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Antituberculotic Activity of 5-Aryl(Hetaryl)-Methylidene- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones and 5-(2-Chloropropylidene)-2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones

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Pharmaceutical Chemistry Journal Aims and scope

The effect of 5-aryl(hetaryl)methylidene-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones on the viability of laboratory strain M. tuberculosis H37Rv was studied. The minimum inhibitory and bactericidal concentrations and the acute toxicity in mice have been determined. Compounds XIII, XIV, XVII, and XIX had the greatest antituberculotic activity for M. tuberculosis H37Rv, indicating they were promising for further studies aimed at creating effective antituberculotic drugs.

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Acknowledgments

The work was performed in the framework of State Task No. 056-00113-21-00 Development of Diagnostic and Treatment Methods for Leprosy Infection Based on Personalized Medicine Principles.

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Authors and Affiliations

  1. Astrakhan State Medical University, 121 Bakinskaya St., Astrakhan, 414000, Russia

    M. Yu. Yushin, A. V. Lutsenko, L. V. Saroyants, G. N. Genatullina & A. K. Ayupova

  2. Tatishchev Astrakhan State University, 20a Tatishcheva St., Astrakhan, 414056, Russia

    A. G. Tyrkov, L. V. Saroyants & A. K. Ayupova

  3. Astrakhan State Technical University, 16/1 Tatishcheva St., Astrakhan, 414056, Russia

    A. V. Lutsenko

Authors
  1. M. Yu. Yushin
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  2. A. G. Tyrkov
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  3. A. V. Lutsenko
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  4. L. V. Saroyants
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  5. G. N. Genatullina
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  6. A. K. Ayupova
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Corresponding author

Correspondence to A. G. Tyrkov.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 2, pp. 28 – 31, February, 2023.

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Yushin, M.Y., Tyrkov, A.G., Lutsenko, A.V. et al. Antituberculotic Activity of 5-Aryl(Hetaryl)-Methylidene- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones and 5-(2-Chloropropylidene)-2,4,6-Pyrimidine-2,4,6(1H,3H,5H)-Triones. Pharm Chem J 57, 214–217 (2023). https://doi.org/10.1007/s11094-023-02885-2

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