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Synthesis and Antiproliferative Activity of 2-Oxo-4-Cyano-1,2-Dihydropyridine-3-Carboxamides

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Pharmaceutical Chemistry Journal Aims and scope

2-Oxo-4-cyano-1,2-dihydropyridine-3-carboxamides were synthesized. Their antiproliferative activity was studied. They were shown to inhibit slightly the growth of cell lines of lung cancer (a more pronounced tendency for lines A549/ATCC, NCI-H522, and HOP-62); colon cancer (more pronounced for line HCC-2998); brain cancer (for line SNB-19), melanoma (for lines UACC-62, SK-MEL-2, and MALME-3M); kidney cancer (for lines A498 and UO-31); and breast cancer (for lines HS 578T and T-47D).

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Authors and Affiliations

  1. Ulyanov Chuvash State University, 15 Moskovskii Prosp, Cheboksary, 428015, Russia

    S. V. Fedoseev & K. V. Lipin

Authors
  1. S. V. Fedoseev
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  2. K. V. Lipin
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Correspondence to S. V. Fedoseev.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 8, pp. 28 – 32, August, 2023.

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Fedoseev, S.V., Lipin, K.V. Synthesis and Antiproliferative Activity of 2-Oxo-4-Cyano-1,2-Dihydropyridine-3-Carboxamides. Pharm Chem J 57, 1197–1201 (2023). https://doi.org/10.1007/s11094-024-03026-z

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