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Copper (I) bromide (CuBr): a highly efficient catalyst for the synthesis of β-enaminone derivatives using ultrasound irradiation under solvent-free conditions

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Abstract

The development of novel, clean, and efficient methods for the preparation of compounds is a major research focus in organic chemistry at the moment. In this context, copper bromide (CuBr) has been utilized as a heterogeneous catalyst for a highly efficient, eco-sustainable, and greener synthesis of β-enaminone derivatives by condensation of 1,3-diketones with various primary amines at room temperature under ultrasound irradiation and solvent-free conditions. The structure of the synthesized compounds was confirmed by 1H, 13C NMR spectroscopy, IR spectroscopy, and elemental analysis. The desired products were obtained in excellent yields (90–98%) within short reaction times (20–50 min).

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Acknowledgements

This work was supported financially by The General Directorate for Scientific Research and Technological Development (DG-RSDT), Algerian Ministry of Scientific Research, Applied Organic Chemistry Laboratory (FNR 2000).

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  1. Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Department of Chemistry, Sciences Faculty, Badji-Mokhtar-Annaba University, Box 1223000, Annaba, Algeria

    Rayenne Redjemia, Abdeslem Bouzina, Yousra Ouafa Bouone, Achraf Mansouri, Rania Bahadi & Malika Berredjem

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  1. Rayenne Redjemia
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Redjemia, R., Bouzina, A., Bouone, Y.O. et al. Copper (I) bromide (CuBr): a highly efficient catalyst for the synthesis of β-enaminone derivatives using ultrasound irradiation under solvent-free conditions. Res Chem Intermed 48, 4947–4962 (2022). https://doi.org/10.1007/s11164-022-04853-z

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