:1–10

    Google Scholar 

  • Li Y, Li S, Meng X, Gan R-Y, Zhang J-J, Li H-B (2017) Dietary natural products for prevention and treatment of breast cancer. Nutrients 9:728

    Google Scholar 

  • Liou G-Y, Storz P (2010) Reactive oxygen species in cancer. Free Radical Res 44:479–496

    CAS  Google Scholar 

  • Liu H, Li J, Lu D, Li J, Liu M, He Y, Williams BO, Li J, Yang T (2018a) Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cells. Sci Rep 8:1–13

    Google Scholar 

  • Liu Z, Huang P, Law S, Tian H, Leung W, Xu C (2018b) Preventive effect of curcumin against chemotherapy-induced side-effects. Front Pharmacol 9:1374

  • Luo Q, Yang A, Cao Q, Guan H (2018) 3, 3′-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis. BMC Pharmacol Toxicol 19:71

    CAS  Google Scholar 

  • Lurie I, Yang Y-X, Haynes K, Mamtani R, Boursi B (2015) Antibiotic exposure and the risk for depression, anxiety, or psychosis: a nested case-control study. J Clin Psychiatry 76:1522–1528

    Google Scholar 

  • Lynch R, Diggins EL, Connors SL, Zimmerman AW, Singh K, Liu H, Talalay P, Fahey JW (2017) Sulforaphane from broccoli reduces symptoms of autism: a follow-up case series from a randomized double-blind study. Glob Adv Health Med 6:2164957X17735826

  • Magro DO, Santos A, Guadagnini D, de Godoy FM, Silva SHM, Lemos WJF, Vitulo N, Torriani S, Pinheiro LV, Martinez CAR (2019) Remission in Crohn’s disease is accompanied by alterations in the gut microbiota and mucins production. Sci Rep 9:1–10

    CAS  Google Scholar 

  • Malaspina D, Corcoran C, Kleinhaus K, Perrin M, Fennig S, Nahon D, Friedlander Y, Harlap S (2008) Acute maternal stress in pregnancy and schizophrenia in offspring: a cohort prospective study. BMC Psychiatry 8:71

    CAS  Google Scholar 

  • Manseau MW, Goff DC (2015) Cannabinoids and schizophrenia: risks and therapeutic potential. Neurotherapeutics 12:816–824

    CAS  Google Scholar 

  • Marczylo EL, Amoako AA, Konje JC, Gant TW, Marczylo TH (2012) Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern? Epigenetics 7:432–439

    CAS  Google Scholar 

  • Markus MA, Morris BJ (2008) Resveratrol in prevention and treatment of common clinical conditions of aging. Clin Interv Aging 3:331

    CAS  Google Scholar 

  • Martinez-Arguelles D, Papadopoulos V (2016) Prenatal phthalate exposure: epigenetic changes leading to lifelong impact on steroid formation. Andrology 4:573–584

    CAS  Google Scholar 

  • Martinez-Medina M, Garcia-Gil LJ (2014) Escherichia coli in chronic inflammatory bowel diseases: an update on adherent invasive Escherichia coli pathogenicity. World J Gastrointest Pathophysiol 5:213

    Google Scholar 

  • Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D, Xavier RJ, Teixeira MM, Mackay CR (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282–1286

    CAS  Google Scholar 

  • Masoro EJ (2003) Subfield history: caloric restriction, slowing aging, and extending life. Sci Aging Know Environ SAGE KE 2003:RE2

    Google Scholar 

  • McCubrey JA, Lertpiriyapong K, Steelman LS, Abrams SL, Yang LV, Murata RM, Rosalen PL, Scalisi A, Neri LM, Cocco L (2017) Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging (albany NY) 9:1477

    CAS  Google Scholar 

  • McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT (2012) Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 95:454–464

    CAS  Google Scholar 

  • Meng C, Zhu H, Song H, Wang Z, Huang G, Li D, Ma Z, Ma J, Qin Q, Sun X (2014) Targets and molecular mechanisms of triptolide in cancer therapy. Chin J Cancer Res 26:622

    Google Scholar 

  • Meng X, Li Y, Li S, Zhou Y, Gan R-Y, Xu D-P, Li H-B (2017) Dietary sources and bioactivities of melatonin. Nutrients 9:367

    Google Scholar 

  • Milenkovic D, Berghe WV, Boby C, Leroux C, Declerck K, vel Szic KS, Heyninck K, Laukens K, Bizet M, Defrance M (2014) Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state. PloS one 9:e95527

    Google Scholar 

  • Million M, Alou MT, Khelaifia S, Bachar D, Lagier J-C, Dione N, Brah S, Hugon P, Lombard V, Armougom F (2016) Increased gut redox and depletion of anaerobic and methanogenic prokaryotes in severe acute malnutrition. Sci Rep 6:26051

    CAS  Google Scholar 

  • Mishra S, Singh R, Dwivedi S, Meester FD, Rybar R, Pella D, Fedacko J, Juneja LR (2009) Effects of nutraceuticals on genetic expressions. Open Nutraceut J 2(1)

  • Moon S-K, Choi Y-H, Kim C-H, Choi W-S (2006) p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1. Biochem Biophys Res Commun 350:662–668

    CAS  Google Scholar 

  • Mozos I, Stoian D, Caraba A, Malainer C, Horbańczuk JO, Atanasov AG (2018) Lycopene and vascular health. Front Pharmacol 9:521

  • Mutlu EA, Gillevet PM, Rangwala H, Sikaroodi M, Naqvi A, Engen PA, Kwasny M, Lau CK, Keshavarzian A (2012) Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 302:G966–G978

    CAS  Google Scholar 

  • Myzak MC, Tong P, Dashwood W-M, Dashwood RH, Ho E (2007) Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood, N.J.) 232:227–234

    CAS  Google Scholar 

  • Nabavi SF, Khan H, D’onofrio G, Šamec D, Shirooie S, Dehpour AR, Argüelles S, Habtemariam S, Sobarzo-Sanchez E (2018) Apigenin as neuroprotective agent: of mice and men. Pharmacol Res 128:359–365

    Google Scholar 

  • Nardi I, Reno T, Yun X, Sztain T, Wang J, Dai H, Zheng L, Shen B, Kim J, Raz D (2018) Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to histone H3. Int J Cancer 143:2470–2478

    CAS  Google Scholar 

  • Naserbakht M, Ahmadkhaniha H-R, Mokri B, Smith CL (2011) Advanced paternal age is a risk factor for schizophrenia in Iranians. Ann Gen Psychiatry 10:15

    Google Scholar 

  • Ndiaye M, Philippe C, Mukhtar H, Ahmad N (2011) The grape antioxidant resveratrol for skin disorders: promise, prospects, and challenges. Arch Biochem Biophys 508:164–170

    CAS  Google Scholar 

  • Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng C-P, Huang Y, Haldar S, Verdin E (2017) Ketogenic diet reduces midlife mortality and improves memory in aging mice. Cell Metab 26:547-557 e8

    CAS  Google Scholar 

  • Newsholme P, Haber E, Hirabara S, Rebelato E, Procópio J, Morgan D, Oliveira-Emilio H, Carpinelli AR, Curi R (2007) Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol 583:9–24

    CAS  Google Scholar 

  • Nieminen MT, Uittamo J, Salaspuro M, Rautemaa R (2009) Acetaldehyde production from ethanol and glucose by non-Candidaalbicans yeasts in vitro. Oral Oncol 45:e245–e248

    CAS  Google Scholar 

  • Nitta Y, Kikuzaki H, Ueno H (2007) Food components inhibiting recombinant human histidine decarboxylase activity. J Agric Food Chem 55:299–304

    CAS  Google Scholar 

  • Nosrati N, Bakovic M, Paliyath G (2017) Molecular mechanisms and pathways as targets for cancer prevention and progression with dietary compounds. Int J Mol Sci 18:2050

    Google Scholar 

  • Oak M-H, El Bedoui J, Schini-Kerth VB (2005) Antiangiogenic properties of natural polyphenols from red wine and green tea. J Nutr Biochem 16:1–8

    CAS  Google Scholar 

  • Oh WJ, Jacinto E (2011) mTOR complex 2 signaling and functions. Cell Cycle 10:2305–2316

    CAS  Google Scholar 

  • Olaharski AJ, Rine J, Marshall BL, Babiarz J, Zhang L, Verdin E, Smith MT (2005) The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet 1:e77

    Google Scholar 

  • Omene C, Kalac M, Wu J, Marchi E, Frenkel K, O’Connor OA (2013) Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action. J Cancer Sci Ther 5:334

    Google Scholar 

  • Painter RC, Roseboom TJ, Bleker OP (2005) Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol 20:345–352

    CAS  Google Scholar 

  • Pal S, Tyler JK (2016) Epigen Aging Sci Adv 2:e1600584

    Google Scholar 

  • Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E (2017) The phytochemical 3, 3′-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. J Nutr Biochem 47:113–119

    CAS  Google Scholar 

  • Pan Y, Niles LP (2015) Epigenetic mechanisms of melatonin action in human SH-SY5Y neuroblastoma cells. Mol Cell Endocrinol 402:57–63

    CAS  Google Scholar 

  • Pan F-P, Zhou H-K, Bu H-Q, Chen Z-Q, Zhang H, Xu L-P, Tang J, Yu Q-J, Chu Y-Q, Pan J (2016) Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK. Oncol Rep 35:1941–1949

    CAS  Google Scholar 

  • Paoloni-Giacobino A (2007) Epigenetics in reproductive medicine. Pediatr Res 61:51R

    CAS  Google Scholar 

  • Park JH, Stoffers DA, Nicholls RD, Simmons RA (2008) Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. J Clin Investig 118:2316–2324

    CAS  Google Scholar 

  • Park JH, Yoo Y, Park YJ (2017) Epigenetics: linking nutrition to molecular mechanisms in aging. Prev Nutr Food Sci 22:81

    CAS  Google Scholar 

  • Park YH, Kim J-I, Seo SY, Lee E, Kim HH (2016) Saururus chinensis Baill inhibits proliferation and invasion of human renal cell carcinoma cells through inhibition of inhibitor of apoptosis protein. Chin J Integr Med 1–6. https://doi.org/10.1007/s11655-016-2594-y

  • Pastoriza S, Mesías M, Cabrera C, Rufián-Henares JA (2017) Healthy properties of green and white teas: an update. Food Funct 8:2650–2662

    CAS  Google Scholar 

  • Paul B, Royston KJ, Li Y, Stoll ML, Skibola CF, Wilson LS, Barnes S, Morrow CD, Tollefsbol TO (2017) Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition. PLoS ONE 12:e0189756

    Google Scholar 

  • Pedroso LS, Fávero GM, de Camargo LEA, Mainardes RM, Khalil NM (2013) Effect of the o-methyl catechols apocynin, curcumin and vanillin on the cytotoxicity activity of tamoxifen. J Enzyme Inhib Med Chem 28:734–740

    CAS  Google Scholar 

  • Pellerito C, Morana O, Ferrante F, Calvaruso G, Notaro A, Sabella S, Fiore T (2015) Synthesis, chemical characterization, computational studies and biological activity of new DNA methyltransferases (DNMTs) specific inhibitor. Epigenetic regulation as a new and potential approach to cancer therapy. J Inorg Biochem 150:18–27

    CAS  Google Scholar 

  • Pembrey ME, Bygren LO, Kaati G, Edvinsson S, Northstone K, Sjöström M, Golding J (2006) Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet 14:159

    Google Scholar 

  • Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A (2017) Oxidative stress: harms and benefits for human health. Oxidat Med Cell Longev 8416763

  • Poller W, Tank J, Skurk C, Gast M (2013) Cardiovascular RNA interference therapy: the broadening tool and target spectrum. Circ Res 113:588–602

    CAS  Google Scholar 

  • Prakash D, Kumar N (2011) Cost effective natural antioxidants, nutrients, dietary supplements, and nutriceuticals. Humana Press, New York, 163–188

  • Prasad M, Rajagopal P, Devarajan N, Veeraraghavan VP, Palanisamy CP, Cui B, Patil S, Jayaraman S (2022) A comprehensive review on high fat diet-induced diabetes mellitus: an epigenetic view. J Nutr Biochem 109037

  • Preston MJ, Stylianou J, Zeng MQ, Glover MS, Scheck AC, Woolf MEC, O’Neill K, Syed N (2017) OP16. The ketogenic diet induces epigenetic changes that play key roles in tumour development. Neuro-Oncol 19:28

    Google Scholar 

  • Qin W, Zhu W, Shi H, Hewett JE, Ruhlen RL, MacDonald RS, Rottinghaus GE, Chen Y-C, Sauter ER (2009) Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutr Cancer 61:238–244

    CAS  Google Scholar 

  • Quenstedt M, Parshall A (1998) Prenatal exposure to maternal stress and subsequent schizophrenia. Br J Psychiatry 173:183–183

    CAS  Google Scholar 

  • Quina A, Buschbeck M, Di Croce L (2006) Chromatin structure and epigenetics. Biochem Pharmacol 72:1563–1569

    CAS  Google Scholar 

  • Rangi S, Dhatwalia SK, Bhardwaj P, Kumar M, Dhawan D (2018) Evidence of similar protective effects afforded by white tea and its active component ‘EGCG’on oxidative-stress mediated hepatic dysfunction during benzo (a) pyrene induced toxicity. Food Chem Toxicol 116:281–291

    CAS  Google Scholar 

  • Ratnam DV, Ankola D, Bhardwaj V, Sahana DK, Kumar MR (2006) Role of antioxidants in prophylaxis and therapy: a pharmaceutical perspective. J Control Release 113:189–207

    CAS  Google Scholar 

  • Ray A, Vasudevan S, Sengupta S (2015) 6-Shogaol inhibits breast cancer cells and stem cell-like spheroids by modulation of notch signaling pathway and induction of autophagic cell death. PloS One 10:e0137614

  • Reijerkerk A, Lopez-Ramirez MA, van Het Hof B, Drexhage JA, Kamphuis WW, Kooij G, Vos JB, van der Pouw Kraan TC, van Zonneveld AJ, Horrevoets AJ (2013) MicroRNAs regulate human brain endothelial cell-barrier function in inflammation: implications for multiple sclerosis. J Neurosci 33:6857–6863

    CAS  Google Scholar 

  • Reik W (2007) Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447:425

    CAS  Google Scholar 

  • Reinwald S, Mayer LP, Hoyer PB, Turner CH, Barnes S, Weaver CM (2009) A longitudinal study of the effect of genistein on bone in two different murine models of diminished estrogen-producing capacity. J Osteo 145170

  • Rezasoltani S, Asadzadeh-Aghdaei H, Nazemalhosseini-Mojarad E, Dabiri H, Ghanbari R, Zali MR (2017) Gut microbiota, epigenetic modification and colorectal cancer. Iran J Microbiol 9:55

    Google Scholar 

  • Rodgers AB, Morgan CP, Bronson SL, Revello S, Bale TL (2013) Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. J Neurosci 33:9003–9012

    CAS  Google Scholar 

  • Rosignoli P, Fabiani R, De Bartolomeo A, Spinozzi F, Agea E, Pelli M, Morozzi G (2001) Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells. Carcinogenesis 22:1675–1680

    CAS  Google Scholar 

  • Rozengurt E, Sinnett-Smith J, Kisfalvi K (2010) Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer. Clin Cancer Res 16:2505–2511

    CAS  Google Scholar 

  • Ruiz PA, Braune A, Hölzlwimmer G, Quintanilla-Fend L, Haller D (2007) Quercetin inhibits TNF-induced NF-κ B transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr 137:1208–1215

    CAS  Google Scholar 

  • Ryan D, Henzel K, Pearson B, Siwek M, Papazoglou A, Guo L, Paesler K, Yu M, Müller R, Xie K (2018) A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice. Mol Psychiatry 23:1345

    CAS  Google Scholar 

  • Saadat N, Gupta SV (2012) Potential role of garcinol as an anticancer agent. J Oncol 647206

  • Sahin K, Orhan C, Tuzcu M, Ali S, Sahin N, Hayirli A (2010) Epigallocatechin-3-gallate prevents lipid peroxidation and enhances antioxidant defense system via modulating hepatic nuclear transcription factors in heat-stressed quails. Poult Sci 89:2251–2258

    CAS  Google Scholar 

  • Sanapareddy N, Legge RM, Jovov B, McCoy A, Burcal L, Araujo-Perez F, Randall TA, Galanko J, Benson A, Sandler RS (2012) Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME J 6:1858

    CAS  Google Scholar 

  • Sanctuary MR, Kain JN, Angkustsiri K, German JB (2018) Dietary considerations in autism spectrum disorders: the potential role of protein digestion and microbial putrefaction in the gut-brain axis. Front Nutr 5:40

  • Santini A, Tenore GC, Novellino E (2017) Nutraceuticals: a paradigm of proactive medicine. Eur J Pharm Sci 96:53–61

    CAS  Google Scholar 

  • Saradalekshmi KR, Neetha NV, Sathyan S, Nair IV, Nair CM, Banerjee M (2014) DNA methyl transferase (DNMT) gene polymorphisms could be a primary event in epigenetic susceptibility to schizophrenia. PLoS ONE 9:e98182

    Google Scholar 

  • Sarkar S, Horn G, Moulton K, Oza A, Byler S, Kokolus S, Longacre M (2013) Cancer development, progression, and therapy: an epigenetic overview. Int J Mol Sci 14:21087–21113

    Google Scholar 

  • Sarkar A, Lehto SM, Harty S, Dinan TG, Cryan JF, Burnet PW (2016) Psychobiotics and the manipulation of bacteria–gut–brain signals. Trends Neurosci 39:763–781

    CAS  Google Scholar 

  • Scarpa M, Scarpa M, Barzon L, Costanzi G, Lavezzo E, Finotello F, Erroi F, Dallagnese L, Basato S, Brun P (2014) Mo1791 colonic microbiota and gene methylation in colonic carcinogenesis. Gastroenterology 146:S-1072

    Google Scholar 

  • Schnekenburger M, Diederich M (2015) Nutritional epigenetic regulators in the field of cancer: new avenues for chemopreventive approaches, Epigenetic cancer therapy. Elsevier 393–425

  • Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M, Heber D (2008) Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 56:1415–1422

    CAS  Google Scholar 

  • Semwal RB, Semwal DK, Combrinck S, Viljoen AM (2015) Gingerols and shogaols: important nutraceutical principles from ginger. Phytochemistry 117:554–568

    CAS  Google Scholar 

  • Sender R, Fuchs S, Milo R (2016) Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164:337–340

    CAS  Google Scholar 

  • Sharma P, Kumar J, Garg G, Kumar A, Patowary A, Karthikeyan G, Ramakrishnan L, Brahmachari V, Sengupta S (2008) Detection of altered global DNA methylation in coronary artery disease patients. DNA Cell Biol 27:357–365

    CAS  Google Scholar 

  • Sharma S, Kelly TK, Jones PA (2010) Epigenetics in cancer. Carcinogenesis 31:27–36

    CAS  Google Scholar 

  • Shaterzadeh-Yazdi H, Noorbakhsh M-F, Samarghandian S, Farkhondeh T (2018) An overview on renoprotective effects of thymoquinone. Kidney Diseases 4:74–82

    Google Scholar 

  • Shin EJ, Jo S, Choi H-k, Choi S, Byun S, Lim T-G (2019) Caffeic acid phenethyl ester inhibits UV-induced MMP-1 expression by targeting histone acetyltransferases in human skin. Int J Mol Sci 20:3055

    CAS  Google Scholar 

  • Short A, Fennell K, Perreau VM, Fox A, O’Bryan MK, Kim J, Bredy T, Pang T, Hannan A (2016) Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring. Transl Psychiatry 6:e837

    CAS  Google Scholar 

  • Shukla SD, Lim RW (2013) Epigenetic effects of ethanol on the liver and gastrointestinal system. Alcohol Res: Curr Rev 35:47

    Google Scholar 

  • Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, Bispham J, Thurston A, Huntley JF, Rees WD, Maloney CA (2007) DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci 104:19351–19356

    CAS  Google Scholar 

  • Singh RB, Singh A, Alam SE, Meester FD, Fedacko J, Dharwadkar SM, Juneja LR, Wilson DW (2013) Effects of omega-3 fatty acids on genetic expressions, Omega-6/3 Fatty Acids. Sustain Strat Perspect 27–50

  • Sluijs I, Beulens JW, Spijkerman AM, Grobbee DE, van der Schouw YT (2009) Dietary intake of total, animal, and vegetable protein and risk of type 2 diabetes in the EPIC-NL study. Diab Care 33:43–48

  • Smith K (2017) Epigenome: the symphony in your cells. Nat News https://doi.org/10.1038/d41586-019-00374-9

  • Sobhani I, TranVanNhieu J (2013) Colon cancer is associated with microbial dysbiosis in humans and animals. Govaresh 18:45–56

    CAS  Google Scholar 

  • Sobhani I, Tap J, Roudot-Thoraval F, Roperch JP, Letulle S, Langella P, Corthier G, Van Nhieu JT, Furet JP (2011) Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS ONE 6:e16393

    CAS  Google Scholar 

  • Song J, Noh JH, Lee JH, Eun JW, Ahn YM, Kim SY, Lee SH, Park WS, Yoo NJ, Lee JY (2005) Increased expression of histone deacetylase 2 is found in human gastric cancer. APMIS 113:264–268

    CAS  Google Scholar 

  • St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P (2005) Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959–1961. JAMA 294:557–562

    CAS  Google Scholar 

  • Stafford P, Abdelwahab MG, Preul MC, Rho JM, Scheck AC (2010) The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutr Metab 7:74

    Google Scholar 

  • Stevens AJ, Rucklidge JJ, Kennedy MA (2018) Epigenetics, nutrition and mental health. Is there a relationship? Nutr Neurosci 21:602–613

    CAS  Google Scholar 

  • Stover PJ, Caudill MA (2008) Genetic and epigenetic contributions to human nutrition and health: managing genome–diet interactions. J Am Diet Assoc 108:1480–1487

    Google Scholar 

  • Strakovsky RS, Zhang X, Zhou D, Pan Y-X (2014) The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats. J Nutr Biochem 25:170–176

    CAS  Google Scholar 

  • Strati F, Cavalieri D, Albanese D, De Felice C, Donati C, Hayek J, Jousson O, Leoncini S, Renzi D, Calabrò A (2017) New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome 5:24

    Google Scholar 

  • Strouch MJ, Milam BM, Melstrom LG, McGill JJ, Salabat MR, Ujiki MB, Ding X-Z, Bentrem DJ (2009) The flavonoid apigenin potentiates the growth inhibitory effects of gemcitabine and abrogates gemcitabine resistance in human pancreatic cancer cells. Pancreas 38:409–415

    CAS  Google Scholar 

  • Sturchio J (2006) Comprehensive medicinal chemistry II volume 1: global perspective

  • Subramaniya BR, Srinivasan G, Sadullah SSM, Davis N, Subhadara LBR, Halagowder D, Sivasitambaram ND (2011) Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2. PloS One 6:e18695

  • Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu X-N, Kubo C, Koga Y (2004) Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 558:263–275

    CAS  Google Scholar 

  • Sundaram MK, Ansari MZ, Al Mutery A, Ashraf M, Nasab R, Rai S, Rais N, Hussain A (2018) Genistein induces alterations of epigenetic modulatory signatures in human cervical cancer cells. Anti-Cancer Agents Med Chem (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 18:412–421

    CAS  Google Scholar 

  • Sunkara T, Rawla P, Ofosu A, Gaduputi V (2018) Fecal microbiota transplant–a new frontier in inflammatory bowel disease. J Inflamm Res 11:321

    CAS  Google Scholar 

  • Sutaria D, Grandhi BK, Thakkar A, Wang J, Prabhu S (2012) Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen. Int J Oncol 41:2260–2268

    CAS  Google Scholar 

  • Suter MA, Chen A, Burdine MS, Choudhury M, Harris RA, Lane RH, Friedman JE, Grove KL, Tackett AJ, Aagaard KM (2012) A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J 26:5106–5114

    CAS  Google Scholar 

  • Sutherland BA, Rahman RM, Appleton I (2006) Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. J Nutr Biochem 17:291–306

    CAS  Google Scholar 

  • Suzuki MM, Bird A (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9:465

    CAS  Google Scholar 

  • Szyf M (2014) Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning. Nat Neurosci 17:2

    CAS  Google Scholar 

  • Tabish AM, Poels K, Hoet P, Godderis L (2012) Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells. PLoS ONE 7:e34674

    CAS  Google Scholar 

  • Takeshima M, Ono M, Higuchi T, Chen C, Hara T, Nakano S (2014) Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines. Cancer Sci 105:252–257

    CAS  Google Scholar 

  • Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, Shen Z, Nair V, Yao YJJ (2019) Generating recombinant avian herpesvirus vectors with CRISPR/Cas9 gene editing. 143:e58193

  • Tang WW, Hazen SL (2014) The contributory role of gut microbiota in cardiovascular disease. J Clin Investig 124:4204–4211

    CAS  Google Scholar 

  • Tarantini L, Bonzini M, Apostoli P, Pegoraro V, Bollati V, Marinelli B, Cantone L, Rizzo G, Hou L, Schwartz J (2009) Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect 117:217–222

    CAS  Google Scholar 

  • Tateishi K, Okada Y, Kallin EM, Zhang Y (2009) Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 458:757

    CAS  Google Scholar 

  • Tollefsbol T (2017) Handbook of epigenetics: the new molecular and medical genetics. Academic Press

  • Tosh DN, Fu Q, Callaway CW, McKnight RA, McMillen IC, Ross MG, Lane RH, Desai M (2010) Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth. Am J Physiol-Gastrointest Liver Physiol 299:G1023–G1029

    CAS  Google Scholar 

  • Tripathi YB, Tripathi P, Arjmandi BH (2005) Nutraceuticals and cancer management. Front Biosci 10:1607–1618

    CAS  Google Scholar 

  • Trivedi MS, Hodgson NW, Walker SJ, Trooskens G, Nair V, Deth RC (2015) Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells. Nutr Metab 12:54

    Google Scholar 

  • Uittamo J, Siikala E, Kaihovaara P, Salaspuro M, Rautemaa R (2009) Chronic candidosis and oral cancer in APECED-patients: production of carcinogenic acetaldehyde from glucose and ethanol by Candida albicans. Int J Cancer 124:754–756

    CAS  Google Scholar 

  • Umar M, Adamu M, Sale A, Karaye S (2019) Pharmacognostic and acute toxicity study of Dalbergia Saxatilis stem bark

  • Uygun A, Ozturk K, Demirci H, Oger C, Avci IY, Turker T, Gulsen M (2017) Fecal microbiota transplantation is a rescue treatment modality for refractory ulcerative colitis. Medicine 96(16)

  • Van Dorsten FA, Daykin CA, Mulder TP, Van Duynhoven JP (2006) Metabonomics approach to determine metabolic differences between green tea and black tea consumption. J Agric Food Chem 54:6929–6938

    Google Scholar 

  • Vargas-Mendoza N, Morales-González Á, Madrigal-Santillán EO, Madrigal-Bujaidar E, Álvarez-González I, García-Melo LF, Anguiano-Robledo L, Fregoso-Aguilar T, Morales-Gonzalez JA (2019) Antioxidant and adaptative response mediated by Nrf2 during physical exercise. Antioxidants 8:196

    CAS  Google Scholar 

  • Venigalla M, Gyengesi E, Münch G (2015) Curcumin and apigenin–novel and promising therapeutics against chronic neuroinflammation in Alzheimer’s disease. Neural Regen Res 10:1181

    CAS  Google Scholar 

  • Villeneuve LM, Natarajan R (2010) The role of epigenetics in the pathology of diabetic complications. Am J Physiol-Renal Physiol 299:F14–F25

    CAS  Google Scholar 

  • Vispé S, DeVries L, Créancier L, Besse J, Bréand S, Hobson DJ, Svejstrup JQ, Annereau J-P, Cussac D, Dumontet C (2009) Triptolide is an inhibitor of RNA polymerase I and II–dependent transcription leading predominantly to down-regulation of short-lived mRNA. Mol Cancer Ther 8:2780–2790

    Google Scholar 

  • Wang J, Hodes GE, Zhang H, Zhang S, Zhao W, Golden SA, Bi W, Menard C, Kana V, Leboeuf M (2018a) Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nat Commun 9:477

    Google Scholar 

  • Wang L, Zeng B, Liu Z, Liao Z, Zhong Q, Gu L, Wei H, Fang X (2018b) Green tea polyphenols modulate colonic microbiota diversity and lipid metabolism in high-fat diet treated HFA mice. J Food Sci 83:864–873

    CAS  Google Scholar 

  • Waterland RA, Jirtle RL (2003) Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23:5293–5300

    CAS  Google Scholar 

  • Webster AL, Yan MS-C, Marsden PA (2013) Epigenetics and cardiovascular disease. Can J Cardiol 29:46–57

    Google Scholar 

  • Wei W-Τ, Chen H, Ni Z-L, Liu H-Β, Tong H-F, Fan L, Liu A, Qiu M-Χ, Liu D-L, Guo H-C (2011) Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation. Int J Oncol 39:1381–1390

    CAS  Google Scholar 

  • Wei G, Guan Y, Yin Y, Duan J, Zhou D, Zhu Y, Quan W, Xi M, Wen A (2013) Anti-inflammatory effect of protocatechuic aldehyde on myocardial ischemia/reperfusion injury in vivo and in vitro. Inflammation 36:592–602

    CAS  Google Scholar 

  • Weisbeck A, Jansen RJ (2017) Nutrients and the pancreas: an epigenetic perspective. Nutrients 9:283

    Google Scholar 

  • Winter SE, Bäumler AJ (2014) Dysbiosis in the inflamed intestine: chance favors the prepared microbe. Gut Microbes 5:71–73

    Google Scholar 

  • Winter J, Nyskohus L, Young GP, Hu Y, Conlon MA, Bird AR, Topping DL, Le Leu RK (2011) Inhibition by resistant starch of red meat–induced promutagenic adducts in mouse colon. Cancer Prev Res 4:1920–1928

    CAS  Google Scholar 

  • Wolfram S (2007) Effects of green tea and EGCG on cardiovascular and metabolic health. J Am Coll Nutr 26:373S-388S

    CAS  Google Scholar 

  • Woodworth MH, Carpentieri C, Sitchenko KL, Kraft CS (2017) Challenges in fecal donor selection and screening for fecal microbiota transplantation: a review. Gut Microbes 8:225–237

    Google Scholar 

  • Worthley DL, Whitehall VL, Le Leu RK, Irahara N, Buttenshaw RL, Mallitt K-A, Greco SA, Ramsnes I, Winter J, Hu Y (2011) DNA methylation in the rectal mucosa is associated with crypt proliferation and fecal short-chain fatty acids. Dig Dis Sci 56:387–396

    CAS  Google Scholar 

  • Wren JD, Garner HR (2005) Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes. Biomed Res Int 2005:104–112

    Google Scholar 

  • Wu S, Rhee K-J, Albesiano E, Rabizadeh S, Wu X, Yen H-R, Huso DL, Brancati FL, Wick E, McAllister F (2009) A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med 15:1016

    CAS  Google Scholar 

  • Wu L, Lu Y, Jiao Y, Liu B, Li S, Li Y, Xing F, Chen D, Liu X, Zhao J (2016) Paternal psychological stress reprograms hepatic gluconeogenesis in offspring. Cell Metab 23:735–743

    CAS  Google Scholar 

  • Wu Y, Li RW, Huang H, Fletcher A, Yu L, Pham Q, Yu L, He Q, Wang TTY (2019) Inhibition of tumor growth by dietary indole-3-carbinol in a prostate cancer xenograft model may be associated with disrupted gut microbial interactions. Nutrients 11:467

  • Xia Z-E, Xi J-L, Shi L (2018) 3, 3′-Diindolylmethane ameliorates renal fibrosis through the inhibition of renal fibroblast activation in vivo and in vitro. Ren Fail 40:447–454

    CAS  Google Scholar 

  • Xu G, Xu X, Li Z, He Q, Wu B, Sun S, Chen H (2004) Construction of recombinant pseudorabies virus expressing NS1 protein of Japanese encephalitis (SA14-14-2) virus and its safety and immunogenicity. Vaccine 22:1846–1853

    CAS  Google Scholar 

  • Yamagata K (2018) Do coffee polyphenols have a preventive action on metabolic syndrome associated endothelial dysfunctions? An assessment of the current evidence. Antioxidants 7:26

    Google Scholar 

  • Yang G, Shu X-O, Li H, Chow W-H, Ji B-T, Zhang X, Gao Y-T, Zheng W (2007) Prospective cohort study of green tea consumption and colorectal cancer risk in women. Cancer Epidemiol Prev Biomarkers 16:1219–1223

    CAS  Google Scholar 

  • Yang Y, Wang X, Huycke T, Moore DR, Lightfoot SA, Huycke MM (2013) Colon macrophages polarized by commensal bacteria cause colitis and cancer through the bystander effect. Transl Oncol 6:596

    Google Scholar 

  • Yang L, Palliyaguru DL, Kensler TW (2016) Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane, Seminars in oncology. Elsevier, 43:146–153

  • Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, Gil J, Walsh MJ, Zhou M-M (2010) Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell 38:662–674

    CAS  Google Scholar 

  • Yemitan OK, Adeyemi OO (2017) Mechanistic assessment of the analgesic, anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models. Pharm Biol 55:898–905

    CAS  Google Scholar 

  • Yoshida N, Emoto T, Yamashita T, Watanabe H, Hayashi T, Tabata T, Hoshi N, Hatano N, Ozawa G, Sasaki N (2018) Bacteroides vulgatus and Bacteroides dorei reduce gut microbial lipopolysaccharide production and inhibit atherosclerosis. Circulation 138:2486–2498

    CAS  Google Scholar 

  • Youngson NA, Morris MJ (2013) What obesity research tells us about epigenetic mechanisms. Philos Trans R Soc B: Biol Sci 368:20110337

    Google Scholar 

  • Zhang J, Zhang R, Zhan Z, Li X, Zhou F, Xing A, Jiang C, Chen Y, An L (2017) Beneficial effects of sulforaphane treatment in Alzheimer’s disease may be mediated through reduced HDAC1/3 and increased P75NTR Expression. Front Aging Neurosci 9:121

    CAS  Google Scholar 

  • Zhong J, Karlsson O, Wang G, Li J, Guo Y, Lin X, Zemplenyi M, Sanchez-Guerra M, Trevisi L, Urch B (2017) B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. Proc Natl Acad Sci 114:3503–3508

    CAS  Google Scholar 

  • Zhou L, Foster JA (2015) Psychobiotics and the gut–brain axis: in the pursuit of happiness. Neuropsychiatr Dis Treat 11:715

    Google Scholar 

  • Zinkhan EK, Fu Q, Wang Y, Yu X, Callaway CW, Segar JL, Scholz TD, McKnight RA, Joss-Moore L, Lane RH (2012) Maternal hyperglycemia disrupts histone 3 lysine 36 trimethylation of the IGF-1 gene. J Nutr Metab 930364

  • Zoetendal EG, Cheng B, Koike S, Mackie RI (2004) Molecular microbial ecology of the gastrointestinal tract: from phylogeny to function. Curr Issues Intest Microbiol 5:31–48

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt

    Amr El-Sayed & Mohamed Kamel

  2. Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, 25030, Besançon Cedex, France

    Lotfi Aleya

Authors
  1. Amr El-Sayed
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lotfi Aleya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohamed Kamel
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors (M.K., L.A., and A.E.) contributed, drafted, reviewed, and approved the final version of the manuscript.

Corresponding author

Correspondence to Mohamed Kamel.

Ethics declarations

Ethics approval

Not applicable.

Consent to participate

Not applicable.

Consent for publication

Not applicable.

Conflict of interest

The authors declare no competing interests.

Additional information

Responsible Editor: Philippe Garrigues

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Mohamed Kamel and Amr El-Sayed contributed equally to this work.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

El-Sayed, A., Aleya, L. & Kamel, M. Epigenetics and the role of nutraceuticals in health and disease. Environ Sci Pollut Res 30, 28480–28505 (2023). https://doi.org/10.1007/s11356-023-25236-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11356-023-25236-w

Keywords

Search

Navigation