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The application of MARCO for immune regulation and treatment

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Abstract

Macrophage receptor with collagen structure (MARCO) is a member of scavenger receptor class A (SR-A) and shares structural and functional similarities with SR-A1. In recent years, many studies have shown that MARCO can trigger an immune response and has therapeutic potential as a target for immunotherapy. Studies have shown that alterations in MARCO expression following pathogen infection cause changes in the functions of innate and adaptive immune cells, including macrophages, dendritic cells, B cells, and T cells, affecting the body’s immune response to invading pathogens; thus, MARCO plays a crucial role in triggering the immune response, bridging innate and adaptive immunity, and eliminating pathogens. This paper is a comprehensive summary of the recent research on MARCO. This review focuses on the multiple functions of MARCO, including adhesion, migration, phagocytosis, and cytokine secretion with special emphasis on the complex interactions between MARCO and various types of cells involved in the immune response, as well as possible immune-related mechanisms. In summary, in this review, we discuss the structure and function of MARCO and its role in the immune response and highlight the therapeutic potential of MARCO as a target for immunotherapy. We hope that this review provides a theoretical basis for future research on MARCO.

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Abbreviations

MARCO:

Macrophage Receptor with Collagen Structure

SR-A:

scavenger receptor class A

PAMPs:

pathogen-associated molecular patterns

PRRs:

pattern recognition receptors

TLRs:

Toll-like receptors

SRs:

scavenger receptors

SRCR:

scavenger receptor cysteine rich

TNFα:

tumor necrosis factor alpha

IFN-γ:

interferon-gamma

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Funding

This work was supported by the National Key Research and Development Program of China (grant numbers [2022YFC2704400]).

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Authors and Affiliations

  1. Department of Histology and Embryology, Hebei Medical University, No. 361, Zhongshan East Road, Chang’an District, Shijiazhuang, 050017, China

    Guiyuan Zhou & Suxia Shao

  2. Shijiazhuang Vocational College of City Economy, No. 12, Wenming Road, Economic and Technological Development Zone, Shijiazhuang, 050017, China

    Lei Zhang

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  1. Guiyuan Zhou
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  2. Lei Zhang
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  3. Suxia Shao
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Contributions

Conceptualization: G.Z. and S.S.; Investigation: G.Z.; Writing - Original Draft: G.Z.; Visualization: G.Z.; Resources: L.Z.; Project administration: L.Z.; Funding acquisition: L.Z.; Writing - Review & Editing: S.S.; Supervision: S.S. All authors read and approved the final manuscript.

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Correspondence to Lei Zhang or Suxia Shao.

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Zhou, G., Zhang, L. & Shao, S. The application of MARCO for immune regulation and treatment. Mol Biol Rep 51, 246 (2024). https://doi.org/10.1007/s11033-023-09201-x

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