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Enhanced cellular osteogenic differentiation on Zn-containing bioglass incorporated TiO2 nanorod films

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

Surface nanotopography and bioactive ions have been considered to play critical roles on the interactions of biomaterials with cells. In this study, a TiO2 nanorod film incorporated with Zn-containing bioactive glass (TiO2/Zn-BG) was prepared on tantalum substrate, trying to evaluate the synergistic effects of nanotopograpgy and bioactive ions to promote cellular osteogenic differentiation activity. The expression of osteogenic-related genes, ALP as well as the ECM mineralization on TiO2/Zn-BG film were significantly upregulated compared to that of the film without TiO2 nanorod nanostructure (Zn-BG) or without Zn (TiO2/BG). Moreover, a much low Zn2+ release level on TiO2/Zn-BG film was beneficial to promote the osteogenesis, which could be ascribed to that a semi-closed space established by TiO2 nanorods with adhered cells provided an appropriate micro-environment that facilitated Zn2+ adsorption.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (51472216, 51772273, 51502262), the 111 Project under Grant No. B16042, and the Postdoctoral Science Foundation of China (Grant No. 2017M621923).

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Author notes

  1. These authors contributed equally: Meng He, Xiaoyi Chen.

Authors and Affiliations

  1. School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, 310027, China

    Meng He, Kui Cheng & Wenjian Weng

  2. The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China

    Xiaoyi Chen, Lingqing Dong & Huiming Wang

Authors
  1. Meng He
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  2. Xiaoyi Chen
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  3. Kui Cheng
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  5. Wenjian Weng
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Correspondence to Wenjian Weng or Huiming Wang.

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He, M., Chen, X., Cheng, K. et al. Enhanced cellular osteogenic differentiation on Zn-containing bioglass incorporated TiO2 nanorod films. J Mater Sci: Mater Med 29, 136 (2018). https://doi.org/10.1007/s10856-018-6141-6

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