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Gastrointestinal signet ring cell malignancy: current advancement and future prospects

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Abstract

Globally, gastrointestinal cancer is the most widespread neoplastic disease and the primary contributor to cancer-associated fatalities. Gastrointestinal signet ring cell carcinoma (SRCC) exhibits unique distinguishing features in several aspects when compared to adenocarcinomas (ACs). The scarcity of signet ring cell carcinoma has resulted in a heightened significance of related clinical and molecular investigations. However, a comprehensive and systematic review of the clinical, molecular, therapeutic, and research aspects of this disease is currently absent. This review provides an overview of the latest developments in our understanding of the clinical and molecular features of gastrointestinal signet ring cell carcinoma (SRCC). Additionally, we have compiled a list of potential therapeutic targets or biomarkers, as well as an examination of the current treatment options and the possible mechanisms of formation.

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Data Availability

All data generated or analysed during this study are included in this published article.

Abbreviations

SRCC:

Signet ring cell adenocarcinomas

CMT:

Combined modality therapy

GC:

Gastric cancer

CRC:

Colorectal cancer

AC:

Conventional adenocarcinoma

MAC:

Mucinous adenocarcinoma

G-SRCC:

Gastric SRC carcinoma

IGCA:

International Gastric Cancer Association

PC:

Poorly cohesive

WMD:

Well-to-moderately differentiated

NSRCC:

Non-SRC

CRC:

Colorectal cancer

CR-SRCC:

Signet ring cell colorectal cancer

ctDNA:

Circular tumour DNA

MRD:

Molecular residual disease

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Acknowledgements

We thank Dr. Wanglong Deng, Dr. Guanghua Lu, Mr. Ran Ding from Jiangsu Simcere Diagnostics for their kind assistance.

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Authors and Affiliations

  1. Department of Oncology, Guangdong Sanjiu Brain Hospital, 578 Shatai Road, Baiyun District, Guangzhou City, Guangdong Province, China

    Weiping Hong & Qingjun Hu

  2. The Medical Department, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing Simcere Medical Laboratory Science Co., Ltd., The State Key Lab of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing, China

    Yuan Tan, Qianqian Duan, Qin Zhang, Dongsheng Chen & Chuang Qi

  3. Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Rd., Hangzhou, China

    Da Wang

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Contributions

Author ContributionsConception/design: D.W, WP.H; Provision of study material or patients: QJ.H, Y.T, QQ. D, Q.Z; Collection and/or assembly of data: C.Q, DS.C Data analysis and interpretation: All authors. Manuscript writing: D.W, WP.H Final approval of manuscript: All authors.

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Hong, W., Hu, Q., Tan, Y. et al. Gastrointestinal signet ring cell malignancy: current advancement and future prospects. Invest New Drugs 41, 861–869 (2023). https://doi.org/10.1007/s10637-023-01403-1

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