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Crystal structure and biological activities of water-soluble nickel(II) and copper(II) complexes of a Schiff-base derived from paeonol

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Abstract

Water-soluble Ni(II) and Cu(II) complexes of a flexible Schiff-base ligand have been synthesized, and the Ni(II) complex was characterized by X-ray crystallography. The interactions of the two complexes with calf thymus DNA were investigated by spectroscopic and viscosity measurements in water. The results suggest that the two complexes bind to DNA within the groove. Antioxidant experiments against OH• and O −•2 show that these two complexes have excellent ability to scavenge O −•2 , and the Cu(II) complex exhibits better activity than the Ni(II) complex.

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Acknowledgments

This work is supported by the National Natural Science Foundation of China (20475023) and Gansu NSF (0710RJZA012).

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Authors and Affiliations

  1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, People’s Republic of China

    Dong-Dong Qin, Zheng-Yin Yang, Gao-Fei Qi & Tian-Rong Li

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  1. Dong-Dong Qin
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  2. Zheng-Yin Yang
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Correspondence to Zheng-Yin Yang.

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Qin, DD., Yang, ZY., Qi, GF. et al. Crystal structure and biological activities of water-soluble nickel(II) and copper(II) complexes of a Schiff-base derived from paeonol. Transition Met Chem 34, 499–505 (2009). https://doi.org/10.1007/s11243-009-9222-z

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