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Impaired P1 Habituation and Mismatch Negativity in Children with Autism Spectrum Disorder

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Abstract

Passive testing of auditory function is an important objective in individuals with ASD due to known difficulties in understanding and/or following task instructions. In present study the habituation to standard tones following deviants and the auditory discriminative processes were examined in two conditions: electronic and human sounds, in a sample of 16 ASD children. ASD children presented a reduced habituation in the P1 component and a decrease in the amplitude of the mismatch negativity indicating a lower auditory discrimination with respect to controls. MMN amplitude was related to sensory sensitivity. Results suggest an increased activation to repeatedly auditory stimulus and a poor auditory discrimination, for both: electronic and human sounds with consequences on the impaired sensory behavior of ASD subjects.

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Funding

This work has been possible thanks to Grants from the Ministry of Science (PSI2016-80059-R; FEDER funds). CEW was supported by the Talentia Postdoc Program launched by the Andalusian Knowledge Agency, co-funded by the European Union’s Seventh Framework Program, Marie Skłodowska-Curie actions (COFUND—Grant Agreement No. 267226) and the Ministry of Economy, Innovation, Science and Employment of the Junta de Andalucía.

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Authors and Affiliations

  1. Human Psychobiology Lab, Department of Experimental, Psychology, Universidad de Sevilla, Calle Camilo José Cela, s/n, 41018, Seville, Spain

    Francisco J. Ruiz-Martínez, Elena I. Rodríguez-Martínez & Carlos M. Gómez

  2. Individual Differences, Language and Cognition Lab, Department of Developmental and Educational Psychology, Universidad de Sevilla, Seville, Spain

    C. Ellie Wilson & David Saldaña

  3. School of Psychology and Exercise Science, Murdoch University, Perth, Australia

    Shu Yau

  4. School of Education, University of Bristol, Bristol, UK

    Shu Yau

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  1. Francisco J. Ruiz-Martínez
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Contributions

FJR contributes experimental programming, subject recruitment, EEG recording, data analysis, article writing. EIR contributes neuropsychological tests and EEG recording. CEW contributes experimental designs, subject recruitment and text editing. SY contributes experimental design and stimuli design. DS contributes experimental design. CMG experimental design, article writing and supervision.

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Correspondence to Francisco J. Ruiz-Martínez.

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Informed consent was obtained from all individual participants included in the study.

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Ruiz-Martínez, F.J., Rodríguez-Martínez, E.I., Wilson, C.E. et al. Impaired P1 Habituation and Mismatch Negativity in Children with Autism Spectrum Disorder. J Autism Dev Disord 50, 603–616 (2020). https://doi.org/10.1007/s10803-019-04299-0

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