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Thermally induced interactions between adamantan-2-one and some pharmaceutical excipients

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Abstract

Adamantan-2-one is an adamantane derivative used as a precursor in the synthesis of different pharmacologically active substances, i.e., memantine hydrochloride which was investigated in one of our previous published papers, both as pure compound and in binary mixtures. The aim of our study is to determine the influence of the oxo group regarding the thermal stability of the hydrocarbon structure and also to evaluate possible interactions of the functional groups with various compounds used as excipients. For this purpose, we evaluated the thermal behavior of adamantan-2-one and its compatibility with some excipients used in drug formulations. The pure compounds and the binary mixtures of adamantan-2-one with different excipients were investigated by TG/DTG/HF thermal methods in dynamic air flow, at a heating rate of 10 °C min−1 until 550 °C and by FTIR spectroscopy.

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Acknowledgements

This work was supported by the PN-II-RU-TE-2014-4-0515 to Gabriela Vlase and Adriana Ledeti. Funding was provided by UEFISCDI.

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Authors and Affiliations

  1. Faculty of Chemistry, Biology, Geography, West University of Timisoara, Pestalozzi Street 16, Timisoara, 300115, România

    Gabriela Vlase, Mihaela Budiul, Titus Vlase & Paul Albu

  2. Faculty of Pharmacy, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, Timişoara, 300041, România

    Gabriela Vlase & Adriana Ledeţi

  3. Department of Pharmaceutical Sciences, Faculty of Pharmacy, “Vasile Goldis” Western University of Arad, 86 L. Rebreanu St., Arad, 310414, România

    Paul Albu

Authors
  1. Gabriela Vlase
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  2. Mihaela Budiul
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  3. Titus Vlase
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  4. Paul Albu
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  5. Adriana Ledeţi
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Correspondence to Paul Albu.

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Vlase, G., Budiul, M., Vlase, T. et al. Thermally induced interactions between adamantan-2-one and some pharmaceutical excipients. J Therm Anal Calorim 131, 201–213 (2018). https://doi.org/10.1007/s10973-017-6332-2

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  • DOI: https://doi.org/10.1007/s10973-017-6332-2

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