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Two New Anti-Tobacco Mosaic Virus Isoindolin-1-Ones from the Leaves of Nicotiana tabacum

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Chemistry of Natural Compounds Aims and scope

Two new isoindolin-1-ones, 6-(3-hydroxypropyl)-2,4-dimethylisoindolin-1-one (1) and 4-(hydroxymethyl)-6-(3-hydroxypropyl)-2-methylisoindolin-1-one (2), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1 and 2 exhibited high anti-TMV activities with inhibition rates of 42.3 and 46.2% at the concentration of 20 μM, respectively.

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Acknowledgment

This work was supported financially by the Foundation of Yunnan Basic Research Program (2019FD086), the National

Natural Science Foundation of China (No. 21967021), the Foundation of Yunnan Tobacco Industry Co., Ltd. (2018JC07),

and the high-tech Projects of Yunnan Province (2017ZE027).

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Authors and Affiliations

  1. Technology Center, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Li Xu, Tao Zhou, Jian-Duo Zhang, Le-Le Deng, Jia-Rui Jiang, Wen-Wu Yang, Chun-Bo Liu, Wei-Song Kong, Xue-Mei Li, Guang-Yu Yang & Xin Liu

  2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Li Xu & Qiu-Fen Hu

Authors
  1. Li Xu
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  2. Tao Zhou
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  4. Le-Le Deng
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  5. Jia-Rui Jiang
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  9. Xue-Mei Li
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  10. Guang-Yu Yang
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  11. Qiu-Fen Hu
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  12. Xin Liu
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Corresponding authors

Correspondence to Qiu-Fen Hu or Xin Liu.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2021, pp. 898–900.

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Xu, L., Zhou, T., Zhang, JD. et al. Two New Anti-Tobacco Mosaic Virus Isoindolin-1-Ones from the Leaves of Nicotiana tabacum. Chem Nat Compd 57, 1047–1050 (2021). https://doi.org/10.1007/s10600-021-03547-z

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  • DOI: https://doi.org/10.1007/s10600-021-03547-z

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