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The potential role of miR-124-3p in tumorigenesis and other related diseases

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Abstract

MicroRNAs (miRNAs) are a class of single‐stranded noncoding and endogenous RNA molecules with a length of 18–25 nucleotides. Previous work has shown that miR-124-3p leads to malignant progression of cancer including cell apoptosis, migration, invasion, drug resistance, and also recovers neural function, affects adipogenic differentiation, facilitates wound healing through control of various target genes. miR-124-3p has been mainly previously characterized as a tumor suppressor regulating tumorigenesis and progression in several cancers, such as hepatocellular carcinoma (HCC), gastric cancer (GC), bladder cancer, ovarian cancer (OC), and leukemia, as a tumor promotor in breast cancer (BC), and it has been also widely studied in a variety of neurological diseases, like Parkinson’s disease (PD), dementia and Alzheimer’s disease (AD), and cardiovascular diseases, ulcerative colitis (UC), acute respiratory distress syndrome (ARDS). To lay the groundwork for future therapeutic strategies, in this review we mainly focus on the most recent years of literature on the functions of miR-124-3p in related major cancers, as well as its downstream target genes. Although current work as yet provides an incomplete picture, miR-124-3p is still worthy of more attention as a practical and effective clinical biomarker.

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Funding

National Natural Science Foundation of China, Grant/Award Number: 81672737.

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Authors and Affiliations

  1. Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, 9 West Section, Lvshun Southern Road, Dalian, 116044, China

    Qian Li & Ming-Zhong Sun

  2. Department of Biochemistry, College of Basic Medical Sciences, Dalian Medical University, 9 West Section, Lvshun Southern Road, Dalian, 116044, China

    Shuqing Liu

  3. Department of Hematology, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China

    Qian Li, Shuqing Liu, Jinsong Yan & Ming-Zhong Sun

  4. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA, 01610, USA

    Frederick T. Greenaway

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  1. Qian Li
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  4. Ming-Zhong Sun
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All the authors contributed to the preparation of this manuscript. LQ, LSQ and YJS were responsible for the literature search and the first draft of this article. SMZ and FTG were responsible for language polishing and further editing the manuscript. All authors read and approved the final manuscript.

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Correspondence to Shuqing Liu or Ming-Zhong Sun.

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Li, Q., Liu, S., Yan, J. et al. The potential role of miR-124-3p in tumorigenesis and other related diseases. Mol Biol Rep 48, 3579–3591 (2021). https://doi.org/10.1007/s11033-021-06347-4

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