Series of 5-(hetarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)- 2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones were synthesized and tested for antimycobacterial activity against M. lufu and acute toxicity. The 5-(hetarylmethylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones and 5-(2-chloropropylidene)-2,4,6-pyrimidine-2,4,6(1H,3H,5H)-triones were shown to possess low toxicity and antimycobacterial activity of various strengths as compared to dapsone and could be considered promising compounds for further discovery of antimycobacterial drugs.
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Acknowledgments
The work was performed in the framework of a State Task for the Ministry of Health of Russia, Project No. 056-00074-19-00 and was financially supported by the Ministry of Education and Science of the RF, Grant No. 4.9288.2017BCh.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 2, pp. 32 – 35, February, 2020.
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Yushin, M.Y., Tyrkov, A.G., Saroyants, L.V. et al. Synthesis and Antimycobacterial Activity of 5-(Hetarylmethylidene)-2,4,6-Pyrimidine- 2,4,6(1H,3H,5H )-Triones And 5-(2-Chloropropylidene)- 2,4,6-Pyrimidine-2,4,6(1H,3H,5H )-Triones. Pharm Chem J 54, 134–137 (2020). https://doi.org/10.1007/s11094-020-02169-z
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DOI: https://doi.org/10.1007/s11094-020-02169-z