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Alzheimer’s disease, aging, and cannabidiol treatment: a promising path to promote brain health and delay aging

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Abstract

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss, neurodegeneration, and cognitive decline. Aging is one of the risk factors for AD. Although the mechanisms underlying aging and the incidence rate of AD are unclear, aging and AD share some hallmarks, such as oxidative stress and chronic inflammation. Cannabidiol (CBD), the major non-psychoactive phytocannabinoid extracted from Cannabis sativa, has recently emerged as a potential candidate for delaying aging and a valuable therapeutic tool for the treatment of aging-related neurodegenerative diseases due to its antioxidant and anti-inflammation properties. This article reviews the relevant literature on AD, CBD treatment for AD, cellular senescence, aging, and CBD treatment for aging in recent years. By analyzing these published data, we attempt to explore the complex correlation between cellular senescence, aging, and Alzheimer’s disease, clarify the positive feedback effect between the senescence of neurocytes and Alzheimer’s disease, and summarize the role and possible molecular mechanisms of CBD in preventing aging and treating AD. These data may provide new ideas on how to effectively prevent and delay aging, and develop effective treatment strategies for age-related diseases such as Alzheimer’s disease.

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Funding

This work was supported by the Doctoral Research Startup Funding from Qingdao Huanghai University (2021boshi01) and the Shandong Provincial Natural Science Foundation (ZR2022MC192).

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  1. Department of Basic Medicine, School of Medicine, Qingdao Huanghai University, Qingdao, 266427, China

    Yanying Liu

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YL conceptualized, wrote, and edited the manuscript.

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Liu, Y. Alzheimer’s disease, aging, and cannabidiol treatment: a promising path to promote brain health and delay aging. Mol Biol Rep 51, 121 (2024). https://doi.org/10.1007/s11033-023-09162-1

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