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Plasminogen deficiency

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Abstract

Plasminogen plays an important role in fibrinolysis as well as wound healing, cell migration, tissue modeling and angiogenesis. Congenital plasminogen deficiency is a rare autosomal recessive disorder that leads to the development of thick, wood-like pseudomembranes on mucosal surfaces, mostly seen in conjunctivas named as ‘‘ligneous conjunctivitis’’. Local conjunctival use of fresh frozen plazma (FFP) in combination with other eye medications such as cyclosporin and artificial tear drops may relieve the symptoms. Topical treatment with plasminogen eye drops is the most promising treatment that is not yet available in Turkey.

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Abbreviations

u-PA:

Urokinase-type plasminogen activator

t-PA:

Tissue-type plasminogen activator

LC:

Ligneous conjunctivitis

LG:

Ligneous gingivitis

FFP:

Fresh frozen plasma

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Authors and Affiliations

  1. Departments of Pediatric Hematology–Oncology, Cerrahpasa Faculty of Medicine, İstanbul University, Armakent B2/8 Konaklar Mah. Şebboy Sok. 4.Levent-İstanbul, 80620, Istanbul, Turkey

    Tiraje Celkan

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Celkan, T. Plasminogen deficiency. J Thromb Thrombolysis 43, 132–138 (2017). https://doi.org/10.1007/s11239-016-1416-6

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