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Flexible nano-piezoelectric membranes with spontaneous electric field generation for bacteria elimination and wound healing

  • Materials for life sciences
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Abstract

Electrical stimulation therapy has attracted widespread attention for its advantages of promoting cell proliferation and tissue regeneration, accelerating skin barrier restoration, and reducing scars. Its effect on accelerating wound healing has been clinically proven. However, traditional electrical stimulation therapy requires large power supply devices, which are inconvenient to carry and use. Therefore, self-powered flexible nano-piezoelectric membranes were developed in this work, which can generate electric field under mechanical stimulation to effectively eliminate bacteria and accelerate wound healing. In this work, poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) piezoelectric membranes were fabricated by electrospinning, and better piezoelectric properties were obtained by adding tetrabutylammonium chloride (TBAC), and their antibacterial and pro-healing effects were investigated with or without mechanical stimulation. Results showed that the output voltage of P(VDF-TrFE)/TBAC piezoelectric membrane was about 5.3 times higher than that of P(VDF-TrFE). Furthermore, the P(VDF-TrFE)/TBAC piezoelectric membrane had excellent antibacterial effect against both Escherichia coli and Staphylococcus aureus after mechanical stimulation, and the inhibition rates of Staphylococcus aureus and Escherichia coli were 71.43% and 97.25%, respectively. Meanwhile, the results of in vivo and in vitro healing promotion experiments showed that P(VDF-TrFE)/TBAC piezoelectric membrane was effective in promoting cell growth and wound healing after mechanical stimulation, the wound was almost completely healed on the 7th day, and the healing rate was increased by about 37% compared with the blank. The P(VDF-TrFE)/TBAC flexible piezoelectric membrane is effective in electrical stimulation for wound healing, and it has potential applications in wound treatment.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (No.32101081), the Natural Science Foundation of Sichuan Province (2022NSFSC0379). We would be grateful to Doctor Mingxia Sun (Analytical and Testing Center, Sichuan University) for her help of taking laser scanning confocal images.

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Authors and Affiliations

  1. Key Laboratory of Leather Chemistry and Engineering of the Education Ministry, Sichuan University, Chengdu, 610065, Sichuan, China

    Na Yang, Yining Chen, Nianhua Dan, Xin Zheng, Rongxin Feng, Guofei Yu, Xiaotang He & Weihua Dan

  2. Research Center of Biomedical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China

    Yining Chen, Nianhua Dan & Weihua Dan

  3. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610065, Sichuan, China

    Yunbing Wang

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  1. Na Yang
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Contributions

NY performed conceptualization, methodology, validation, investigation, writing-original draft, visualization. YC has given technical guidance for fabrication, writing-review and editing, funding acquisition. ND did writing-review and editing, resources, funding acquisition. XZ done methodology, formal analysis, supervision. RF: software, validation. GY was involved in formal analysis. XH done software. WD and YW contributed to conceptualization.

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Correspondence to Nianhua Dan.

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Yang, N., Chen, Y., Dan, N. et al. Flexible nano-piezoelectric membranes with spontaneous electric field generation for bacteria elimination and wound healing. J Mater Sci 57, 19532–19552 (2022). https://doi.org/10.1007/s10853-022-07871-9

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