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The impact of Hunner lesion-type interstitial cystitis/bladder pain syndrome on health-related quality of life and the effects of transurethral ablation

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Abstract

Purpose

Interstitial cystitis/bladder pain syndrome (IC/BPS) has a negative impact on quality of life. We compared health-related quality of life (HRQoL) of patients with IC/BPS with patients having other diseases using the EuroQol five-dimension (EQ-5D) and evaluated whether the HRQoL is improved after surgery.

Methods

We compared EQ-5D of patients with Hunner lesion type IC/BPS with patients who had other diseases that cause chronic and severe pain including arthritis and cancer from a cross-sectional analysis of responses to the 2012–2016 Korea National Health and Nutrition Examination Survey. Changes in EQ-5D after transurethral coagulation (TUC) or resection (TUR) were measured in the IC/BPS participants.

Results

Compared to the EQ-5D index of normal population, patients with arthritis, cancer and IC/BPS had − 0.07 (95% CI − 0.07, − 0.06), − 0.01 (95% CI − 0.02, − 0.01), and − 0.21 (95% CI − 0.23, − 0.20) lower scores, respectively. Patients with IC/BPS were 35.9, 9.24, and 9.05 times more likely to have “extreme problem” in pain/discomfort, anxiety/depression, and usual activities EQ-5D domains, respectively, than patients without arthritis/cancer. After TUC or TUR, EQ-5D index was 0.90 in the TUC group and 0.92 in the TUR group.

Conclusion

IC/BPS patients have worse HRQoL than healthy individuals. However, after surgical treatment, HRQoL is restored to a level close to normal.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea

    Kwang Jin Ko & Kyu-Sung Lee

  2. Center for Clinical Epidemiology, Samsung Medical Center, Seoul, Republic of Korea

    Jihyun Lim, Danbee Kang & Juhee Cho

  3. Department of Urology, Armed Forces Pocheon Hospital, Pocheon, Republic of Korea

    Jiwoong Yu

  4. Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea

    Danbee Kang & Juhee Cho

  5. Research Institute for Future Medicine Samsung Medical Center, Seoul, Korea

    Kyu-Sung Lee

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  1. Kwang Jin Ko
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  2. Jihyun Lim
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  3. Jiwoong Yu
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  4. Danbee Kang
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  5. Juhee Cho
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Contributions

KSL and KJK contributed to the study conception and design. Material preparation, data collection, and analysis were performed by KJK, JL, and JY. The first draft of the manuscript was written by KJK and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Kyu-Sung Lee.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by Institutional Review Board of Samsung Medical Center (IRB approval no.,201305127).

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Informed consent was obtained from all individual participants included in the study.

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Ko, K.J., Lim, J., Yu, J. et al. The impact of Hunner lesion-type interstitial cystitis/bladder pain syndrome on health-related quality of life and the effects of transurethral ablation. Qual Life Res 31, 3221–3228 (2022). https://doi.org/10.1007/s11136-022-03183-2

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  • DOI: https://doi.org/10.1007/s11136-022-03183-2

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