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Phosphate-hydrolysis, antioxidant, DNA binding, and nuclease activities promoted by heteroleptic nickel(II) phenolate complexes

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Abstract

Eight heteroleptic nickel(II) complexes of the type [NiL1–4(co-ligand)] 1–8, where L1–4 = N 1,N 2-bis(5-substituted-2-hydroxybenzylidene)-1,2-ethylene/phenylene diimine and co-ligand = 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen), have been synthesized and fully characterized by analytical and spectral methods. The six-coordinated octahedral geometry around the nickel(II) center was inferred from the electronic spectra of the complexes. Cyclic voltammetric studies of the complexes evidenced one-electron irreversible nature of reduction and oxidation process. The observed rate constant (k) values for the hydrolysis of 4-nitrophenylphosphate are in the range of 0.24–2.53 × 10−2 min−1. The obtained room temperature magnetic moment values (2.96–3.31 BM) lies within the range observed for octahedral nickel(II) complexes. Antioxidant studies suggest the considerable radical-scavenging potency of the complexes against DPPH radical. The DNA-binding studies of complexes with calf thymus DNA revealed intercalation with minor-groove mode of binding. The nuclease activity on supercoiled pBR322 DNA revealed the involvement of hydroxyl radical and singlet-oxygen as reactive oxygen species and complexes encourage binding to minor-groove.

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Acknowledgments

The authors are grateful to IIT-M, Chennai, for ESI mass spectral analysis.

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  1. Post-Graduate and Research Department of Chemistry, The New College (Autonomous), Chennai, 600 014, Tamil Nadu, India

    Perumal Gurumoorthy & Aziz Kalilur Rahiman

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  1. Perumal Gurumoorthy
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  2. Aziz Kalilur Rahiman
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Correspondence to Aziz Kalilur Rahiman.

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Gurumoorthy, P., Rahiman, A.K. Phosphate-hydrolysis, antioxidant, DNA binding, and nuclease activities promoted by heteroleptic nickel(II) phenolate complexes. Med Chem Res 24, 2441–2453 (2015). https://doi.org/10.1007/s00044-014-1306-4

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