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Is the clinical course of non-arteritic ischemic optic neuropathy associated with oxidative damage and the dynamics of the antioxidant response?

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Abstract

Purpose

Oxidative stress is known to be a decisive factor in the wide etiopathogenesis of optic neuropathy. This study aimed to comprehensively evaluate the interaction of optic neuropathy’s clinical course with systemic oxidative damage and antioxidant response dynamics in a large series.

Methods

This case-controlled clinical study included 33 non-arteritic anterior ischemic optic neuropathy (NAION) patients and 32 healthy individuals. Extensive systemic oxidation profiles were statistically compared between the two groups, and correlations between the clinical and biochemical data in the study group were analyzed.

Results

Vitamin E and malondialdehyde (MDA) levels were significantly higher in the study group. Significant correlations were observed in the analyses between clinical findings and oxidative stress parameters. Correlations between vitamin E and intraocular pressure (IOP), between B12 and cup-to-disk ratio (c/d), between antioxidant glutathione and superoxide dismutase (SOD) enzyme systems, and between uric acid (UA) and age were found to be very significant. As significant correlations were found in either clinical and biochemical data or in oxidative stress parameters, correlations between vitamin E and cholesterol, MDA were found to be very significant.

Conclusions

This study not only supplies significant information regarding oxidative damage and antioxidant response in NAION, but also points out the specific interactions of neuromodulators, like vitamin E, in intracellular signaling pathways and regulation mechanisms. A better reading of these connections may help improve diagnosis, follow-ups and treatment criteria and strategies.

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Acknowledgements

The authors thank all the participants who collaborated in this research with enthusiasm.

Funding

The study was sponsored by BAP-Izmir Dokuz Eylül University Research Fund (2016.KB.SAG.062).

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Authors and Affiliations

  1. Department of Ophthalmology, Ümraniyemraniye Education and Research Hospital, Sağlık University, Elmalıkent Mh. Ümraniye, 34764, Istanbul, Turkey

    Kaya Nusret Engin

  2. Graduate School of Health Science, Department of Molecular Genetics, Dokuz Eylül University, Izmir, Turkey

    Duygu Harmancı Karagülle & Hüray İşlekel

  3. Faculty of Medicine, Department of Ophthalmology, Dokuz Eylül University, Izmir, Turkey

    Ceren Durmaz Engin, Aylin Yaman & Meltem Söylev Bajin

  4. Faculty of Medicine, Department of Biochemistry, Dokuz Eylül University, Izmir, Turkey

    Melis Kant, Merve Akış & Hüray İşlekel

  5. Istanbul Faculty of Medicine, Department of Biostatistics, Istanbul University, Istanbul, Turkey

    Sevda Özel Yıldız

  6. Department of Medical Biochemistry, School of Medicine, Izmir University of Economics, Izmir, Turkey

    Gül Güner Akdoğan

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  1. Kaya Nusret Engin
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Contributions

EKN constructed the hypothesis and wrote the project, contributed to material preparation, data collection, and wrote the manuscript. The project was produced and conducted by EKN, as S-BM, GG, İH, YA contributed to development of the ideas, design and supervision of the course of the project. D-EC and H-KD collected data, and all the authors except Y-ÖS contributed to material preparation and data analysis. Y-ÖS performed the statistical analysis. All authors have read and approved the final version of the manuscript.

Corresponding author

Correspondence to Kaya Nusret Engin.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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The research adhered to the tenets of the Declaration of Helsinki. Approval from the Ethics Committee of Dokuz Eylül University, as well as informed consent from the subjects, was obtained.

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Engin, K.N., Harmancı Karagülle, D., Durmaz Engin, C. et al. Is the clinical course of non-arteritic ischemic optic neuropathy associated with oxidative damage and the dynamics of the antioxidant response?. Int Ophthalmol 43, 2935–2945 (2023). https://doi.org/10.1007/s10792-023-02699-x

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