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The romantic history of signaling pathway discovery in cell death: an updated review

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Abstract

Cell death is a fundamental physiological process in all living organisms. Processes such as embryonic development, organ formation, tissue growth, organismal immunity, and drug response are accompanied by cell death. In recent years with the development of electron microscopy as well as biological techniques, especially the discovery of novel death modes such as ferroptosis, cuprotosis, alkaliptosis, oxeiptosis, and disulfidptosis, researchers have been promoted to have a deeper understanding of cell death modes. In this systematic review, we examined the current understanding of modes of cell death, including the recently discovered novel death modes. Our analysis highlights the common and unique pathways of these death modes, as well as their impact on surrounding cells and the organism as a whole. Our aim was to provide a comprehensive overview of the current state of research on cell death, with a focus on identifying gaps in our knowledge and opportunities for future investigation. We also presented a new insight for macroscopic intracellular survival patterns, namely that intracellular molecular homeostasis is central to the balance of different cell death modes, and this viewpoint can be well justified by the signaling crosstalk of different death modes. These concepts can facilitate the future research about cell death in clinical diagnosis, drug development, and therapeutic modalities.

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Author notes

  1. Lei-Yun Wang and Xing-Jian Liu have contributed equally to this work and share first authorship.

Authors and Affiliations

  1. Department of Pharmacy, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, People’s Republic of China

    Lei-Yun Wang, Ying Zhu, Hui-Li Ren & Shao-Hui Zhang

  2. Department of Pharmacy, Wuhan No.1 Hospital, Wuhan, 430022, Hubei, People’s Republic of China

    Lei-Yun Wang, Ying Zhu, Hui-Li Ren & Shao-Hui Zhang

  3. Oujiang Laboratory, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People’s Republic of China

    Xing-Jian Liu & Jia-Nan Song

  4. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, People’s Republic of China

    Qiu-Qi Li

  5. Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of China

    Jun Zeng

  6. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of China

    Jie Mei

  7. Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, 410008, Hunan, People’s Republic of China

    Jie Mei

  8. Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha, 410008, Hunan, People’s Republic of China

    Jie Mei

  9. National Clinical Research Center for Geriatric Disorders, 87 Xiangya Road, Changsha, 410008, Hunan, People’s Republic of China

    Jie Mei

  10. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People’s Republic of China

    Hui-Xiang Tian

  11. Department of Orthopaedic Surgery, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, Guangdong, People’s Republic of China

    Ding-Chao Rong

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S-HZ, D-CR and H-XT designed the review and the structure of this manuscript. L-YW and X-JL wrote the manuscript draft. Q-QL, YZ, H-LR, J-NS, JZ and JM helped to search reference of this review and contributed to the writing. S-HZ contributed to the revision and finalization of the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Hui-Xiang Tian, Ding-Chao Rong or Shao-Hui Zhang.

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Wang, LY., Liu, XJ., Li, QQ. et al. The romantic history of signaling pathway discovery in cell death: an updated review. Mol Cell Biochem (2023). https://doi.org/10.1007/s11010-023-04873-2

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