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Advances in the Study of Liposomes Gel with Stimulus Responsiveness in Disease Treatment

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Abstract

With the extensive applications of nanomaterials in drug delivery in recent years, nanocarriers with composite polymers, represented by liposomal gels, have been studied for drug delivery for numerous diseases. The drug is loaded inside the liposomal gel and is endowed with specific temperature, pH, enzyme, light, electric field and other stimulating materials; further, the release of the loaded drug is controlled by specific stimuli. Liposomal gels provide better stability for drug formulation and obtaining higher targeting and stimulus responsiveness compared to single nano-drug-loaded materials. Hence, the toxic side effects of drugs can be effectively reduced and the drug delivery efficiency, therapeutic efficacy and safety can be considerably improved. At present, research on liposome gels as drug delivery carriers is still under developing stage, and their advantages as drug carriers will be more useful in practice and become a powerful tool for human beings to cure diseases in the future. In the future studies, the synthesis and stimuli-responsive mechanism of liposomal gels can be further explored to expand their applications in the field of disease treatment and provide more innovative solutions for precision medicine and individualised therapy. This review explores the application of liposome gels with stimuli-responsiveness as drug carriers for treating diseases, the advantages of liposome gels as drug carriers, the methods and principles of their fabrication, the stimuli-responsiveness of liposome gels for targeted release against diseases and its current challenges and opportunities to suggest certain methods and ideas for the development of smarter precision-targeted hybrid nanosystems in the future.

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Acknowledgments

The authors are thankful to the editor and reviewers of this manuscript for providing excellent suggestions for the improvement of the manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

This overview was supported by the Young Scientists Fund of the National Natural Science Foundation of China (82104403), Yunnan Province Clinical Medical Research Center for Elderly Diseases (202102AA310069), Yunnan Province Natural Science Foundation Project (202101AT070274), Dong Birong Expert Workstation (202105AF150032)

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Authors and Affiliations

  1. Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Yunnan University of Chinese Medicine, Kunming, 650500, China

    Qiuqiong Yang, Shicui Luo, Sen Tong, Huanhuan Zhao, Bo Song & Junzi Wu

  2. Key Laboratory of Microcosmic Syndrome Differentiation, Yunnan University of Chinese Medicine, Kunming, 650500, China

    Qiuqiong Yang, Shicui Luo, Sen Tong, Huanhuan Zhao, Bo Song & Junzi Wu

  3. Chinese Medicine Orthopedics and Traumatology College, Guizhou University of Traditional Chinese Medicine, Guiyang, 550000, China

    Rang Chen

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BS and JW were corresponding authors who contributed to the study's conception, design, and revision; QY prepared the manuscript and wrote the major part of the manuscript; SL participated in some of the manuscript writing and literature collection; TS was responsible for reviewing the literature and collecting relevant materials; HZ and RC helped to revise the manuscript. All authors approved the final version of this manuscript.

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Yang, Q., Luo, S., Tong, S. et al. Advances in the Study of Liposomes Gel with Stimulus Responsiveness in Disease Treatment. J Clust Sci 35, 701–714 (2024). https://doi.org/10.1007/s10876-023-02510-y

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