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Dimethoate induces genotoxicity as a result of oxidative stress: in vivo and in vitro studies

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Abstract

Dimethoate ([O,O-dimethyl S-(N-methylcarbamoylmethyl) phosphorodithioate]) is an organophosphate insecticide and acaricide widely used for agricultural purposes. Genotoxicity refers to the ability of a chemical agent interact directly to DNA or act indirectly leading to DNA damage by affecting spindle apparatus or enzymes involved in DNA replication, thereby causing mutations. Taking into consideration the importance of genotoxicity induced by dimethoate, the purpose of this manuscript was to provide a mini review regarding genotoxicity induced by dimethoate as a result of oxidative stress. The present study was conducted on studies available in MEDLINE, PUBMED, EMBASE, and Google scholar for all kind of articles (all publications published until May, 2020) using the following key words: dimethoate, omethoate, DNA damage, genetic damage, oxidative stress, genotoxicity, mutation, and mutagenicity. The results showed that many studies were published in the scientific literature; the approach was clearly demonstrated in multiple tissues and organs, but few papers were designed in humans. In summary, new studies within the field are important for better understanding the pathobiological events of genotoxicity on human cells, particularly to explain what cells and/or tissues are more sensitive to genotoxic insult induced by dimethoate.

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Funding

DAR and MBV are recipients from CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, grant number #001). DVS and ACMM are repicients from CAPES (Coordenação de Desenvolvimento de Pessoal de Nivel Superior).

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Authors and Affiliations

  1. Institute of Heath and Society, Department of Biosciences, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil

    Marcelo Souza Silva, Daniel Vitor De Souza, Maria Esther Suarez Alpire, Andrea Cristina De Moraes Malinverni, Regina Claudia Barbosa Da Silva, Milena De Barros Viana, Celina Tizuko Fujiyama Oshima & Daniel Araki Ribeiro

Authors
  1. Marcelo Souza Silva
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  2. Daniel Vitor De Souza
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  3. Maria Esther Suarez Alpire
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  4. Andrea Cristina De Moraes Malinverni
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  5. Regina Claudia Barbosa Da Silva
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  6. Milena De Barros Viana
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  7. Celina Tizuko Fujiyama Oshima
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  8. Daniel Araki Ribeiro
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Contributions

Conceptualization: ACMM, RCBS, MBV, CTFO and DAR; data search: MSS, DVS and MESA; formal analysis: ACMM, RCBS, MBV, CTFO and DAR; writing—review and editing: all authors.

Corresponding author

Correspondence to Daniel Araki Ribeiro.

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The authors declare no competing interests.

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Responsible editor: Mohamed M. Abdel-Daim

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Silva, M.S., De Souza, D.V., Alpire, M.E.S. et al. Dimethoate induces genotoxicity as a result of oxidative stress: in vivo and in vitro studies. Environ Sci Pollut Res 28, 43274–43286 (2021). https://doi.org/10.1007/s11356-021-15090-z

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  • DOI: https://doi.org/10.1007/s11356-021-15090-z

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