Abstract
Diabetic retinopathy (DR) is a condition that damages the retina in people with diabetes and can lead to vision loss. It can be detected by observing the morphological changes in the fundus image. DR manifests in several types, including, mild non-proliferative DR (MilNPDR), moderate non-proliferative DR (ModNPDR), severe non-proliferative DR (SevNPDR), proliferative DR (PDR), and Severe proliferative DR (SPDR). Diagnosing DR manually is a time-consuming process and requires significant human resources. Computational-based diagnostic framework, on the other hand, may facilitate early detection and timely treatments. Diabetes during pregnancy can lead to a future development of DR in the mother as well as the fetus. The effect of pregnancy on DR is a significant health concern, however, it is unexplored due to the limited number of screening and treatment options. This manuscript aims to give a comprehensive review of DR and its correlation with diabetes during pregnancy. Moreover, it presents the available resources of fundus data sets for DR research and depicts the advanced methodologies for computational aided DR detection. It also highlights the research gaps in DR detection and its classification and therefore opens the possibility of future research on DR during pregnancy.
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Data Availability
Data sharing is not relevant to this article as no data sets were generated or analyzed in the present study.
References
Abbas Q, Fondon I, Sarmiento A, Jiménez S, Alemany P (2017) Automatic recognition of severity level for diagnosis of diabetic retinopathy using deep visual features. Medical & biological engineering & computing 55(11):1959–1974
Abràmoff MD, Lou Y, Erginay A, Clarida W, Amelon R, Folk JC, Niemeijer M (2016) Improved automated detection of diabetic retinopathy on a publicly available dataset through integration of deep learning. Investigative ophthalmology & visual science 57(13):5200–5206
Abràmoff MD, Reinhardt JM, Russell SR, Folk JC, Mahajan VB, Niemeijer M, Quellec G (2010) Automated early detection of diabetic retinopathy. Ophthalmology 117(6):1147–1154
Adal KM, Van Etten PG, Martinez JP, Rouwen KW, Vermeer KA, van Vliet LJ (2017) An automated system for the detection and classification of retinal changes due to red lesions in longitudinal fundus images. IEEE transactions on biomedical engineering 65(6):1382–1390
Adzura S, Muhaya M, Normalina M, Zaleha A, Ezat WS, Tajunisah I (2011) Correlation of serum insulin like growth factor-i with retinopathy in malaysian pregnant diabetics. International journal of ophthalmology 4(1):69
Afzal S, Maqsood M, Nazir F, Khan U, Aadil F, Awan KM, Mehmood I, Song OY (2019) A data augmentation-based framework to handle class imbalance problem for alzheimer’s stage detection. IEEE access 7:115528–115539
Aguiree F, Brown A, Cho NH, Dahlquist G, Dodd S, Dunning T, Hirst M, Hwang C, Magliano D, Patterson C et al (2013) Idf diabetes atlas. SAHMRI
Akram MU, Khalid S, Khan SA (2013) Identification and classification of microaneurysms for early detection of diabetic retinopathy. Pattern recognition 46(1):107–116
Alasil T, Keane PA, Updike JF, Dustin L, Ouyang Y, Walsh AC, Sadda SR (2010) Relationship between optical coherence tomography retinal parameters and visual acuity in diabetic macular edema. Ophthalmology 117(12):2379–2386
Ali-Gombe A, Elyan E, Jayne C (2019) Multiple fake classes gan for data augmentation in face image dataset. In: 2019 International joint conference on neural networks (IJCNN), pp. 1–8. IEEE
Alyoubi WL, Shalash WM, Abulkhair MF (2020) Diabetic retinopathy detection through deep learning techniques: A review. Informatics in Medicine Unlocked 20:100377
Amel F, Mohammed M, Abdelhafid B (2012) Improvement of the hard exudates detection method used for computer-aided diagnosis of diabetic retinopathy. International Journal of Image, Graphics and Signal Processing 4(4):19
Arun C, Taylor R (2008) Influence of pregnancy on long-term progression of retinopathy in patients with type 1 diabetes. Diabetologia 51(6):1041–1045
Arunkumar R, Karthigaikumar P (2017) Multi-retinal disease classification by reduced deep learning features. Neural Computing and Applications 28(2):329–334
Asiri N, Hussain M, Al Adel F, Alzaidi N (2019) Deep learning based computer-aided diagnosis systems for diabetic retinopathy: A survey. Artificial intelligence in medicine 99:101701
Association AD et al (2020) 14. management of diabetes in pregnancy: standards of medical care in diabetes-2020. Diabetes Care 43(Suppl 1):S183–S192
Atwany MZ, Sahyoun AH, Yaqub M (2022) Deep learning techniques for diabetic retinopathy classification: A survey. IEEE Access
Axer-Siegel R, Hod M, Fink-Cohen S, Kramer M, Weinberger D, Schindel B, Yassur Y (1996) Diabetic retinopathy during pregnancy. Ophthalmology 103(11):1815–1819
Bain SC, Klufas MA, Ho A, Matthews DR (2019) Worsening of diabetic retinopathy with rapid improvement in systemic glucose control: a review. Diabetes, Obesity and Metabolism 21(3):454–466
Bandara A, Giragama P (2017) A retinal image enhancement technique for blood vessel segmentation algorithm. In: 2017 IEEE international conference on industrial and information systems (ICIIS), pp. 1–5. IEEE
Basha SS, Prasad KS (2008) Automatic detection of hard exudates in diabetic retinopathy using morphological segmentation and fuzzy logic. International Journal of Computer Science and Network Security 8(12):211–218
Behboudi-Gandevani S, Amiri M, Bidhendi Yarandi R, Ramezani Tehrani F (2019) The impact of diagnostic criteria for gestational diabetes on its prevalence: a systematic review and meta-analysis. Diabetology & metabolic syndrome 11(1):1–18
Bellemo V, Lim ZW, Lim G, Nguyen QD, Xie Y, Yip MY, Hamzah H, Ho J, Lee XQ, Hsu W et al (2019) Artificial intelligence using deep learning to screen for referable and vision-threatening diabetic retinopathy in africa: a clinical validation study. The Lancet Digital Health 1(1):e35–e44
Bernardes R, Nunes S, Pereira I, Torrent T, Rosa A, Coelho D, Cunha-Vaz J (2009) Computer-assisted microaneurysm turnover in the early stages of diabetic retinopathy. Ophthalmologica 223(5):284–291
Best R, Chakravarthy U (1997) Diabetic retinopathy in pregnancy. British journal of ophthalmology 81(3):249–251
Best R, Hayes R, Chakravarthy U, Archer D, Hadden D (1999) Plasma levels of endothelin-1 in diabetic retinopathy in pregnancy. Eye 13(2):179–182
Boeldt D, Bird I (2017) Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia. The Journal of endocrinology 232(1):R27
Bohman L, Winn H, LeRoux P (2011) Surgical decision making for the treatment of intracranial aneurysms. Youmans Neurological Surgery, 6th edn. Elsevier, Philadelphia
Boone MI, Farber ME, Jovanovic-Peterson L, Peterson CM (1989) Increased retinal vascular tortuosi ityn gestational diabetes mellitus. Ophthalmology 96(2):251–254
Bourry J, Courteville H, Ramdane N, Drumez E, Duhamel A, Subtil D, Deruelle P, Vambergue A (2021) Progression of diabetic retinopathy and predictors of its development and progression during pregnancy in patients with type 1 diabetes: a report of 499 pregnancies. Diabetes Care 44(1):181–187
Budai A, Bock R, Maier A, Hornegger J, Michelson G (2013) Robust vessel segmentation in fundus images. Int J Biomed Imaging 2013
Bui T, Maneerat N, Watchareeruetai U (2017) Detection of cotton wool for diabetic retinopathy analysis using neural network. In: 2017 IEEE 10th International Workshop on Computational Intelligence and Applications (IWCIA), pp. 203–206. IEEE
Chakravarthy SN, Singhal H, RP NY (2019) Dr-net: A stacked convolutional classifier framework for detection of diabetic retinopathy. In: 2019 International Joint Conference on Neural Networks (IJCNN), pp. 1–7. IEEE
Chandrasekaran PR, Madanagopalan V, Narayanan R (2021) Diabetic retinopathy in pregnancy-a review. Indian Journal of Ophthalmology 69(11):3015
Choi Y, Uh Y, Yoo J, Ha JW (2020) Stargan v2: Diverse image synthesis for multiple domains. In: Proceedings of the IEEE/CVF conference on computer vision and pattern recognition, pp. 8188–8197
Chu A, Squirrell D, Phillips AM, Vaghefi E (2020) Essentials of a robust deep learning system for diabetic retinopathy screening: a systematic literature review. J Ophthalmol 2020
Chudzik P, Majumdar S, Calivá F, Al-Diri B, Hunter A (2018) Microaneurysm detection using fully convolutional neural networks. Computer methods and programs in biomedicine 158:185–192
Das UN (2013) Lipoxins, resolvins, and protectins in the prevention and treatment of diabetic macular edema and retinopathy. Nutrition 29(1):1–7
Davoudi S, Papavasileiou E, Roohipoor R, Cho H, Kudrimoti S, Hancock H, Hoadley S, Andreoli C, Husain D, James M et al (2016) Optical coherence tomography characteristics of macular edema and hard exudates and their association with lipid serum levels in type 2 diabetes. Retina (Philadelphia, Pa.) 36(9):1622
De Fauw J, Keane P, Tomasev N, Visentin D, van den Driessche G, Johnson M, Hughes CO, Chu C, Ledsam J, Back T et al (2016) Automated analysis of retinal imaging using machine learning techniques for computer vision. F1000Research 5
Decenciere E, Cazuguel G, Zhang X, Thibault G, Klein JC, Meyer F, Marcotegui B, Quellec G, Lamard M, Danno R et al (2013) Teleophta: Machine learning and image processing methods for teleophthalmology. Irbm 34(2):196–203
Decencière E, Zhang X, Cazuguel G, Lay B, Cochener B, Trone C, Gain P, Ordonez R, Massin P, Erginay A et al (2014) Feedback on a publicly distributed image database: the messidor database. Image Analysis & Stereology 33(3):231–234
Dibble C, Kochenour N, Worley R, Tyler F, Swartz M (1982) Effect of pregnancy on diabetic retinopathy. Obstetrics and gynecology 59(6):699–704
Dosovitskiy A, Beyer L, Kolesnikov A, Weissenborn D, Zhai X, Unterthiner T, Dehghani M, Minderer M, Heigold G, Gelly S et al (2020) An image is worth 16x16 words: Transformers for image recognition at scale. arXiv preprint arXiv:2010.11929
Egan AM, McVicker L, Heerey A, Carmody L, Harney F, Dunne FP (2015) Diabetic retinopathy in pregnancy: a population-based study of women with pregestational diabetes. Journal of Diabetes Research 2015
El Annan J, Carvounis PE (2014) Current management of vitreous hemorrhage due to proliferative diabetic retinopathy. International ophthalmology clinics 54(2):141
Errera MH, Kohly RP, da Cruz L (2013) Pregnancy-associated retinal diseases and their management. Survey of Ophthalmology 58(2):127–142
Fan Z, Lu J, Wei C, Huang H, Cai X, Chen X (2018) A hierarchical image matting model for blood vessel segmentation in fundus images. IEEE Transactions on Image Processing 28(5):2367–2377
Farnell DJ, Hatfield FN, Knox P, Reakes M, Spencer S, Parry D, Harding SP (2008) Enhancement of blood vessels in digital fundus photographs via the application of multiscale line operators. Journal of the Franklin institute 345(7):748–765
Ferris FL III, Patz A (1984) Macular edema: a complication of diabetic retinopathy. Survey of Ophthalmology 28:452–461
Fink W, Tarbell M (2015) Smart ophthalmics: a smart service platform for tele-ophthalmology. Investigative Ophthalmology & Visual Science 56(7):4110–4110
Flaxel CJ, Edwards AR, Aiello LP, Arrigg PG, Beck RW, Bressler NM, Bressler SB, Ferris FL III, Gupta SK, Haller JA et al (2010) Factors associated with visual acuity outcomes after vitrectomy for diabetic macular edema: diabetic retinopathy clinical research network. Retina 30(9):1488–1495
Fraz MM, Remagnino P, Hoppe A, Uyyanonvara B, Rudnicka AR, Owen CG, Barman SA (2012) An ensemble classification-based approach applied to retinal blood vessel segmentation. IEEE Transactions on Biomedical Engineering 59(9):2538–2548. https://doi.org/10.1109/TBME.2012.2205687
Ganesan K, Martis RJ, Acharya UR, Chua CK, Min LC, Ng E, Laude A (2014) Computer-aided diabetic retinopathy detection using trace transforms on digital fundus images. Medical & biological engineering & computing 52(8):663–672
Gao Z, Li J, Guo J, Chen Y, Yi Z, Zhong J (2018) Diagnosis of diabetic retinopathy using deep neural networks. IEEE Access 7:3360–3370
Gegundez-Arias ME, Marin D, Ponte B, Alvarez F, Garrido J, Ortega C, Vasallo MJ, Bravo JM (2017) A tool for automated diabetic retinopathy pre-screening based on retinal image computer analysis. Computers in biology and medicine 88:100–109
Gouliopoulos N, Kalogeropoulos C, Lavaris A, Rouvas A, Asproudis I, Garmpi A, Damaskos C, Garmpis N, Kostakis A, Moschos M (2018) Association of serum inflammatory markers and diabetic retinopathy: a review of literature. Eur Rev Med Pharmacol Sci 22(21):7113–7128
Govind D, Jen KY, Matsukuma K, Gao G, Olson KA, Gui D, Wilding G, Border SP, Sarder P et al (2020) Improving the accuracy of gastrointestinal neuroendocrine tumor grading with deep learning. Scientific reports 10(1):1–12
Grossniklaus HE, Green WR (2004) Choroidal neovascularization. American journal of ophthalmology 137(3):496–503
Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J et al (2016) Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. Jama 316(22):2402–2410
Guo Y, Peng Y (2020) Bscn: bidirectional symmetric cascade network for retinal vessel segmentation. BMC medical imaging 20:1–22
Haddock LJ, Kim DY, Mukai S (2013) Simple, inexpensive technique for high-quality smartphone fundus photography in human and animal eyes. Journal of Ophthalmology 2013
He A, Li T, Li N, Wang K, Fu H (2020) Cabnet: category attention block for imbalanced diabetic retinopathy grading. IEEE Transactions on Medical Imaging 40(1):143–153
Hemanth DJ, Anitha J, Son LH, Mittal M (2018) Diabetic retinopathy diagnosis from retinal images using modified hopfield neural network. Journal of medical systems 42(12):1–6
Holmberg OG, Köhler ND, Martins T, Siedlecki J, Herold T, Keidel L, Asani B, Schiefelbein J, Priglinger S, Kortuem KU et al (2020) Self-supervised retinal thickness prediction enables deep learning from unlabelled data to boost classification of diabetic retinopathy. Nature Machine Intelligence 2(11):719–726
Hoover A, Kouznetsova V, Goldbaum M (2000) Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response. IEEE Transactions on Medical imaging 19(3):203–210
Hossain NI, Reza S (2017) Blood vessel detection from fundus image using markov random field based image segmentation. In: 2017 4th International Conference on Advances in Electrical Engineering (ICAEE), pp. 123–127. IEEE
Hua CH, Huynh-The T, Lee S (2019) Retinal vessel segmentation using round-wise features aggregation on bracket-shaped convolutional neural networks. In: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 36–39. IEEE
Huang S, Li J, Xiao Y, Shen N, Xu T (2022) Rtnet: Relation transformer network for diabetic retinopathy multi-lesion segmentation. IEEE Transactions on Medical Imaging
Immonen I, Loukovaara S, Koistinen R, Kaaja R (2004) Inflammatory markers and retinopathy in pregnancies complicated by diabetes. Investigative Ophthalmology & Visual Science 45(13):4168–4168
Ioannides A, Georgakarakos ND, Elaroud I, Andreou P (2011) Isolated cotton-wool spots of unknown etiology: management and sequential spectral domain optical coherence tomography documentation. Clinical Ophthalmology (Auckland, NZ) 5:1431
Ishtiaq U, Abdul Kareem S, Abdullah ERMF, Mujtaba G, Jahangir R, Ghafoor HY (2020) Diabetic retinopathy detection through artificial intelligent techniques: a review and open issues. Multimedia Tools and Applications 79(21):15209–15252
Kaggle (2015) EYEPACS 2015 diabetic retinopathy detection eyepacs dataset. Kaggle, San Francisco, CA, USA. https://www.kaggle.com/c/aptos2019-blindness-detection
Kaggle (2019) APTOS 2019 blindness detection. https://www.kaggle.com/c/aptos2019-blindness-detection
Kamran SA, Hossain KF, Tavakkoli A, Zuckerbrod SL (2021) Attention2angiogan: Synthesizing fluorescein angiography from retinal fundus images using generative adversarial networks. In: 2020 25th International Conference on Pattern Recognition (ICPR), pp. 9122–9129. IEEE
Kamran SA, Hossain KF, Tavakkoli A, Zuckerbrod SL, Baker SA (2021) Vtgan: Semi-supervised retinal image synthesis and disease prediction using vision transformers. In: Proceedings of the IEEE/CVF International Conference on Computer Vision, pp. 3235–3245
Kauppi T, Kalesnykiene V, Kamarainen JK, Lensu L, Sorri I, Raninen A, Voutilainen R, Uusitalo H, Kälviäinen H, Pietilä J (2007) The diaretdb1 diabetic retinopathy database and evaluation protocol. In: BMVC, vol. 1, p. 10. Citeseer
Kauppi T, Kalesnykiene V, Kamarainen JK, Lensu L, Sorri I, Uusitalo H, Kälviäinen H, Pietilä J (2006) Diaretdb0: Evaluation database and methodology for diabetic retinopathy algorithms. Machine Vision and Pattern Recognition Research Group, Lappeenranta University of Technology, Finland 73:1–17
Khalaf N, Helmy H, Fahmy I, Abd El Hamid M, Moemen L et al (2017) Role of angiopoietins and tie-2 in diabetic retinopathy. Electronic Physician 9(8):5031
Kitzmiller JL, Block JM, Brown FM, Catalano PM, Conway DL, Coustan DR, Gunderson EP, Herman WH, Hoffman LD, Inturrisi M et al (2008) Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care. Diabetes care 31(5):1060–1079
Klein BE, Moss SE, Klein R (1990) Effect of pregnancy on progression of diabetic retinopathy. Diabetes care 13(1):34–40
Krause J, Gulshan V, Rahimy E, Karth P, Widner K, Corrado GS, Peng L, Webster DR (2018) Grader variability and the importance of reference standards for evaluating machine learning models for diabetic retinopathy. Ophthalmology 125(8):1264–1272
Kumar NS, Karthikeyan BR (2021) Diabetic retinopathy detection using cnn, transformer and mlp based architectures. In: 2021 International Symposium on Intelligent Signal Processing and Communication Systems (ISPACS), pp. 1–2. IEEE
Kusakunniran W, Wu Q, Ritthipravat P, Zhang J (2018) Hard exudates segmentation based on learned initial seeds and iterative graph cut. Computer methods and programs in biomedicine 158:173–183
Lauszus F, Klebe JG, Bek T (2000) Diabetic retinopathy in pregnancy during tight metabolic control. Acta obstetricia et gynecologica Scandinavica 79(5):367–370
Lee J, Lee EJ (2022) Self-supervised pre-training improves fundus image classification for diabetic retinopathy. In: Real-Time Image Processing and Deep Learning 2022, vol. 12102, pp. 193–198. SPIE
Leopold HA, Orchard J, Zelek JS, Lakshminarayanan V (2019) Pixelbnn: augmenting the pixelcnn with batch normalization and the presentation of a fast architecture for retinal vessel segmentation. Journal of Imaging 5(2):26
Levin AV (2010) Retinal hemorrhage in abusive head trauma. Pediatrics 126(5):961–970
Li LJ, Kramer M, Tapp RJ, Man RE, Lek N, Cai S, Yap F, Gluckman P, Tan KH, Chong YS et al (2017) Gestational diabetes mellitus and retinal microvasculature. BMC ophthalmology 17(1):1–7
Li T, Gao Y, Wang K, Guo S, Liu H, Kang H (2019) Diagnostic assessment of deep learning algorithms for diabetic retinopathy screening. Information Sciences 501:511–522
Li X, Hu X, Yu L, Zhu L, Fu CW, Heng PA (2019) Canet: cross-disease attention network for joint diabetic retinopathy and diabetic macular edema grading. IEEE transactions on medical imaging 39(5):1483–1493
Li X, Pang T, Xiong B, Liu W, Liang P, Wang T (2017) Convolutional neural networks based transfer learning for diabetic retinopathy fundus image classification. In: 2017 10th international congress on image and signal processing, biomedical engineering and informatics (CISP-BMEI), pp. 1–11. IEEE
Li X, Shen L, Shen M, Tan F, Qiu CS (2019) Deep learning based early stage diabetic retinopathy detection using optical coherence tomography. Neurocomputing 369:134–144
Li Z, Wu C, Olayiwola JN, Hilaire DS, Huang JJ (2012) Telemedicine-based digital retinal imaging vs standard ophthalmologic evaluation for the assessment of diabetic retinopathy. Connecticut Medicine 76(2)
Lin J, Cai Q, Lin M (2021) Multi-label classification of fundus images with graph convolutional network and self-supervised learning. IEEE Signal Processing Letters 28:454–458
Liu YP, Li Z, Xu C, Li J, Liang R (2019) Referable diabetic retinopathy identification from eye fundus images with weighted path for convolutional neural network. Artificial intelligence in medicine 99:101694
Lord RK, Shah VA, San Filippo AN, Krishna R (2010) Novel uses of smartphones in ophthalmology. Ophthalmology 117(6):1274–1274
Loukovaara S, Immonen I, Koistinen R, Hiilesmaa V, Kaaja R (2005) Inflammatory markers and retinopathy in pregnancies complicated with type i diabetes. Eye 19(4):422–430
Loukovaara S, Immonen I, Teramo KA, Kaaja R (2003) Progression of retinopathy during pregnancy in type 1 diabetic women treated with insulin lispro. Diabetes care 26(4):1193–1198
Loukovaara S, Immonen IR, Loukovaara MJ, Koistinen R, Kaaja RJ (2007) Glycodelin: a novel serum anti-inflammatory marker in type 1 diabetic retinopathy during pregnancy. Acta Ophthalmologica Scandinavica 85(1):46–49
Lu CD, Kraus MF, Potsaid B, Liu JJ, Choi W, Jayaraman V, Cable AE, Hornegger J, Duker JS, Fujimoto JG (2014) Handheld ultrahigh speed swept source optical coherence tomography instrument using a mems scanning mirror. Biomedical optics express 5(1):293–311
Luo Y, Pan J, Fan S, Du Z, Zhang G (2020) Retinal image classification by self-supervised fuzzy clustering network. IEEE Access 8:92352–92362
Makwana T, Takkar B, Venkatesh P, Sharma JB, Gupta Y, Chawla R, Vohra R, Kriplani A, Tandon N (2018) Prevalence, progression, and outcomes of diabetic retinopathy during pregnancy in indian scenario. Indian journal of ophthalmology 66(4):541
Mallika P, Tan A, Aziz S, Asok T, Alwi SS, Intan G (2010) Diabetic retinopathy and the effect of pregnancy. Malaysian family physician: the official journal of the Academy of Family Physicians of Malaysia 5(1):2
Mane VM, Kawadiwale RB, Jadhav D (2015) Detection of red lesions in diabetic retinopathy affected fundus images. In: 2015 IEEE International Advance Computing Conference (IACC), pp. 56–60. IEEE
Micheletti JM, Hendrick AM, Khan FN, Ziemer DC, Pasquel FJ (2016) Current and next generation portable screening devices for diabetic retinopathy. Journal of diabetes science and technology 10(2):295–300
Mo J, Zhang L (2017) Multi-level deep supervised networks for retinal vessel segmentation. International journal of computer assisted radiology and surgery 12(12):2181–2193
Morrison JL, Hodgson LA, Lim LL, Al-Qureshi S (2016) Diabetic retinopathy in pregnancy: a review. Clinical & experimental ophthalmology 44(4):321–334
Referral system for hard exudates in eye fundus (2015) Naqvi, S.A.G., Zafar, M.F., ul Haq, I. Computers in biology and medicine 64:217–235
Niemeijer M, Van Ginneken B, Cree MJ, Mizutani A, Quellec G, Sánchez CI, Zhang B, Hornero R, Lamard M, Muramatsu C et al (2009) Retinopathy online challenge: automatic detection of microaneurysms in digital color fundus photographs. IEEE transactions on medical imaging 29(1):185–195
Nijalingappa P, Sandeep B (2015) Machine learning approach for the identification of diabetes retinopathy and its stages. In: 2015 International Conference on Applied and Theoretical Computing and Communication Technology (ICATCCT), pp. 653–658. IEEE
Oke J, Stratton I, Aldington S, Stevens R, Scanlon PH (2016) The use of statistical methodology to determine the accuracy of grading within a diabetic retinopathy screening programme. Diabetic Medicine 33(7):896–903
Pao SI, Lin HZ, Chien KH, Tai MC, Chen JT, Lin GM (2020) Detection of diabetic retinopathy using bichannel convolutional neural network. Journal of Ophthalmology 2020
Papadopoulos A, Topouzis F, Delopoulos A (2021) An interpretable multiple-instance approach for the detection of referable diabetic retinopathy in fundus images. Scientific Reports 11(1):1–15
Pappot N, Do NC, Vestgaard M, Ásbjörnsdóttir B, Hajari JN, Lund-Andersen H, Holmager P, Damm P, Ringholm L, Mathiesen ER (2022) Prevalence and severity of diabetic retinopathy in pregnant women with diabetes-time to individualize photo screening frequency. Diabetic Medicine :e14819
Pasquel FJ, Hendrick AM, Ryan M, Cason E, Ali MK, Narayan KV (2016) Cost-effectiveness of different diabetic retinopathy screening modalities. Journal of diabetes science and technology 10(2):301–307
Patwari MB, Manza RR, Rajput YM, Rathod DD, Saswade M, Deshpande N (2016) Classification and calculation of retinal blood vessels parameters. In: IEEE’s International Conferences For Convergence Of Technology, Pune, India, pp. 1–6
Prentasic P, Loncaric S (2014) Weighted ensemble based automatic detection of exudates in fundus photographs. In: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 138–141. IEEE
Prentašić P, Lončarić S, Vatavuk Z, Benčić G, Subašić M, Petković T, Dujmović L, Malenica-Ravlić M, Budimlija N, Tadić R (2013) Diabetic retinopathy image database (dridb): a new database for diabetic retinopathy screening programs research. In: 2013 8th International Symposium on Image and Signal Processing and Analysis (ISPA), pp. 711–716. IEEE
Quellec G, Charrière K, Boudi Y, Cochener B, Lamard M (2017) Deep image mining for diabetic retinopathy screening. Medical image analysis 39:178–193
Qummar S, Khan FG, Shah S, Khan A, Shamshirband S, Rehman ZU, Khan IA, Jadoon W (2019) A deep learning ensemble approach for diabetic retinopathy detection. Ieee Access 7:150530–150539
Raman P, Livingstone BI (2018) Advanced diabetic eye disease in pregnancy. Journal of Clinical Gynecology and Obstetrics 7(3–4):72–75
Ramos JMA, Perdómo O, González FA (2022) Deep semi-supervised and self-supervised learning for diabetic retinopathy detection. arXiv preprint arXiv:2208.02408
Rasmussen K, Laugesen C, Ringholm L, Vestgaard M, Damm P, Mathiesen E (2010) Progression of diabetic retinopathy during pregnancy in women with type 2 diabetes. Diabetologia 53(6):1076–1083
Rochac JFR, Zhang, N, Thompson L, Oladunni T (2019) A data augmentation-assisted deep learning model for high dimensional and highly imbalanced hyperspectral imaging data. In: 2019 9th International Conference on Information Science and Technology (ICIST), pp. 362–367. IEEE
Rosenn B, Miodovnik M, Kranias G, Khoury J, Combs CA, Mimouni F, Siddiqi TA, Lipman MJ (1992) Progression of diabetic retinopathy in pregnancy: association with hypertension in pregnancy. American journal of obstetrics and gynecology 166(4):1214–1218
Sahu S, Singh AK, Ghrera S, Elhoseny M et al (2019) An approach for de-noising and contrast enhancement of retinal fundus image using clahe. Optics & Laser Technology 110:87–98
Sayres R, Taly A, Rahimy E, Blumer K, Coz D, Hammel N, Krause J, Narayanaswamy A, Rastegar Z, Wu D et al (2019) Using a deep learning algorithm and integrated gradients explanation to assist grading for diabetic retinopathy. Ophthalmology 126(4):552–564
Sixt L, Wild B, Landgraf T (2018) Rendergan: Generating realistic labeled data. Frontiers in Robotics and AI 5:66
Srinivasan V, Strodthoff N, Ma J, Binder A, Müller KR, Samek W (2021) On the robustness of pretraining and self-supervision for a deep learning-based analysis of diabetic retinopathy. arXiv preprint arXiv:2106.13497
Staal J, Abràmoff MD, Niemeijer M, Viergever MA, Van Ginneken B (2004) Ridge-based vessel segmentation in color images of the retina. IEEE transactions on medical imaging 23(4):501–509
Sugimoto M, Sampa K, Tsukitome H, Kato K, Matsubara H, Asami S, Sekimoto K, Kitano S, Yoshida S, Takamura Y et al (2021) Trends in the prevalence and progression of diabetic retinopathy associated with hyperglycemic disorders during pregnancy in japan. Journal of clinical medicine 11(1):165
Sun R, Li Y, Zhang T, Mao Z, Wu F, Zhang Y (2021) Lesion-aware transformers for diabetic retinopathy grading. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 10938–10947
Sun Y (2019) The neural network of one-dimensional convolution-an example of the diagnosis of diabetic retinopathy. IEEE Access 7:69657–69666
Taherkhani A, Cosma G, McGinnity TM (2020) Adaboost-cnn: An adaptive boosting algorithm for convolutional neural networks to classify multi-class imbalanced datasets using transfer learning. Neurocomputing 404:351–366
Takahashi H, Tampo H, Arai Y, Inoue Y, Kawashima H (2017) Applying artificial intelligence to disease staging: Deep learning for improved staging of diabetic retinopathy. PloS one 12(6):e0179790
Tan JH, Fujita H, Sivaprasad S, Bhandary SV, Rao AK, Chua KC, Acharya UR (2017) Automated segmentation of exudates, haemorrhages, microaneurysms using single convolutional neural network. Information sciences 420:66–76
Temple R, Aldridge V, Sampson M, Greenwood R, Heyburn P, Glenn A (2001) Impact of pregnancy on the progression of diabetic retinopathy in type 1 diabetes. Diabetic Medicine 18(7):573–577
Ting DSW, Cheung CYL, Lim G, Tan GSW, Quang ND, Gan A, Hamzah H, Garcia-Franco R, San Yeo IY, Lee SY et al (2017) Development and validation of a deep learning system for diabetic retinopathy and related eye diseases using retinal images from multiethnic populations with diabetes. Jama 318(22):2211–2223
Tjandrasa H, Putra RE, Wijaya AY, Arieshanti I (2013) Classification of non-proliferative diabetic retinopathy based on hard exudates using soft margin svm. In: 2013 IEEE International Conference on Control System, Computing and Engineering, pp. 376–380. IEEE
Tranos PG, Wickremasinghe SS, Stangos NT, Topouzis F, Tsinopoulos I, Pavesio CE (2004) Macular edema. Survey of ophthalmology 49(5):470–490
Tymchenko B, Marchenko, P, Spodarets D (2020) Deep learning approach to diabetic retinopathy detection. arXiv preprint arXiv:2003.02261
Vestgaard M, Ringholm L, Laugesen C, Rasmussen K, Damm P, Mathiesen E (2010) Pregnancy-induced sight-threatening diabetic retinopathy in women with type 1 diabetes. Diabetic Medicine 27(4):431–435
Wang Y, Yu M, Hu B, Jin X, Li Y, Zhang X, Zhang Y, Gong D, Wu C, Zhang B et al (2021) Deep learning-based detection and stage grading for optimising diagnosis of diabetic retinopathy. Diabetes/Metabolism Research and Reviews 37(4):e3445
Wilkinson CP, Ferris FL III, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110(9):1677–1682
Wu J, Hu R, Xiao Z, Chen J, Liu J (2021) Vision transformer-based recognition of diabetic retinopathy grade. Medical Physics 48(12):7850–7863
Wu L, Fernandez-Loaiza P, Sauma J, Hernandez-Bogantes E, Masis M (2013) Classification of diabetic retinopathy and diabetic macular edema. World journal of diabetes 4(6):290
Yu S, Ma K, Bi Q, Bian C, Ning M, He N, Li Y, Liu H, Zheng Y (2021) Mil-vt: Multiple instance learning enhanced vision transformer for fundus image classification. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 45–54. Springer
Yu S, Zhang S, Wang B, Dun H, Xu L, Huang X, Shi E, Feng X (2021) Generative adversarial network based data augmentation to improve cervical cell classification model. Math. Biosci. Eng 18:1740–1752
Zeghlache R, Conze PH, Daho MEH, Tadayoni R, Massin P, Cochener B, Quellec G, Lamard M (2022) Detection of diabetic retinopathy using longitudinal self-supervised learning. arXiv preprint arXiv:2209.00915
Zeng X, Chen H, Luo Y, Ye W (2019) Automated diabetic retinopathy detection based on binocular siamese-like convolutional neural network. IEEE Access 7:30744–30753
Zhang W, Zhong J, Yang S, Gao Z, Hu J, Chen Y, Yi Z (2019) Automated identification and grading system of diabetic retinopathy using deep neural networks. Knowledge-Based Systems 175:12–25
Zhang X, Chutatape O (2005) A svm approach for detection of hemorrhages in background diabetic retinopathy. In: Proceedings. 2005 IEEE International Joint Conference on Neural Networks, 2005., vol. 4, pp. 2435–2440. IEEE
Zhou Y, He X, Huang L, Liu L, Zhu F, Cui S, Shao L (2019) Collaborative learning of semi-supervised segmentation and classification for medical images. In: Proceedings of the IEEE/CVF conference on computer vision and pattern recognition, pp. 2079–2088
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Ghosh, D., Chowdhury, K. & Muhuri, S. Finding correlation between diabetic retinopathy and diabetes during pregnancy based on computer-aided diagnosis: a review. Multimed Tools Appl 83, 27037–27065 (2024). https://doi.org/10.1007/s11042-023-16449-9
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DOI: https://doi.org/10.1007/s11042-023-16449-9