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VI.E.1. Pharmacologic Vitreolysis with Ocriplasmin: Basic Science Studies

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Vitreous

Abstract

Pharmacologic vitreolysis is an important new avenue of ophthalmic therapeutics, representing a paradigm shift from surgical to pharmacologic therapy of vitreoretinal diseases [24, 26, 27]. Ocriplasmin (des-kringle 1-5 plasmin), formerly called microplasmin, is a truncated recombinant form of plasmin. Originally shown to form upon autolytic degradation of plasmin at high pH, it contains the catalytic domain of plasmin but without associated kringles [38]. In ophthalmology, ocriplasmin was initially studied as a possible alternative to plasmin enzyme (desirable because of the difficulties with plasmin preparation) and was found to be a stable, well-characterized, clinical grade product, which was notable given its highly autolytic nature [34].

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Author information

Authors and Affiliations

  1. Department of Retina and Inflammation, Specialized Eye Clinic in Uveitis and Retina, MIOS sa, Lausanne, Switzerland

    Marc D. de Smet MDCM, PhD, FRCSC, FRCOphth, FMH

  2. Department in vivo pharmacology, Thrombogenics nv, Leuven, Belgium

    Bart Jonckx PhD

Authors
  1. Marc D. de Smet MDCM, PhD, FRCSC, FRCOphth, FMH
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  2. Bart Jonckx PhD
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Corresponding author

Correspondence to Marc D. de Smet MDCM, PhD, FRCSC, FRCOphth, FMH .

Editor information

Editors and Affiliations

  1. VMR Institute for Vitreous Macula Retina, Huntington Beach, California, USA

    J. Sebag

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de Smet, M.D., Jonckx, B. (2014). VI.E.1. Pharmacologic Vitreolysis with Ocriplasmin: Basic Science Studies. In: Sebag, J. (eds) Vitreous. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1086-1_52

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  • DOI: https://doi.org/10.1007/978-1-4939-1086-1_52

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