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ANRIL, H19 and TUG1: a review about critical long non-coding RNAs in cardiovascular diseases

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Abstract

Cardiovascular diseases are the leading cause of death worldwide. They are non-transmissible diseases that affect the cardiovascular system and have different etiologies such as smoking, lipid disorders, diabetes, stress, sedentary lifestyle and genetic factors. To date, lncRNAs have been associated with increased susceptibility to the development of cardiovascular diseases such as hypertension, acute myocardial infarction, stroke, angina and heart failure. In this way, lncRNAs are becoming a very promising point for the prevention and diagnosis of cardiovascular diseases. Therefore, this review highlights the most important and recent discoveries about the mechanisms of action of the lncRNAs ANRIL, H19 and TUG1 and their clinical relevance in these pathologies. This may contribute to early detection of cardiovascular diseases in order to prevent the pathological phenotype from becoming established.

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Funding

This study was supported by National Council for Scientific and Technological Development (CNPq, Grant No. 310905/2020-6, CNPq Research Productivity Scholarship), Universidade Federal de Ouro Preto (Grant No. 17202317) and Minas Gerais State Research Support Foundation (FAPEMIG, Process APQ-03555-22).

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Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Morro do Cruzeiro, s/nº, Ouro Prêto, Minas Gerais, CEP 35402-163, Brazil

    Lívia da Cunha Agostini & Glenda Nicioli da Silva

  2. Escola Superior Instituto Butantan (ESIB), Laboratório de Dor e Sinalização, Instituto Butantan, São Paulo, São Paulo, Brazil

    Tamires Cunha Almeida

  3. Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Prêto, Brazil

    Glenda Nicioli da Silva

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  1. Lívia da Cunha Agostini
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  2. Tamires Cunha Almeida
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  3. Glenda Nicioli da Silva
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Correspondence to Glenda Nicioli da Silva.

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da Cunha Agostini, L., Almeida, T.C. & da Silva, G.N. ANRIL, H19 and TUG1: a review about critical long non-coding RNAs in cardiovascular diseases. Mol Biol Rep 51, 31 (2024). https://doi.org/10.1007/s11033-023-09007-x

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